Prevalence of gallbladder disease in diabetes mellitus

Chapman, B. A.; Wilson, Ian; Frampton, Christopher M.; Chisholm, Richard J.; Stewart, Neil R.; Eagar, G M; Allan, Richard B.

doi:10.1007/bf02071404

Cited by 99 publications

(85 citation statements)

References 29 publications

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“…Our findings are in agreement with previous cross-sectional and prospective studies of serum lipids and gallstones, which have consistently reported high triglycerides and low HDL in association with gallstone risk. [5][6][7]18,19 Paradoxical to the generally accepted association between hyperlipidemia and gallstones, we observed that lower levels of total cholesterol, LDL and apo B, characteristic of hypolipidemia, were also associated with biliary stones, independently of the other lipids and risk factors we examined. High levels of total cholesterol, LDL and apo B were not associated with biliary stones.…”

Section: Discussionmentioning

confidence: 99%

Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population‐based study in China

Andreotti

Chen

Gao

et al. 2007

Intl Journal of Cancer

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Biliary tract cancers, encompassing the gallbladder, extrahepatic bile ducts and ampulla of Vater, are rare but highly fatal malignancies. Gallstones, the predominant risk factor for biliary cancers, are linked with hyperlipidemia. As part of a populationbased case-control study conducted in Shanghai, China, we examined the associations of serum lipid levels with biliary stones and cancers. We included 460 biliary cancer cases (264 gallbladder, 141 extrahepatic bile duct, and 55 ampulla of Vater), 981 biliary stone cases and 858 healthy individuals randomly selected from the population. Participants completed an in-person interview and gave overnight fasting blood samples. Participants in the highest quintile of triglycerides (≥160 mg/dl) had a 1.4-fold risk of biliary stones (95% CI 5 1.1-1.9), a 1.9-fold risk of gallbladder cancer (95% CI 5 1.3-2.8), and a 4.8-fold risk of bile duct cancer (95% CI 5 2.8-8.1), compared to the reference group (third quintile: 90-124 mg/dl). Participants in the lowest quintile of high-density lipoprotein (HDL) (<30 mg/dl) had a 4.2-fold risk of biliary stones (95% CI 5 3.0-6.0), an 11.6-fold risk of gallbladder cancer (95% CI 5 7.3-18.5), and a 16.8-fold risk of bile duct cancer (95% CI 5 9.1-30.9), relative to the reference group (third quintile: 40-49 mg/dl). In addition, total cholesterol, low-density lipoprotein (LDL) and apolipoprotein A (apo A) were inversely associated with biliary stones; whereas low levels as well as high levels of total cholesterol, LDL, apo A and apolipoprotein B (apo B) were associated with excess risks of biliary tract cancers. Our findings support a role for serum lipids in gallstone development and biliary carcinogenesis. ' 2007 Wiley-Liss, Inc.Key words: serum lipid levels; gallstones; biliary tract cancer Biliary tract cancers, consisting of tumors of the gallbladder, extrahepatic bile ducts and ampulla of Vater, are rare but highly fatal malignancies. 1,2 Gallstones are the most important known risk factor for all three biliary tract cancer subsites. Specifically, cholesterol gallstones (composed mainly of cholesterol) and mixed gallstones (composed of both cholesterol and bilirubin) are most strongly associated with gallbladder cancer. 2,3 Furthermore, cholesterol gallstones and gallbladder cancer share a number of putative risk factors, including obesity, high fat diet and hyperlipidemia. 2,4 Hyperlipidemia is generally characterized by high serum levels of total cholesterol, triglycerides, low-density-lipoprotein (LDL), and low levels of high-density-lipoprotein (HDL). High triglycerides and low HDL have been most consistently associated with gallstones, whereas the associations of total cholesterol and LDL with gallstones are less consistent. [5][6][7] Cholesterol gallstone pathogenesis involves cholesterol saturation of the bile duct due to the hypersecretion of cholesterol from the liver 8 ; however, the exact role of individual lipids, lipoproteins and apolipoproteins is less clear.Given the relationship between hyperlipidemia and gallsto...

