Pathogenic Characteristics and Risk Factors for ESKAPE Pathogens Infection in Burn Patients

Li, Zhaoyinqian; Xie, Jingling; Yang, Jiaxin; Liu, Siyi; Ding, Zixuan; Hao, Jingchen; Ding, Yinhuan; Zeng, Zhangrui; Wang, Zhibin

doi:10.2147/idr.s338627

Cited by 10 publications

(6 citation statements)

References 42 publications

(47 reference statements)

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“…This finding raises concerns that ESKAPE contamination in Romania may not be strictly correlated with hospitalisation contamination and that ESKAPE pathogens are widespread throughout the community and environment, as confirmed by the literature that describes the emergence of environmental ESKAPE as both sensitive and MDR outside the hospital setting [29,30]. ESKAPE pathogens have been reported to account for 50% of all bacteria isolated from burn patients [31]. In our study, 75% of patients presented an ESKAPE specimen.…”

Section: Bacteria Resistance Phenotypessupporting

confidence: 75%

Antimicrobial Resistance of Eskape Pathogens in Major Burns Patients – One-Year Retrospective Study

HODEA¹

2023

FARMACIA

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Infections in patients with major burns are among the most frequent causes of complications and an increase in mortality. In particular, a group of bacteria abbreviated ESKAPE, consisting of Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacter species, has increasingly become problematic in recent times due to their fast capacity to develop antibiotic resistance. The aim of this study was to analyse ESKAPE pathogens from the Major Burn Units in Clinical Emergency Hospital Bucharest through a retrospective crosssectional study, given the high mortality rate of these patients. Our findings revealed that a large percentage (75%) of patients presented with an ESKAPE pathogen during either direct admission or transfer from another healthcare unit; however, this did not influence mortality. The most frequent isolate was Staphylococcus aureus; however, Acinetobacter baumannii had the highest tendency to develop multidrug or extensive-drug resistance. In particular, ESKAPE bacteria tended to exhibit higher antibiotic resistance properties, as there were more ESKAPE MDR and XDR variants than non-ESKAPE strains. RezumatInfecțiile au fost printre cele mai frecvente cauze ale complicațiilor și mortalității crescute în cazul pacienților cu arsuri grave. În particular, un grup de bacterii abreviat ESKAPE, din care fac parte Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumanii, Pseudomonas aeruginosa și speciile genului Enterobacter, a devenit din ce în ce mai problematic în zilele noastre, din cauza capacității lor rapide de a dezvolta rezistență la antibiotice. Scopul acestei lucrări este de a analiza agenții patogeni ESKAPE din Centrul de Arși Grav al Spitalului Clinic de Urgență București, realizând un studiu retrospectiv de tip "cross-sectional" având în vedere mortalitatea ridicată a acestor pacienți. În urma acestui studiu, rezultatele arată că o mare parte dintre pacienți (75%) prezintă un agent patogen ESKAPE fie la admisia directă în spital, fie la admisia prin transfer dintr-o altă unitate spitalicească, fără a influența mortalitatea. Cea mai frecvent izolată bacterie a fost Staphylococcus aureus, în timp ce Acinetobacter baumanii a prezentat cea mai mare tendință de a dezvolta rezistență antibiotică de tip "multi-drug" sau "extensive-drug". O descoperire particulară a fost că bacteriile ESKAPE tind să prezinte proprietăți de rezistență antibiotică mai dezvoltate, întrucât au fost mai multe variante MDR și XDR ESKAPE, comparativ cu bacteriile non-ESKAPE.

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Section: Bacteria Resistance Phenotypessupporting

confidence: 75%

Antimicrobial Resistance of Eskape Pathogens in Major Burns Patients – One-Year Retrospective Study

HODEA¹

2023

FARMACIA

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“…A database analysis in the United States conducted by Marturano and Lowery in 2019 [ 23 ] showed that ESKAPE pathogens represented 42.2% of total bloodstream infections. These results coincide with the Department of Plastic and Burn Surgery of the Affiliated Hospital of Southwest Medical University in Luzhou, China, informing us that 47.5% of bacterial isolates from burn patients corresponded to the ESKAPE group [ 24 ]. Furthermore, 55% of these isolates were identified as multidrug resistant (MDR).…”

