“…Husam Oudah ALjwaid; Lecturer, Department of Medical Laboratory Technique, College of Medical Technology, National University of Science and Technology, Thi-Qar, Iraq; haljwad@yahoo.com abscesses or thrombosis (2,5,6) .The bacterial cause for CSOM can include both aerobic and anaerobic bacteria ,the most common microorganisms found in CSOM are P. aeruginosa, Staphylococcus aureus, Proteus mirabilis, Klebseilla pneumonia ,diphtheroid group, Citrobacter sp., etc and anaerobic bacteria (5,7,8 ) and fungi like Candida sp as well asAspergillus sp. (8,9) P. aeruginosa is one of the most predominant organisms to cause CSOM (10,11), with an incidence ranging from 21% to 52.94% (12) .…”
Background: Chronic Suppurative otitis media (CSOM),is a chronic inflammation of the middle ear and mastoid cavity, which presents with recurrent (otorrhea) ear discharge through a perforated tympanic membrane. The bacterial cause for CSOM can include both aerobic and anaerobic bacteria ,the most common microorganisms found in CSOM are Pseudomonas aeruginosa, Staphylococcus aureus, Proteus mirabilis, Klebseilla pneumonia , diphtheroid group, Citrobacter sp. and anaerobic bacteria and fungi like Candida sp as well asAspergillus sp. P. aeruginosa was the most common iso 30500000) fallowed by S.aurease 27% (27 isolates) , Proteus mirabilis 11% (11 isolates),E.Coli 11%(11 isolates), Klebseilla pneumonia 9 %(9 isolates), respectively while other different species was 5% (5 isolates) and 2% (2 isolates) was fungi. Antimicrobial sensitivity for P. aeruginosa test by VITEK 2 System based on the main inhibitor concentration (MIC).The Piperacillin showed to be highly sensitive again P. aeruginosa 77.1% (27 isolation ) followed by Meropenem , Imipenem ,Levofloxacin and Amikacin 65.7% (23 isolation), 60%(21 isolation), 40%(14 isolation), 34.2%(12 isolation) respectively while Ciprofloxacin showed to be the les effected again P. aeruginosa 20% (7 isolation). Ceftazidime , Tobramycin and Ciprofloxacin were highly resistance 68.5% (24isolation). 62.8% (22 isolation) . 54.2%(19 isolation) respectively.
“…Husam Oudah ALjwaid; Lecturer, Department of Medical Laboratory Technique, College of Medical Technology, National University of Science and Technology, Thi-Qar, Iraq; haljwad@yahoo.com abscesses or thrombosis (2,5,6) .The bacterial cause for CSOM can include both aerobic and anaerobic bacteria ,the most common microorganisms found in CSOM are P. aeruginosa, Staphylococcus aureus, Proteus mirabilis, Klebseilla pneumonia ,diphtheroid group, Citrobacter sp., etc and anaerobic bacteria (5,7,8 ) and fungi like Candida sp as well asAspergillus sp. (8,9) P. aeruginosa is one of the most predominant organisms to cause CSOM (10,11), with an incidence ranging from 21% to 52.94% (12) .…”
Background: Chronic Suppurative otitis media (CSOM),is a chronic inflammation of the middle ear and mastoid cavity, which presents with recurrent (otorrhea) ear discharge through a perforated tympanic membrane. The bacterial cause for CSOM can include both aerobic and anaerobic bacteria ,the most common microorganisms found in CSOM are Pseudomonas aeruginosa, Staphylococcus aureus, Proteus mirabilis, Klebseilla pneumonia , diphtheroid group, Citrobacter sp. and anaerobic bacteria and fungi like Candida sp as well asAspergillus sp. P. aeruginosa was the most common iso 30500000) fallowed by S.aurease 27% (27 isolates) , Proteus mirabilis 11% (11 isolates),E.Coli 11%(11 isolates), Klebseilla pneumonia 9 %(9 isolates), respectively while other different species was 5% (5 isolates) and 2% (2 isolates) was fungi. Antimicrobial sensitivity for P. aeruginosa test by VITEK 2 System based on the main inhibitor concentration (MIC).The Piperacillin showed to be highly sensitive again P. aeruginosa 77.1% (27 isolation ) followed by Meropenem , Imipenem ,Levofloxacin and Amikacin 65.7% (23 isolation), 60%(21 isolation), 40%(14 isolation), 34.2%(12 isolation) respectively while Ciprofloxacin showed to be the les effected again P. aeruginosa 20% (7 isolation). Ceftazidime , Tobramycin and Ciprofloxacin were highly resistance 68.5% (24isolation). 62.8% (22 isolation) . 54.2%(19 isolation) respectively.