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Section: Discussionmentioning

confidence: 99%

Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population‐based study in China

Andreotti

Chen

Gao

et al. 2007

Intl Journal of Cancer

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“…The most common etiologies of acute pancreatitis accounting for 70-80% of cases are alcohol and gallstones. Chapman reported in 1996 a higher prevalence of gallstone disease based on ultrasound examination or report of cholecystectomy in diabetics (32.7%) compared to controls (20.8%, p<0.001) (Chapman, 1996). The difference was even greater for females were prevalence was 41.8% for female diabetic compared to controls 23.1% (p<0.001).…”

Section: Diabetes and Acute Pancreatitismentioning

confidence: 97%

“…Jorgensen failed to find an increased prevalence of gall stones in diabetic subjects in a Danish population after adjusting for obesity in a population not known for insulin resistance (Jorgensen). Chapman, in contrast, found an increased risk for gallstones in female diabetic subjects in New Zealand but no statistically increase in male diabetics after controlling for other know risk factors of BMI, HDL cholesterol, and TG, common comorbidities associated with type 2 diabetes (Chapman, 1996). Chapman reported increased gallbladder volume in type 2 diabetic subjects even without stones not seen in type 1 diabetics (Chapman 1998).…”

Section: Diabetes and Acute Pancreatitismentioning

confidence: 99%

Diabetes or Diabetes Drugs: A Cause for Acute Pancreatitis

Olansky¹

2012

Acute Pancreatitis

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“…A study from New Zealand reported a gallbladder stones prevalence of 32.7% among diabetic patients as compared to 20.8% in controls. 56 Another study from Italy showed that the prevalence of gallstone disease is significantly higher in diabetic patients than in the general population (24.8 vs. 13.8%). 57 The prevalence of gallstone was 40% among Libyan diabetic individuals and correlate positively with age and obesity.…”

Section: Cholesterol Gallstones and Renal Stone Disease And Diabetesmentioning

confidence: 97%

The association between renal stone disease and cholesterol gallstones: the easy to believe and not hard to retrieve theory of the metabolic syndrome

2014

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(2014) The association between renal stone disease and cholesterol gallstones: the easy to believe and not hard to retrieve theory of the metabolic syndrome, Renal Failure, 36:6,[957][958][959][960][961][962] AbstractRenal stone disease and gallstone disease are widely prevalent and costly disease across the globe. Both renal stone disease and gallstone disease are associated with a variety of diseases including obesity, metabolic syndrome, dyslipidemia, hypertension, insulin resistance diabetes and gout. Importantly, the presence of either renal stone disease or gallstone disease is associated with an increased risk of cardiovascular disease. In a recent study of the Atherosclerosis Risk in Communities (ARIC), individuals with a history of gallstones were 54% more likely to report a history of nephrolithiasis after adjusting for age, gender, body size and other factors. Furthermore, in three large cohorts including over 240,000 subjects: the Nurses' Health Studies (NHS) I and II and the Health Professionals Follow-up Study (HPFS), showed that gallstone disease is independently associated with nephrolithiasis. The mechanisms linking gallstone disease and renal stone disease are complex and not yet established. Insulin resistance, lithogenic diets, alterations of transporters in gallbladder and urinary system, and pH are possible potential mechanisms for future exploration. How the liver communicates with kidney in individuals with renal stone disease and gallstone disease is not well known and whether this communication is similar as in hepto-renal syndrome is subject for future research. Further research is needed to determine: (i) the underlying mechanisms of renal stone disease and gallstone disease; (ii) the potential treatment of renal stone disease and gallstone disease.

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Prevalence of gallbladder disease in diabetes mellitus

Cited by 99 publications

References 29 publications

Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population‐based study in China

Serum lipid levels and the risk of biliary tract cancers and biliary stones: A population‐based study in China

Diabetes or Diabetes Drugs: A Cause for Acute Pancreatitis

The association between renal stone disease and cholesterol gallstones: the easy to believe and not hard to retrieve theory of the metabolic syndrome

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