Prevalence of gastroesophageal reflux disorder in arrhythmic patients and adjunctive effects of proton pump inhibitors on comorbid atrial fibrillation

Odashiro, Keita; Yasuda, Shin; Yamaguchi, Taku; Yoda, Shunsuke; Noda, Hironobu; Fukata, Mitsuhiro; Arita, Tomohiro; Maruyama, Toru; Akashi, Koichi

doi:10.18203/2319-2003.ijbcp20150365

Cited by 4 publications

(4 citation statements)

References 20 publications

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“…Всем пациентам инициирована терапия ИПП в течении 6 месяцев. По результатам исследования общие симптомы ГЭРБ (р<0,001), рефлюкс (р<0,001) и регургитация (р=0,013) были значительно снижены на фоне ИПП, также уменьшилась субъективная частота и продолжительность (р=0,001), тяжесть (р<0,001) симптомов ФП, однако анализ данных не подтвердил значительных изменений, касающихся количества (р=0,138) и максимальной продолжительности (р=0,345) пароксизмов ФП [41].…”

Section: влияние медикаментозной терапии гэрб на фпunclassified

Gastroesophageal reflux disease and atrial fibrillation: comorbidity or overlap syndrome? View of gastroenterologist

Белоусова

Чижова

Бакулин

et al. 2020

jour

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Аtrial fibrillation (AF) still occupies a special place in the structure of cardiovascular diseases, both due to its high prevalence, close association with socially significant diseases, and due to the high risks of death, stroke, and other thromboembolic complications. In turn, a patient with AF is always a comorbid patient, and among extracardiac pathology, the prevalence of diseases of the upper gastrointestinal tract, especially gastroesophageal reflux disease (GERD), pay attention. Recently more and more data have appeared that indicate the non-randomness of this combination. Many authors consider GERD as another independent risk factor for AF, while others propose to consider AF as an extra-esophageal manifestation of GERD, of course, in the absence of other cardiac risk factors. This review discusses the main pathophysiological mechanisms that determine the pathogenetic relationship of AF and GERD, known to date.

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Section: влияние медикаментозной терапии гэрб на фпunclassified

Gastroesophageal reflux disease and atrial fibrillation: comorbidity or overlap syndrome? View of gastroenterologist

Белоусова

Чижова

Бакулин

et al. 2020

jour

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“…Однако не во всех исследованиях четко доказан положительный эффект ИПП при сочетании ГЭРБ и ФП [36,37] (табл. 1), высказываются предположения по поводу потенциального проаритмического эффекта ИПП [38].…”

Section: подходы к лечению пациентов с гэрб и фпunclassified

Atrial fibrillation and gastrooesophageal reflux disease: association mechanisms, treatment approaches

2019

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ГЭРБ-гастроэзофагеальная рефлюксная болезнь, ЖКТ-желудочно-кишечный тракт, ИПП-ингибиторы протонной помпы, ЛП-левое предсердие, РЧАрадиочастотная аблация, ФП-фибриллация предсердий, ЭКГ-электрокардио грамма, RELY-Randomized Evaluation of Long-term anticoagulant therpY.

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“…Many paroxysms of AF are usually asymptomatic, and hence accurate diagnosis of AF should be based on the insertable loop recorder or the implantable device interrogation . In this sense, Odashiro et al investigated the prevalence of GERD in arrhythmic patients and the effects of adjunctive PPI administration on the comorbid AF. They showed (a) that AF was most prevalent in arrhythmic patients associated with GERD and (b) that temporal correlation between AF and GERD symptoms was improved simultaneously by the oral administration of PPI.…”

Section: Strength and Limitationsmentioning

confidence: 99%

“…Because susceptible age for AF overlaps that for GERD, causal relationship between AF and GERD has been suggested. Since we encountered a case of paroxysmal AF treated successfully by proton pump inhibitor (PPI) administered for coexisting GERD, the relationship between AF and GERD has been investigated in our laboratory . In this article, we review the potential linkage of these two common diseases including our investigations and highlight that this association is not coincidental, i.e., the two common diseases show natural linkage and the treatments of AF affects GERD and vice versa irrespective of whether the treatment is pharmacological or non‐pharmacological.…”

Section: Introductionmentioning

confidence: 99%

Association of atrial fibrillation and gastroesophageal reflux disease: Natural and therapeutic linkage of the two common diseases

Maruyama

Fukata

Akashi

2018

Journal of Arrhythmia

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Atrial fibrillation (AF) is a common arrhythmia and gastroesophageal reflux disease (GERD) is popular in Japan. The two common diseases share several predisposing factors such as lifestyle and senescence, and inflammation and oxidative stress play an important role in their development and progression. Incidental cases of AF treated successfully by proton pump inhibitor (PPI) applied for coexisting GERD have been sporadically reported. An increasing evidence indicates that GERD induces the initiation and the perpetuation of AF. This is caused by the autonomic nerve influence, mechanical compression, and propagation of local inflammation due to proximity of left atrium (LA) and lower esophagus. Meanwhile, AF also develops GERD by mechanical and inflammatory actions of LA characterized by remodeling and inflammation. The robust association of AF with GERD is not limited to their natural interaction, i.e., pharmacological or nonpharmacological treatment of AF is reported to aggravate GERD. Many cardiac drugs (anticoagulants, calcium antagonists, and nitrates) induce esophageal mucosal damage and lower esophageal sphincter relaxation promoting acid reflux. These drugs are frequently prescribed in patients with AF for stroke prevention, rate control, and for coexisting coronary heart disease. Catheter ablation also yields both GERD and esophageal thermal injury, which is a precursor lesion of atrioesophageal fistula. The notion that AF and GERD are mutually interdependent is widely and empirically recognized. However, mechanistic link of the two common diseases and objective evaluation of PPI as an adjunctive AF treatment warrant future large‐scale prospective trials.

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Prevalence of gastroesophageal reflux disorder in arrhythmic patients and adjunctive effects of proton pump inhibitors on comorbid atrial fibrillation

Cited by 4 publications

References 20 publications

Gastroesophageal reflux disease and atrial fibrillation: comorbidity or overlap syndrome? View of gastroenterologist

Gastroesophageal reflux disease and atrial fibrillation: comorbidity or overlap syndrome? View of gastroenterologist

Atrial fibrillation and gastrooesophageal reflux disease: association mechanisms, treatment approaches

Association of atrial fibrillation and gastroesophageal reflux disease: Natural and therapeutic linkage of the two common diseases

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