Prevalence of dry eye disease and its association with dyslipidemia

Krishnamoorthy, Rajagopal; Kaliaperumal, Ramachandran; Baba, Durairaj; Ramesh, V.; Anebaracy, Velusamy; Vidhya, R.; Rajamanickam, Vinothkumar; Poovitha, R; Rv, Geetha

doi:10.1515/jbcpp-2017-0001

Cited by 28 publications

(29 citation statements)

References 21 publications

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“…In the current study, there was a significant association between DED and DM2 ( P =0.003) as well as DED and DM1 ( P =0.003), which corresponds with earlier studies for DM217,30,31 and for DM1 16. Of particular interest was our finding that there was a higher DED prevalence in those with DM2 (56% by OSDI) than for DM1 (27%).…”

Section: Discussionsupporting

confidence: 92%

“…Of particular interest was our finding that there was a higher DED prevalence in those with DM2 (56% by OSDI) than for DM1 (27%). In our study, the prevalence of DM2-associated DED was comparable to other reports on DM2 cohorts, such as Manaviat et al30 (54.3%; determined by tear break-up time [TBUT] and Schirmer test) and Rathnakumar et al31 (53%, TBUT and Schirmer test), but was higher than that reported by Najafi et al4,32 (27.7%, as determined by tear osmolarity). This difference between our findings and Najafi et al4 might be due to the fact that in long-standing diabetes, patients with higher tear osmolarity often experience fewer dry eye symptoms 3.…”

Section: Discussionsupporting

confidence: 88%

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Patient-reported severity of dry eye and quality of life in diabetes

Yazdani-Ibn-Taz¹,

Han²,

Jonuscheit³

et al. 2019

OPTH

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PurposeThe purpose of the study was to assess the relationship between patient-reported severity of dry eye disease (DED), quality of life (QoL), presence of diabetic retinopathy (DR) and length of disease duration in people with type 1 diabetes mellitus (DM1) and type 2 diabetes mellitus (DM2).Patients and methodsA survey of 152 people (110 with and 42 without diabetes). All participants completed the Ocular Surface Disease Index (OSDI) and Dry Eye-related Quality of Life Score (DEQS) questionnaires.ResultsForty-four percent of all diabetic subjects reported dry eye symptoms, compared to 29% in the control group. Patients with DM2 reported dry eye symptoms more frequently than those with DM1 (55% and 27% respectively, P=0.001). Dry eye severity was linked to a significant deterioration in QoL in both types of diabetes (DM1, r=0.609 and P=0.036; DM2, r=0.417 and P=0.011). Irrespective of DR, the presence of DED was significantly higher in DM2 compared to DM1 (with DR, P=0.011; without DR, P=0.018).ConclusionDry eye symptoms are associated with reduced QoL and are more common in people with DM2 than in DM1, irrespective of DR status. Routine clinical screening for severe DED could potentially allow for a timely and more effective treatment and could contribute to mitigating the dry eye-associated reduction in QoL in those with DM2.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 88%

Patient-reported severity of dry eye and quality of life in diabetes

Yazdani-Ibn-Taz¹,

Han²,

Jonuscheit³

et al. 2019

OPTH

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“…HDL has been associated with increased levels of anti-inflammatory cytokines such as interleukin 10 (IL-10), that reduce production of pro-inflammatory agents such as IL-6 and tumor necrosis factor receptors, thereby inhibiting cell growth and proliferation as well as promoting apoptosis 25–27. In addition, HDL levels are closely related to age-related macular degeneration (AMD),30–32 dry eye (DE),33,34 and cardiovascular disease (CVD) 35. And some reports have suggested that high HDL levels are associated with an increased risk of AMD30–32 whereas low HDL levels are relevant to DE and CVD 33–35.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, HDL levels are closely related to age-related macular degeneration (AMD),30–32 dry eye (DE),33,34 and cardiovascular disease (CVD) 35. And some reports have suggested that high HDL levels are associated with an increased risk of AMD30–32 whereas low HDL levels are relevant to DE and CVD 33–35. In our study, the CRC patients with ocular metastases had increased serum levels of HDL, which is opposite to the correlation between HDL and the incidence of CRC, but in line with the changes in some ocular diseases.…”

Section: Discussionmentioning

confidence: 99%

The predictive value of high-density lipoprotein for ocular metastases in colorectal cancer patients

