Prevalence of hand disorders in type 2 diabetes mellitus and its correlation with microvascular complications

Abstract

Background:Physicians have long recognized the association between diabetes mellitus and several pathologic conditions of the hand. The most commonly recognized maladies are limited joint mobility (LJM), Dupuytren's disease (DD), trigger finger (TF), and carpal tunnel syndrome (CTS). Incidence of these hand disorders has increased in the setting of diabetes. Collectively, these are described as diabetic hand syndrome.Aim:The aims were to find out the prevalence of hand disorders in diabetic patients, and to study the relation of these hand disorders with microvascular complications.Subjects and Methods:This is an observational cross-sectional case-control study done over a period of 1 year Patients of type 2 DM, of age < 65 years, who visited Gandhi Memorial Hospital, Lucknow were enrolled and were described as cases. Age- and sex-matched nondiabetic individuals were taken in the control group. The data were analyzed using software SPSS. SPSS Inc. Released 2008. SPSS Statistics for Windows, Version 17.0. Chicago: SPSS Inc. Means and standard deviations were computed; the Student t-test and Chi-square (χ2) test were used as appropriate.Results:A total of 400 subjects were studied, 200 each in the case and control groups. Of total 200 diabetic patients, 30% (60/200) patients had neuropathy, 37.5% (75/200) had nephropathy, and 44.5% (89/200) patients had retinopathy. In the study population, 67% patients were having one or more hand disorders, in which LJM was found in 40.5% (81/200) patients, DD was found in 19% (38/200) patients, TF in 16.5% (33/200), and CTS in 14% (28/200) patients.Conclusions:This study shows a high prevalence of hand disorders in diabetic patients and also correlates with the duration of type 2 DM, LJM being the most common hand disorder and more common in patients who have microvascular complications.

Risk of Hand Syndromes in Patients With Diabetes Mellitus

“…Patients with DM may experience certain musculoskeletal complications because of macrovascular and microvascular complications. 18 , 19 An increase of advanced glycosylation end-products (AGEs) may result in skin thickening and formation of nodules and contractures. 20 , 21 In addition, unregulated proliferation of collagen may also result from irregular expression of peptides that regulated a number of growth factors including cytokines transforming growth factor-β 22 and basic fibroblast growth factor.…”

Musculoskeletal problems in diabetes mellitus

“…Other risk factors include past myocardial infarction, retinopathy, and peripheral neuropathy. FS is also associated with other hand problems such as DC and cheiroarthropathy ( 8 ). Imaging, histological, and histochemical studies have revealed the presence of fibroblasts with heavy proliferation in the tissue due to cytokine-mediated inflammation, T-cells, macrophages, and chronic inflammatory infiltration comprising mast cells, and accompanying Type I and Type III collagen accumulation.…”

Pengaruh Rubber Ball Training Terhadap Peningkatan Kekuatan Menggenggam Pada Lansia Diabetes Mellitus Di Persadia Cipayung

“…Seperti jari Trigger Finger, kontraktur Dupuytren, dan lesi kompresi saraf perifer. Keterbatasan mobilitas sendi juga dikenal sebagai diabetes cheiroarthropathy / sindrom tangan kaku diabetik dan telah ditemukan pada 8-50% dari semua pasien dengan diabetes tipe 1 dan juga terlihat pada pasien diabetes tipe 2 (Gutch et al, 2013).…”