Prevalence of double diabetes in youth onset diabetes patients from east Delhi and neighboring NCR region

Mishra, B.K.; Shukla, Pramod Shankar; Aslam, Mohd; Siddiqui, Azaz; Madhu, Sri Venkata

doi:10.1016/j.dsx.2017.08.016

Cited by 10 publications

(7 citation statements)

References 12 publications

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“…DD potentiates the risk of micro and macrovascular complications of diabetes. As the insulin resistance and weight gain are the main clinical features of DD, the treatment regimen would include the weight reduction and insulin titration approach to use a proper dose of insulin [8][9][10][11].…”

Section: Double Diabetes (Dd)mentioning

confidence: 99%

A Review on Role of Markers in Diabetes Mellitus and Associated Micro and Macrovascular Complications

KAMALESH

Geetha

2022

Int J Curr Pharm Sci

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Diabetes mellitus is one of the leading metabolic disorders in the last few decades, affecting the larger population of the world in both developed and developing countries. In diabetes mellitus there is reduced secretion and/or action leading to disturbance in the metabolism of glucose. The prolonged hyperglycemia causes several microvascular and macrovascular complications, which are the leading cause of death. Although the prevalence of diabetes is high, the majority of the people remain undiagnosed, which leads to complications. The diagnosis of diabetes involves the measurement of blood glucose levels. Several biochemical and body components regulate the secretion and action of insulin. Therefore, they serve as biomarkers for the diagnosis of diabetes mellitus. The biomarkers like HbA1C, glycated albumin, fructosamine, ferritin, fetuin-A, ceramides, HDL cholesterol, calprotectin, Acylcarnitine and micro RNA are some of the important biomarkers for diabetes mellitus. Through this review, we have made an attempt to describe the role and significance of biomarkers for diabetes mellitus.

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Section: Double Diabetes (Dd)mentioning

confidence: 99%

A Review on Role of Markers in Diabetes Mellitus and Associated Micro and Macrovascular Complications

KAMALESH

Geetha

2022

Int J Curr Pharm Sci

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“…Moreover, the rate of complications even in a well-controlled DD subgroup is reported to be higher than in all those with T1D without MS, regardless of glycaemic control. [ 4 , 5 ] Insulin resistance (IR) and obesity are regarded as common presentations of DD in subjects with T1D. Due to the lack of awareness of metabolic comorbidities in T1D, identification and treatment of MS in T1D are extremely difficult.…”

Section: Introductionmentioning

confidence: 99%

Role of Dietary Macronutrient Composition and Fibre Intake in Development of Double Diabetes in Indian Youth

Oza,

Mandlik,

Khadilkar

et al. 2024

Indian Journal of Endocrinology and Metabolism

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Introduction: Insulin resistance (IR) and obesity are common presentations of double diabetes (DD) in subjects with type-1 diabetes (T1D). There is evidence that dietary composition has an impact on developing IR. Objectives were to assess the impact of macronutrient and fibre intake on glycaemic control and the role of macronutrient composition of diet in the development of DD in subjects with T1D. Methods: This cross-sectional study included 77 young adults (10–25 years) with T1D. Data related to demography, anthropometry, biochemistry and body composition were collected. Dietary data was collected by fourteen-day food diary. IR was calculated using eGDR, SEARCH and CACTI equations, and metabolic syndrome (MS) was diagnosed using the International Diabetes Federation Consensus Definition. Results: Subjects at risk of DD had higher age, leptin levels, percentage carbohydrate consumption in diet and IR. A positive association of insulin sensitivity with fibre intake and %protein intake was noted. Poor glycaemic control, adiponectin/leptin ratio, fibre intake and insulin/carbohydrate ratio were significant negative predictors of IR. Addition of dietary factors to the regression model improved the R square and percentage of subjects identified correctly. Inclusion of dietary parameters significantly improves the prediction of the risk of development of DD in subjects with T1D. Conclusion: Good glycaemic control and increased intake of dietary fibre may prevent the development of IR in subjects with T1D and reduce the burden of DD.

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“…[ 4 ] A study from North India labelled 7% subjects as having double diabetes, whereas a study from South India reported 22.2% prevalence of MS in their T1D population. [ 5 , 6 ]…”

Section: Introductionmentioning

confidence: 99%

A Pilot Study to Assess Effect of Metformin Therapy on Prevention of Double Diabetes in Indian Adolescents with Type-1 Diabetes

Khadilkar

Oza

Mondkar

et al. 2023

Indian Journal of Endocrinology and Metabolism

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Introduction: Increased prevalence of metabolic syndrome in Indian adolescents owing to the obesity epidemic leads to double diabetes (DD), which is associated with an increased risk of complications in type-1 diabetes (T1D). Metformin may be a useful intervention for the prevention and treatment of insulin resistance in T1D. We conducted this pilot randomized controlled trial with the objective of investigating the effect of metformin on insulin sensitivity in Indian adolescents with T1D. Method: This pilot randomized controlled trial was performed on 59 participants with T1D aged 10–19 years distributed uniformly by gender and puberty across two groups with a 3-month intervention period. The intervention group received metformin (weight less than 60 kg received 500 mg twice daily and more than 60 kg received 1 gm twice daily) and non-metformin group received standard of care for diabetes. Anthropometric, clinical details, biochemistry and insulin sensitivity indices (ISI) were evaluated using standard protocols at baseline and endline. Result: 22.2% of subjects from non-metformin group and 12.5% from metformin group were at the risk of the development of DD. The odds ratio and relative risk for the development of DD in non-metformin subjects were 2.0 and 1.4, respectively, as compared to participants in metformin group. The mean improvement in ISI ranged from 1.4% to 4.6% in participants on metformin as opposed to deterioration of -2% to -14.1% in non-metformin group. On performing the paired sample t-test, the reduction in ISI in non-metformin group was significant. Conclusion: Metformin may prevent deterioration in insulin sensitivity in Indian adolescents with T1D.

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Prevalence of double diabetes in youth onset diabetes patients from east Delhi and neighboring NCR region

Cited by 10 publications

References 12 publications

A Review on Role of Markers in Diabetes Mellitus and Associated Micro and Macrovascular Complications

A Review on Role of Markers in Diabetes Mellitus and Associated Micro and Macrovascular Complications

Role of Dietary Macronutrient Composition and Fibre Intake in Development of Double Diabetes in Indian Youth

A Pilot Study to Assess Effect of Metformin Therapy on Prevention of Double Diabetes in Indian Adolescents with Type-1 Diabetes

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