Section: Antibiotic Bacterial Resistance: a Serious And Multidiscipli...supporting

confidence: 77%

Facing Resistant Bacteria with Plant Essential Oils: Reviewing the Oregano Case

et al. 2022

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Antibiotic resistance is a serious global threat, and the misuse of antibiotics is considered its main cause. It is characterized by the expression of bacterial defense mechanisms, e.g., β-lactamases, expulsion pumps, and biofilm development. Acinetobacter baumannii and Pseudomonas aeruginosa are antibiotic-resistant species that cause high morbidity and mortality. Several alternatives are proposed to defeat antibiotic resistance, including antimicrobial peptides, bacteriophages, and plant compounds. Terpenes from different plant essential oils have proven antimicrobial action against pathogenic bacteria, and evidence is being generated about their effect against antibiotic-resistant species. That is the case for oregano essential oil (Lippia graveolens), whose antibacterial effect is widely attributed to carvacrol, its main component; however, minor constituents could have an important contribution. The analyzed evidence reveals that most antibacterial evaluations have been performed on single species; however, it is necessary to analyze their activity against multispecies systems. Hence, another alternative is using plant compounds to inactivate hydrolytic enzymes and biofilms to potentiate antibiotics’ effects. Despite the promising results of plant terpenes, more extensive and deep mechanistic studies are needed involving antibiotic-resistant multispecies to understand their full potential against this problem.

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“…The ESKAPE group was selected as the "priority state". 16 Although many studies have reported the risk factors of diabetic foot infection, 17,18 the characteristics of patients with diabetic foot infection caused by specific ESKAPE pathogens are still unknown. Therefore, the purpose of this study is to investigate the clinical manifestations, antimicrobial resistance, and risk factors for ESKAPE infection in patients with DFUs in southwest China.…”

Section: Introductionmentioning

confidence: 99%

Cigarette Smoking and Peripheral Vascular Disease are Associated with Increasing Risk of ESKAPE Pathogen Infection in Diabetic Foot Ulcers

Li¹,

Li²,

Li³

et al. 2022

DMSO

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Objective Diabetic foot ulcers (DFUs) and ESKAPE pathogens have attracted attention globally, but the role of ESKAPE pathogens in diabetic foot infection is not well described. The purpose of this study was to evaluate the clinical features, antimicrobial resistance, and risk factors for ESKAPE infection in patients with DFUs. Methods A retrospective study was conducted on 180 patients with diabetic foot infection admitted to The Affiliated Hospital of Southwest Medical University (Luzhou, China), from January 2017 to April 2021. Antimicrobial susceptibilities of all isolates were determined. Multivariate logistic regression analysis was performed to analyze the independent risk factors for ESKAPE infection, multidrug-resistant (MDR)-ESKAPE infection, MDR-pathogen infection, and severe group in patients with DFUs. Results A total of 206 isolates were collected, of which 42.2% were ESKAPE pathogens. The independent risk factors for ESKAPE infection were cigarette smoking (OR = 1.958; 95% CI, 1.015–3.777) and peripheral vascular disease (OR = 2.096; 95% CI, 1.100–3.992), while alcohol consumption (OR = 2.172; 95% CI, 1.104–4.272) was the independent risk factor for MDR-pathogen infection. Additionally, the independent risk factors for severe DFU group were invasive treatment (OR = 326.642; 95% CI, 76.644–1392.08), the duration of systemic antibiotic treatment (OR = 0.918; 95% CI, 0.849–0.992), and length of hospital stay (OR = 1.145; 95% CI, 1.043–1.256). No independent risk factors for MDR-ESKAPE infection were found. Conclusion Our data established the microbiological features of ESKAPE pathogens and clinical manifestations of diabetic foot infection, and provide support for monitoring and management of ESKAPE infection in patients with DFUs in southwest China.

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Pathogenic Characteristics and Risk Factors for ESKAPE Pathogens Infection in Burn Patients

Cited by 10 publications

References 42 publications

Antimicrobial Resistance of Eskape Pathogens in Major Burns Patients – One-Year Retrospective Study

Antimicrobial Resistance of Eskape Pathogens in Major Burns Patients – One-Year Retrospective Study

Facing Resistant Bacteria with Plant Essential Oils: Reviewing the Oregano Case

Cigarette Smoking and Peripheral Vascular Disease are Associated with Increasing Risk of ESKAPE Pathogen Infection in Diabetic Foot Ulcers

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