Prevalence of Gastric Preneoplastic Lesions in First-Degree Relatives of Patients with Gastric Cancer: a Cross-Sectional Study

Sotelo, Sergio; Manterola, Carlos; Otzen, Támara; Morales, Erik; Castillo, Iván

doi:10.1007/s12029-022-00827-x

Cited by 3 publications

(3 citation statements)

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“…All the studies included in this systematic review indicated that a first‐degree family history of gastric cancer represents a risk factor for gastric cancer 14–43 . The studies included in our systematic review provided interesting insights through subanalyses that explored various factors, such as gender, the type of family member affected (father, mother, or sibling), the specific anatomical site of cancer (corpus/antrum), geographical risk, and age considerations.…”

Section: Resultsmentioning

confidence: 95%

“…In one study, the risk of gastric cancer in family history was higher in the intestinal histotype 16 ; conversely, in another study, greater familial risk was documented in the diffuse histotype 24 . H. pylori infection was closely associated with a higher incidence of patients having first‐degree relatives with gastric cancer compared to the general population 22,32,39 . Focusing on the specific anatomical site affected within the stomach, a study revealed an increased prevalence of antrum gastric cancer in these patients 31 ; in contrast, another study documented a higher risk in the corpus 15 .…”

Section: Resultsmentioning

confidence: 99%

“…24 H. pylori infection was closely associated with a higher incidence of patients having first-degree relatives with gastric cancer compared to the general population. 22,32,39 Focusing on the specific anatomical site affected within the stomach, a study revealed an increased prevalence of antrum gastric cancer in these patients 31 ; in contrast, a Newcastle-Ottawa Quality Assessment Scale (adapted for cross-sectional studies).…”

Section: Gastric Cancermentioning

confidence: 99%

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Systematic review and meta‐analysis: Risk of gastric cancer in patients with first‐degree relatives with gastric cancer

Ligato,

Dottori,

Sbarigia

et al. 2024

Aliment Pharmacol Ther

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SummaryBackgroundGastric cancer ranks fourth in terms of global cancer‐related deaths. Timely identification of high‐risk populations is crucial to reduce mortality. Although a family history of gastric cancer increases risk, European and British guidelines report weak recommendations and low‐quality evidence about the management of these patients.AimTo quantify the association in case–control studies of patients with gastric cancer with first‐degree relatives with gastric cancer compared to those who do not.MethodsWe conducted a systematic review and meta‐analysis of case–control studies up to November 2023. Data extraction was performed independently by two reviewers. The heterogeneity of effects across studies was quantified by I2. We calculated odds ratios (OR) with 95% confidence intervals (CI) using random effects models.ResultsWe included 30 studies in the systematic review. In all studies, a first‐degree family history of gastric cancer represented a risk factor for gastric cancer. We included 21 studies on the risk of gastric cancer. There was a significantly increased association between gastric cancer and having first‐degree relative(s) with gastric cancer, but with significant heterogeneity among studies (OR = 2.92; 95% CI 2.402–3.552; p < 0.001; I2 = 81.85%; p < 0.001).ConclusionThis meta‐analysis highlights the relevance of patients' family history of gastric cancer and the importance of this risk factor for the early detection of neoplastic conditions.

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Section: Resultsmentioning

confidence: 95%