Zhu

Gong

Min

et al. 2019

CMAR

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Purpose: Colorectal cancer (CRC) is a common tumor of the digestive tract that tends to metastasize and leads to high mortality. Ocular metastases (OM) from colorectal cancer are being increasingly diagnosed, and they can lead to a poor prognosis. Serum lipids are a known risk factor for cardiovascular disease, and are also relevant to the occurrence of CRC. In this study, we examined the levels of serum lipids and tried to determine whether there were correlations with the occurrence of OM in patients with colorectal cancer, in order to determine whether serum lipid levels may be a risk factor for OM in this patient population. Patients and methods: Records from a total of 703 patients treated for colorectal cancer from August 2005 to August 2017 were involved in this study. Student’s t -tests, nonparametric rank sum tests, and Chi-square tests were applied to describe whether there were significant differences between the OM group and non-ocular metastases (NOM) group. We used binary logistic regression analysis to determine the risk factors and receiver operating curve (ROC) analyses to assess the diagnostic value for OM in CRC patients. Results: There were no significant differences in gender, age, histopathology type, or tumor classifications between the OM and NOM groups. The levels of serum TC, HDL, and LDL were significantly different between patients with and without lymph node metastases as well as male and female patients. The OM group had higher serum HDL levels compared to the NOM group. Binary logistic regression indicated that HDL was a risk factor for OM in colorectal cancer patients. The ROC curves showed that the AUC of HDL was 0.660. The cutoff value of HDL was 1.27 mmol/L, with a sensitivity of 0.619 and a specificity of 0.650. Conclusion: HDL levels are correlated with ocular metastases in colorectal cancer patients.

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“…Diabetes mellitus (DM) can cause many ocular complications such as keratoconjunctivitis, retinopathy, dry eye disease (DED), cataract, nerve palsies, glaucoma and macular edema. In recent years, in addition to diabetic retinopathy has received widespread attention for its role in causing blindness, the dry eye problem also has generated attention for its high incidence in diabetics [1,2].…”

Section: Introductionmentioning

confidence: 99%

The role of inflammatory cytokines in dry eye in type 2 diabetic patients

Cui

Ren

et al. 2019

Preprint

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Background The aim of this study was to explore the relationship between the ocular surface characteristics and the levels of tear and conjunctiva inflammatory cytokines. Methods This study enrolled 102 diabetes patients with dry eye (DE) and 117 volunteers. All enrolled subjects were tested in the following sequence: Ocular surface disease index (OSDI) was self-answered and ocular surface characteristics including Schirmer I test (SIt), tear-film breakup time (BUT), and corneal fluorecein staining (CFS) were evaluated. Levels of transforming growth factor (TGF)-β1, nuclear factor-κB (NF-κB), and interleukin-17 (IL-17) were measured in the conjunctiva using a multiplex immunobead assay. Periodicacid-Schiff (PAS) staining, immunohistochemistry, enzyme-linked immunosorbent assay (ELISA) and flow cytometry were also performed. Spearman correlations between cytokines and ocular surface parameters were calculate. Results The ELISA results showed that the levels of IL-lβ and TNF-α in the DE patients with diabetes group were significantly higher than those in the normal group (P < 0.001 and P = 0.023). The immunohistochemical staining results and western-blot results showed that the expression levels of TGF-β1 and NF-κB in the conjunctiva in the diabetes mellitus group were significantly increased compared to those in the normal group. The flow cytometric results showed that the expression levels of CCR6 and IL-17 were significantly increased in diabetes mellitus group compared to the normal group (P < 0.001 and P < 0.001). Conclusions Inflammatory cytokines were highly expressed in the conjunctiva and tears of diabetic patients with dry eye. The mechanism for this might be related to hyperglycemia-induced activation of the NF-κB pathway, which increased the levels of inflammatory cytokines. In addition, chemokines might also play a role in the pathogenesis of dry eye in diabetes mellitus.

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Prevalence of dry eye disease and its association with dyslipidemia

Cited by 28 publications

References 21 publications

<p>Patient-reported severity of dry eye and quality of life in diabetes</p>

<p>Patient-reported severity of dry eye and quality of life in diabetes</p>

<p>The predictive value of high-density lipoprotein for ocular metastases in colorectal cancer patients</p>

The role of inflammatory cytokines in dry eye in type 2 diabetic patients

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