“…Staphylococcus aureus is found everywhere and highly adaptive pathogen that colonizes and infect the epidermis and the mucous membrane of anterior nares, digestive system, the perineum, the genitourinary tracts and the mouth and pharynx [15], and considered as one of the multidrug resistant pathogens. [16][17][18][19][20].…”
The aim of current experiment is estimate the potential effects of D. viscosa extract to treat the kidney tissue changes of infected rats with S. aureus. 30 clinical samples were obtained from patients with chronic lung disease attending Al Jumhuri Hospital, at period February-April 2021. 20 adult rats were utilized in current experiment, and the rats were obtained from Science College house / Mosul University. The current findings demonstrated that the sections of infected rat with S. aureus show damage glomerulus, necrosis of tubules cells and infiltration of mono-nucleated inflammatory cells and thickening wall of renal vessels. After using leaves extract of D. viscosa, the microscopic examination show improved in histological structure of kidney. Whereas, the glomerulus back to semi normal state, provide in of tubules cells and the infiltration of mono-nucleated inflammatory cells was absent. So, the leaves extract of D. viscosa exhibit antibacterial activity and improvement the rat kidney structure after infected with S. aureus.
“…A lot of work has been done to understand the structure and the action mechanism of these enzymes in order to elucidate the acquired immunity of microbes against different drugs [3]. β-Lactamase enzymes are produced from bacteria such as cephamycins, penicillins, cephalosporins, and carbapenems [4,5]. Its action mechanism works by breaking down the beta-lactam ring present in all broad-spectrum antibiotics through hydrolysis, thus deactivating the antibacterial nature of the drug.…”
Section: Introductionmentioning
confidence: 99%
“…Its action mechanism works by breaking down the beta-lactam ring present in all broad-spectrum antibiotics through hydrolysis, thus deactivating the antibacterial nature of the drug. ese antibiotics are used to treat a vast spectrum of Gram-negative and Gram-positive bacterial infections though β-lactamases are produced only from Gram-negative and anaerobic bacteria [5].…”
Beta-lactamase (β-lactamase) produced by different bacteria confers resistance against β-lactam-containing drugs. The gene encoding β-lactamase is plasmid-borne and can easily be transferred from one bacterium to another during conjugation. By such transformations, the recipient also acquires resistance against the drugs of the β-lactam family. β-Lactam antibiotics play a vital significance in clinical treatment of disastrous diseases like soft tissue infections, gonorrhoea, skin infections, urinary tract infections, and bronchitis. Herein, we report a prediction classifier named as βLact-Pred for the identification of β-lactamase proteins. The computational model uses the primary amino acid sequence structure as its input. Various metrics are derived from the primary structure to form a feature vector. Experimentally determined data of positive and negative beta-lactamases are collected and transformed into feature vectors. An operating algorithm based on the artificial neural network is used by integrating the position relative features and sequence statistical moments in PseAAC for training the neural networks. The results for the proposed computational model were validated by employing numerous types of approach, i.e., self-consistency testing, jackknife testing, cross-validation, and independent testing. The overall accuracy of the predictor for self-consistency, jackknife testing, cross-validation, and independent testing presents 99.76%, 96.07%, 94.20%, and 91.65%, respectively, for the proposed model. Stupendous experimental results demonstrated that the proposed predictor “βLact-Pred” has surpassed results from the existing methods.
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