Chemopreventive role of probiotics against cancer: a comprehensive mechanistic review

Noor, Shehzeen; Ali, Shaukat; Riaz, Shumaila; Sardar, Iqra; Farooq, Muhammad; Sajjad, Ayesha

doi:10.1007/s11033-022-08023-7

Cited by 7 publications

(3 citation statements)

References 118 publications

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“…The effective mechanisms of probiotics in eliciting anticancer profiles and bioactive peptides require intricate research. A recent review has demonstrted the chemopreventive role of probiotics in cancer prevention and immunomodulation (Noor et al., 2023). Thus, studies on carcinogenesis and cancer mechanisms, specifying the clinical applications, need extensive studies.…”

Section: Probiotics Derived Secondary Metabolites With Immune‐enhanci...mentioning

confidence: 99%

“…Similar studies have proved that L. acidophilus positively affects colorectal cancer Caco‐2 cell lines, suggesting survival longevity (Isazadeh et al., 2020). Recent research in the mechanisms for probiotics mediating antiproliferation, pro‐apoptotic, and antioxidant potentials has been amply reported (Baghbani‐Arani et al., 2020; Holkem et al., 2021; Noor et al., 2023; Nowak et al., 2022; Rosa et al., 2020). Nevertheless, laboratory results and correlating clinical outcomes require much research.…”

Section: Effects Of Probiotics On Carcinogenesis Apoptosis and Antipr...mentioning

confidence: 99%

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Feasible mechanisms and therapeutic potential of food probiotics to mitigate diabetes‐associated cancers: A comprehensive review and in silico validation

Vinothkanna,

Shi‐Liang,

Karthick Rajan

et al. 2024

Food Frontiers

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People with diabetes mellitus (DM) and hyperglycemia are linked with cancer risk. Diabetes and cancer have been corroborated by high morbidity and mortality rates. Studies revealed that elevated levels of insulin secretions trigger insulin‐like growth factor 1 (IGF‐1) production. Moreover, IGF‐1 is a key regulator involved in promoting cancer cell progression and is linked with DM. Cancer drug resistance and ototoxic effects can adversely affect the health and lifespan of an individual. However, naturally derived bioactive compounds are gaining attention for their nontoxic properties and specific behavior. Likewise, probiotics have also been regarded as safe and successful alternatives to treat DM‐linked cancers. The present review aims to highlight the therapeutic potential and feasible functions of probiotics to mitigate or inhibit DM‐associated cancers. Meanwhile, the intracellular signaling cascades involved in promoting DM‐linked cancer are enumerated for future prospective research. However, metabolomics interactions and protein–protein interactions are to be discussed for deeper insights into affirmative principles in diabetic‐linked cancers. Drug discovery and innovative preclinical evaluation need further adjuvant and immune‐enhancement therapies. Furthermore, the results of the in silico assessment could provide scientific excellence of IGF‐1 in diabetes and cancer. Overall, this review summarizes the mechanistic insights and therapeutic targets for diabetes‐associated cancer.

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Section: Probiotics Derived Secondary Metabolites With Immune‐enhanci...mentioning

confidence: 99%

Section: Effects Of Probiotics On Carcinogenesis Apoptosis and Antipr...mentioning

confidence: 99%

Feasible mechanisms and therapeutic potential of food probiotics to mitigate diabetes‐associated cancers: A comprehensive review and in silico validation

Vinothkanna,

Shi‐Liang,

Karthick Rajan

et al. 2024

Food Frontiers

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“…There is currently substantial evidence that probiotic supplementation could act as a protective agent against allergic symptoms, tumor malignancies, neurodegenerative and psychiatric diseases, cardiovascular diseases, obesity, diabetes, lactose intolerance, inflammatory bowel disease, immune system disorders, non-alcoholic fatty liver disease, diarrhea, irritable bowel syndrome, etc. [ 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. However, there is not at this time adequate conclusive evidence concerning their potential health effects, and it remains questionable whether they may be applied as supplementary treatment in any disease.…”

Section: Introductionmentioning

confidence: 99%

Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Poulios,

Pavlidou,

Papadopoulou

et al. 2024

Biology

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Background: Probiotics, as supplements or food ingredients, are considered to exert promising healthy effects when administered in adequate quantity. Probiotics’ healthy effects are related with the prevention of many diseases, as well as decreasing symptom severity. Currently, the most available data concerning their potential health effects are associated with metabolic disorders, including gestational diabetes mellitus. There is also clinical evidence supporting that they may exert beneficial effects against diverse adverse pregnancy outcomes. The purpose of the current narrative study is to extensively review and analyze the current existing clinical studies concerning the probable positive impacts of probiotics supplementation during pregnancy as a protective agent against adverse pregnancy outcomes beyond gestational diabetes mellitus. Methods: a comprehensive and thorough literature search was conducted in the most precise scientific databases, such as PubMed, Scopus, and Web of Sciences, utilizing efficient, representative, and appropriate keywords. Results: in the last few years, recent research has been conducted concerning the potential beneficial effects against several adverse pregnancy outcomes such as lipid metabolism dysregulation, gestational hypertensive disorders, preterm birth, excessive gestational weight gain, caesarean risk section, vaginal microbiota impairment, mental health disturbances, and others. Conclusion: up to the present day, there is only preliminary clinical data and not conclusive results for probiotics’ healthy effects during pregnancy, and it remains questionable whether they could be used as supplementary treatment against adverse pregnancy outcomes beyond gestational diabetes mellitus.

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Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response

Zhang,

Fu,

Leiliang

et al. 2024

Cancer Communications

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The intratumoral microbiome (TM) refers to the microorganisms in the tumor tissues, including bacteria, fungi, viruses, and so on, and is distinct from the gut microbiome and circulating microbiota. TM is strongly associated with tumorigenesis, progression, metastasis, and response to therapy. This paper highlights the current status of TM. Tract sources, adjacent normal tissue, circulatory system, and concomitant tumor co‐metastasis are the main origin of TM. The advanced techniques in TM analysis are comprehensively summarized. Besides, TM is involved in tumor progression through several mechanisms, including DNA damage, activation of oncogenic signaling pathways (phosphoinositide 3‐kinase [PI3K], signal transducer and activator of transcription [STAT], WNT/β‐catenin, and extracellular regulated protein kinases [ERK]), influence of cytokines and induce inflammatory responses, and interaction with the tumor microenvironment (anti‐tumor immunity, pro‐tumor immunity, and microbial‐derived metabolites). Moreover, promising directions of TM in tumor therapy include immunotherapy, chemotherapy, radiotherapy, the application of probiotics/prebiotics/synbiotics, fecal microbiome transplantation, engineered microbiota, phage therapy, and oncolytic virus therapy. The inherent challenges of clinical application are also summarized. This review provides a comprehensive landscape for analyzing TM, especially the TM‐related mechanisms and TM‐based treatment in cancer.

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Chemopreventive role of probiotics against cancer: a comprehensive mechanistic review

Cited by 7 publications

References 118 publications

Feasible mechanisms and therapeutic potential of food probiotics to mitigate diabetes‐associated cancers: A comprehensive review and in silico validation

Feasible mechanisms and therapeutic potential of food probiotics to mitigate diabetes‐associated cancers: A comprehensive review and in silico validation

Probiotics Supplementation during Pregnancy: Can They Exert Potential Beneficial Effects against Adverse Pregnancy Outcomes beyond Gestational Diabetes Mellitus?

Beyond the Gut: The intratumoral microbiome's influence on tumorigenesis and treatment response

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