<p>The predictive value of high-density lipoprotein for ocular metastases in colorectal cancer patients</p>

Abstract

Purpose: Colorectal cancer (CRC) is a common tumor of the digestive tract that tends to metastasize and leads to high mortality. Ocular metastases (OM) from colorectal cancer are being increasingly diagnosed, and they can lead to a poor prognosis. Serum lipids are a known risk factor for cardiovascular disease, and are also relevant to the occurrence of CRC. In this study, we examined the levels of serum lipids and tried to determine whether there were correlations with the occurrence of OM in patients with colorectal cancer, in order to determine whether serum lipid levels may be a risk factor for OM in this patient population. Patients and methods: Records from a total of 703 patients treated for colorectal cancer from August 2005 to August 2017 were involved in this study. Student’s t -tests, nonparametric rank sum tests, and Chi-square tests were applied to describe whether there were significant differences between the OM group and non-ocular metastases (NOM) group. We used binary logistic regression analysis to determine the risk factors and receiver operating curve (ROC) analyses to assess the diagnostic value for OM in CRC patients. Results: There were no significant differences in gender, age, histopathology type, or tumor classifications between the OM and NOM groups. The levels of serum TC, HDL, and LDL were significantly different between patients with and without lymph node metastases as well as male and female patients. The OM group had higher serum HDL levels compared to the NOM group. Binary logistic regression indicated that HDL was a risk factor for OM in colorectal cancer patients. The ROC curves showed that the AUC of HDL was 0.660. The cutoff value of HDL was 1.27 mmol/L, with a sensitivity of 0.619 and a specificity of 0.650. Conclusion: HDL levels are correlated with ocular metastases in colorectal cancer patients.

The predictive value of serum lipids for eye metastases in male nasopharyngeal carcinoma patients

“…As mentioned above, those may provide potential mechanisms for the differences of serum lipid levels in male NPC patients with or without eye metastasis, for example, through exosomes or miRNA [51]. The inner mechanisms are thought-provoking, and our team have been studying the risk factors of eye metastasis of many different cancers, we once found high-density lipoprotein can be a sensitive index for eye metastases in colorectal cancer patients [52]. Our study aims to find sensitive serological markers as an auxiliary reference standard for early diagnosis of eye metastasis of nasopharyngeal carcinoma.…”

Risk factors and their diagnostic values for ocular metastases in invasive ductal carcinoma

“…Risk factors obtained by the statistical analysis were useful to predict distant metastases in clinical practice. Studies of risk factors for various metastases are summarized in Table 5 5,6,9‐12 …”

“…Studies of risk factors for various metastases are summarized in Table 5. 5,6,[9][10][11][12] In the present retrospective study, we explored the risk factors for OM in 1192 patients with IDC and analyzed their diagnostic values. As patients in the OM group were more likely to have other metastases and their diseases were also in advanced stages, they often had poor prognosis.…”

Revealing the Role of High-Density Lipoprotein in Colorectal Cancer

“…In a study by Healy et al [ 21 ], the serum HDL-C level was significantly associated with a more advanced pathological stage of CRC and lymph node involvement. Other studies have found no difference in HDL-C levels among CRC patients with and without distant metastases [ 22 ], or even increased HDL-C levels in those with ocular metastases [ 23 ].…”