Prevalence of Enterobacteriaceae spp. and its multidrug-resistant rates in clinical isolates: A two-center cross-sectional study

Mirzaei, Bahman; Babaei, Ryhane; Bazgir, Zahra Norouzi; Goli, Hamid Reza; Keshavarzi, Shima; Amiri, Elham

doi:10.1007/s11033-020-06114-x

Cited by 12 publications

(8 citation statements)

References 14 publications

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“…However, there are many studies that showed isolation of Enterobacterales, non-fermenting P. aeruginosa and A. baumannii from clinical samples and established infection from rectal colonization. [34][35][36][37] Some studies from Mongolia also showed presence of extended-spectrum β-lactamase-producing E. coli, Klebsiella spp. and A. baumannii from clinical samples.…”

Section: Discussionmentioning

confidence: 99%

High Acquisition Rate of Gram-Negative Multi-Drug Resistant Organism Colonization During Hospitalization: A Perspective from a High Endemic Setting

Baljin

Gurjav

Khosbayar

et al. 2021

IDR

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Objective The aim of the study was to compare the rate of gram-negative multi-drug resistant organism (GN-MDRO) colonization at admission and during hospitalization and to describe the strains and antibiotic resistance genes acquired during hospitalization. Methods Rectal swabs were collected from patients hospitalized at the National Trauma Center (NTC), Mongolia, at the time of admission and after 14 days of hospitalization as has been detailed on our previous study. GN-MDRO antibiotic resistance was determined using EUCAST standards, and resistance genes were detected using multiplex PCR. Results A total of 158 patients were screened, and baseline colonization rate at admission was 29.1% (46/158). The rate went up to 69.9% (110/158) after 14 days of hospitalization (p<0.001). Of all participants, 74 patients (46.8%) screened GN-MDRO negative at admission acquired colonization by day 14. Other 36 patients (22.8%) maintained colonization that was screened positive at both time points. Only 38 patients (24.0%) remained free of GN-MDRO during hospitalization. There was a difference in GN-MDRO acquisition between these groups. Patients who were negative at admission acquired up to 3 GN-MDRO species, and there were 10 different species isolated. Reversely, patients who were screened positive at both time points had fairly homogenous isolates; up to 5 species of Enterobacterales were identified at admission and day 14 hospitalization. Overall, Enterobacterales were the dominant colonizers (61.4%, 97/158), and all Enterobacterales were resistant to cefotaxime as CTX-M resistance was our inclusion criteria. Conclusion GN-MDRO baseline colonization rate on admission was high and, alarmingly, doubled during hospitalization in the study area. Enterobacterales was the predominant colonizer and was highly resistant to 3rd generation cephalosporin. This data supports a need for an improved infection control policy including routine surveillance of the GN-MDROs and improved antibiotic stewardship program.

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Section: Discussionmentioning

confidence: 99%

High Acquisition Rate of Gram-Negative Multi-Drug Resistant Organism Colonization During Hospitalization: A Perspective from a High Endemic Setting

Baljin

Gurjav

Khosbayar

et al. 2021

IDR

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“…Exposure wounds are vulnerable to infection with Enterobacte r spp., especially MDR- Enterobacter spp., which was consistent with our results. 32 , 33 ; Moreover, burn patients with MDR- Enterobacter spp. infections may develop sepsis, multi-organ failure, and even death owing to inappropriate empirical antibiotic therapy.…”

Section: Discussionmentioning

confidence: 99%

Pathogenic Characteristics and Risk Factors for ESKAPE Pathogens Infection in Burn Patients

Xie

Yang

et al. 2021

IDR

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“…Genes coding for ESBLs are carried on bacterial chromosomes and can move among bacterial population either by inheritance or by plasmids 20 . Such drug resistant pathogens are of great concern, as they cause fatal infections and increases the duration of hospitalization, thereby increasing the cost of treatment 21 . The prevalence of ESBL producing bacteria varies worldwide.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Extended Spectrum Beta-Lactamase Producing Gram-Negative Bacilli causing Surgical Site Infections in a Tertiary Care Centre

Madhavi¹,

Hanumanthappa²

2021

J. Pure Appl. Microbiol.

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Hospital-acquired infections (HAIs) are continuing to be a major risk in health care settings. World Health Organization (WHO) describes surgical site infections (SSIs) as one among the major health issue, causing enormous burden to both patients as well as doctors. Multidrug-resistant pathogens that cause SSIs continue to be an ongoing and increasing challenge to health care settings. The objective of the present study was to know the prevalence of extended-spectrum beta-lactamase (ESBL) producing gram-negative bacilli causing SSIs at a tertiary healthcare facility. The present cross-sectional observational study was done for a period of one year. Pus samples from clinically suspected cases of SSIs were collected and subjected to bacterial culture and sensitivity testing. From the total of 140 samples collected, a total of 138 bacterial isolates were isolated. Out of 138 isolates, 85 isolates (61.6%) were identified as gram-negative bacilli of which 33 isolates (38.8%) were identified to be ESBL phenotypes. The majority of the ESBL phenotypes were Escherichia coli (25.9%) followed by Klebsiella pneumoniae (7%), Acinetobacter species (2.4%), Pseudomonas aeruginosa (2.4%) and Proteus species (1.2%). Regular surveillance of antibiotic sensitivity pattern and screening for beta-lactamase production should be done which helps to know the trends of pathogenic bacteria causing SSI and guides in planning antibiotic therapy.

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Prevalence of Enterobacteriaceae spp. and its multidrug-resistant rates in clinical isolates: A two-center cross-sectional study

Cited by 12 publications

References 14 publications

High Acquisition Rate of Gram-Negative Multi-Drug Resistant Organism Colonization During Hospitalization: A Perspective from a High Endemic Setting

High Acquisition Rate of Gram-Negative Multi-Drug Resistant Organism Colonization During Hospitalization: A Perspective from a High Endemic Setting

Pathogenic Characteristics and Risk Factors for ESKAPE Pathogens Infection in Burn Patients

Prevalence of Extended Spectrum Beta-Lactamase Producing Gram-Negative Bacilli causing Surgical Site Infections in a Tertiary Care Centre

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