The association between renal stone disease and cholesterol gallstones: the easy to believe and not hard to retrieve theory of the metabolic syndrome

Ahmed, Mohamed H.; Barakat, Salma; Almobarak, Ahmed O.

doi:10.3109/0886022x.2014.900424

Cited by 19 publications

(21 citation statements)

References 63 publications

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“…Several genetic, metabolic and environmental factors for GD and CVD development have been identified. Environmental CVD risk factors include a sedentary lifestyle, a high-fat diet and cigarette smoking, which in turn have all been associated with GD (3,4). Certain lipid metabolizing genes have been identified as susceptibility genes for GD and CVD in genome-wide association studies or meta-analyses (5,6).…”

Section: Introductionmentioning

confidence: 99%

Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis

Zhao

Wang

et al. 2019

Exp Ther Med

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Increasing evidence connects gallstone disease (GD) to cardio-cerebrovascular disease (CVD). The aim of the present systematic review and meta-analysis was to determine whether and to what extent an association between GD and CVD existed. PubMed, EMBASE and the Cochrane Library were systemically searched up to March 3rd, 2018. A total of 10 studies (1,272,177 participants; 13,833 records; 5 prospective cohorts and 5 retrospective cohorts) were included. It was demonstrated that GD was associated with an increased risk of incidence [hazard ratio=1.24, 95% (CI) confidence interval: 1.17–1.31] and prevalence (unadjusted odds ratio=1.23, 95% CI: 1.21–1.25) of CVD. In conclusion, the presence of GD was associated with an increased risk of CVD incidence and prevalence. The association may be influenced by age and sex. These findings suggest that individuals identified with cardio-cerebrovascular disease should be evaluated for GD.

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Section: Introductionmentioning

confidence: 99%

Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis

Zhao

Wang

et al. 2019

Exp Ther Med

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“…Our results showed that Huashi Pill significantly increased the water and food intake and enhanced the pH values, which suggested the severity of renal stones was alleviated. In the other hand, the liver function also reflects the digestive function and indirectly affects the formation of renal stones [23]. Therefore, we examined the levels of ALT, AST, and TBIL in the renal rat model.…”

Section: Discussionmentioning

confidence: 99%

Inhibitive Effects of Huashi Pill on Formation of Renal Stones by Modulating Urine Biochemical Indexes and Osteopontin in Renal Stone Rat Models

YANG

Guo

et al. 2019

Med Sci Monit

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BackgroundRenal stones are the accumulated or deposited crystals that form and appear in supersaturated urine. This study aimed to the investigate the therapeutic effects of Huashi Pill on clearance of renal stones.Material/MethodsSprague Dawley rats were divided into normal control, positive control, low-dosage Huashi Pill, medium-dosage Huashi Pill, and high-dosage Huashi Pill groups. A renal rat model was established by using ethylene glycol, ammonium chloride, and calcium gluconate. The urinary pH, urine protein, and uric acid levels, as well as the calcium, magnesium, and phosphorus levels were examined. The blood urea nitrogen (BUN) and creatinine (Cr) levels were also evaluated. Aspartate aminotransferase (AST), alanine aminotransferase (ALT), and total bilirubin (TBIL) levels were evaluated. Crystal formation and calcium deposits were examined using hematoxylin and eosin (H and E) staining and von Kossa staining, respectively. Osteopontin (OPN) expression was evaluated with quantitative real-time polymerase chain reaction assay and immunohistochemical assay.ResultsA renal stone rat model was successfully established. Huashi Pill significantly improved water and food intake and enhanced pH value of urine (P<0.05). Huashi Pill significantly improved the liver functions by decreasing ALT and TBIL levels (P<0.05). Huashi Pill regulated the amounts of microelements. Huashi Pill significantly decreased the urine protein, uric acid, and Cr levels (P<0.05). Huashi Pill inhibited formation of stone crystals and reduced the insoluble calcium deposition. Huashi Pill significantly downregulated expression of OPN in the kidney tissues of renal rat models (P<0.05).ConclusionsHuashi Pill inhibited stone formation by regulating urine biochemical indexes and reducing OPN expression in kidney tissue in a renal stone rat model.

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“…Non-alcoholic liver disease and gallstone disease have previously been shown to be associated with kidney stones. 23 – 25 The mechanisms linking these diseases with kidney stones are complex and not yet established. In our study, patients with preexisting liver and gall bladder diseases where excluded, and it cannot be ruled out that persisting changes in urinary constituents predispose to liver reactions.…”

Section: Discussionmentioning

confidence: 99%

Clinical factors predicting drug-induced liver injury due to flucloxacillin

Lindh¹,

Hallberg²,

Yue³

et al. 2018

DHPS

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ObjectivesDrug-induced liver injury (DILI) is a serious adverse reaction due to flucloxacillin. The pathogenesis is not fully understood. Female sex, age over 60 years, and a longer treatment duration have been suggested to be predisposing factors. Carriers of HLA-B*57:01 have an 80-fold increased risk, but due to the rarity of the reaction, testing of all patients is not cost-effective. We aimed to validate and detect clinical risk factors for flucloxacillin DILI.MethodsClinical characteristics of flucloxacillin-treated patients with (n=50) and without DILI (n=2,330) were compared in a retrospective case control study. Cases were recruited from the Swedish database of spontaneously reported adverse drug reactions. Treated controls were selected from the Swedish Twin Registry. Statistical comparisons were made using chi-squared test and logistic regression. The significance threshold was set to P<0.00357 to correct for multiple comparisons. Reliable variables were tested in a multiple regression model.ResultsDILI was associated with female sex, OR 2.79, 95% CI 1.50–5.17, P=0.0011, and with a history of kidney stones, OR 5.51, 95% CI 2.21–13.72, P=0.0003. Cases were younger than controls, OR per increase in years 0.91, 95% CI 0.88–0.94, P<0.0001, probably due to selection bias. No difference in treatment duration was detected, OR 1.03, 95% CI 0.98–1.08, P=0.1790.ConclusionWe established female sex as a risk factor for flucloxacillin-induced DILI, and a history of kidney stones was identified as a potential risk factor. Clinical risk factors for flucloxacillin-induced DILI could be used to indicate whom to test for HLA-B*57:01 before treatment.

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The association between renal stone disease and cholesterol gallstones: the easy to believe and not hard to retrieve theory of the metabolic syndrome

Cited by 19 publications

References 63 publications

Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis

Association between gallstone and cardio‑cerebrovascular disease: Systematic review and meta‑analysis

Inhibitive Effects of Huashi Pill on Formation of Renal Stones by Modulating Urine Biochemical Indexes and Osteopontin in Renal Stone Rat Models

Clinical factors predicting drug-induced liver injury due to flucloxacillin

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