Prevalence of Diabetic Neuropathy in Young Adults with Type 1 Diabetes and the Association with Insulin Pump Therapy

Christensen, Marie Mathilde Bjerg; Hommel, E.; Jørgensen, Marit Eika; Scholten, Bernt Johan von; Fleischer, Jesper; Hansen, Christian Stevns

doi:10.1089/dia.2018.0249

Cited by 16 publications

(16 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The results of the prevalence of DSPN and CAN have been discussed elsewhere ( 4 ). In total, 51.1% ( n = 68) were diagnosed with subclinical DSPN.…”

Section: Resultsmentioning

confidence: 99%

“…The study was designed as a cross-sectional observational study. The structure has been described in detail previously (4).…”

Section: Study Populationmentioning

confidence: 99%

“…It is recommended that participants avoid test confounders as smoking, use of several drugs, meals, and caffeine-containing liquids before testing for CAN ( 26 ). The participants were advised not to drink caffeine-containing liquids on the day before testing but the other recommendations were not met and may have affected CAN measures ( 4 ).…”

Section: Strengths and Limitationsmentioning

confidence: 99%

“…Distal symmetric polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) are severe and common complications of type 1 diabetes ( 1 , 2 ). DSPN and CAN are usually rare problems during childhood but may be present in adolescents and young adults ( 3 , 4 ). Improved glycemic control in patients with type 1 diabetes may prevent and revert early stages of DSPN and CAN and slow the progression toward overt neuropathy ( 5 – 9 ).…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Glycemic Variability and Diabetic Neuropathy in Young Adults With Type 1 Diabetes

et al. 2020

Self Cite

View full text Add to dashboard Cite

Background: Glycemic variability (GV) may attribute to the pathogenesis of diabetic neuropathy. The aim of this cross-sectional study was to investigate the association between GV and distal symmetric polyneuropathy (DSPN) and cardiovascular autonomic neuropathy (CAN) in a Danish population of young adults with type 1 diabetes. Methods: Young adults between 18 and 24 years with type 1 diabetes were included in this cross-sectional study. CAN was assessed by cardiovascular autonomic reflex tests (CARTs) and heart rate variability (HRV). DSPN was assessed by light pressure, pain and vibration perception, electrochemical skin conductance, sural nerve conduction velocity (SNCV), and amplitude potential (SNAP). GV were obtained by continuous glucose monitoring including coefficient of variation (CV), SD, continuous overall net glycemic action (CONGA), and mean amplitude of glucose excursions (MAGE). Results: The study comprised 133 young adults (43.6% males), mean age of 22 years (SD 1.6). Unadjusted, higher CV was associated with a decreased risk of sural nerve conduction (P = 0.03), abnormal SNAP (P = 0.04) and incidents of definite CAN (P = 0.04). Likewise, higher CONGA was associated with increasing incidents of subclinical DSPN (P = 0.03), abnormal SNAP (P = 0.01), and SNCV (P = 0.02). However, both associations were not statistically significant in the fully adjusted model. Higher MAGE was associated with slightly increasing measures of HRV (P = 0.03) but only when fully adjusted. When correcting for multiple tests significance was lost. A significant association was found between HbA1c and measures of both DSPN (P < 0.02) and HRV (P < 0.03) in fully adjusted models. Conclusions: No significant associations between GV and diabetic neuropathy were found after adjusting for risk factors and multiple tests. This suggests that GV may not be a risk factor for diabetic neuropathy in young adults with type 1 diabetes. However, long-term effects of GV excursions may still play a role in the pathogenic mechanisms leading to neuropathy in later life.

show abstract

“…The results of the prevalence of DSPN and CAN have been discussed elsewhere ( 4 ). In total, 51.1% ( n = 68) were diagnosed with subclinical DSPN.…”

Section: Resultsmentioning

confidence: 99%

“…The study was designed as a cross-sectional observational study. The structure has been described in detail previously (4).…”

Section: Study Populationmentioning

confidence: 99%

Section: Strengths and Limitationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Glycemic Variability and Diabetic Neuropathy in Young Adults With Type 1 Diabetes

et al. 2020

Self Cite

View full text Add to dashboard Cite

show abstract

“…Recent reports from DCCT/EDIC suggests that prevalence of DPN is 28% in T1D patients after 20 years of diabetes (9,15,16). In a Danish study, presence of subclinical DPN was 55.1% whereas only 2.6% individuals were confirmed to have DPN (17). The Pittsburgh Epidemiology of Diabetes Complications Study, suggested that DPN was prevalent in 18% of the 18-29-yearold individuals (18).…”

Section: Introductionmentioning

confidence: 98%

Serum Levels of Inflammatory Proteins Are Associated With Peripheral Neuropathy in a Cross-Sectional Type-1 Diabetes Cohort

Purohit

Tran

et al. 2021

Front. Immunol.

View full text Add to dashboard Cite

Chronic low-grade inflammation is involved in the pathogenesis of type-1 diabetes (T1D) and its complications. In this cross-section study design, we investigated association between serum levels of soluble cytokine receptors with presence of peripheral neuropathy in 694 type-1 diabetes patients. Sex, age, blood pressure, smoking, alcohol intake, HbA1c and lipid profile, presence of DPN (peripheral and autonomic), retinopathy and nephropathy was obtained from patient’s chart. Measurement of soluble cytokine receptors, markers of systemic and vascular inflammation was done using multiplex immunoassays. Serum levels were elevated in in DPN patients, independent of gender, age and duration of diabetes. Crude odds ratios were significantly associated with presence of DPN for 15/22 proteins. The Odds ratio (OR) remained unchanged for sTNFRI (1.72, p=0.00001), sTNFRII (1.45, p=0.0027), sIL2Rα (1.40, p=0.0023), IGFBP6 (1.51, p=0.0032) and CRP (1.47, p=0.0046) after adjusting for confounding variables, HbA1C, hypertension and dyslipidemia. Further we showed risk of DPN is associated with increase in serum levels of sTNFRI (OR=11.2, p<10), sIL2Rα (8.69, p<10-15), sNTFRII (4.8, p<10-8) and MMP2 (4.5, p<10-5). We combined the serum concentration using ridge regression, into a composite score, which can stratify the DPN patients into low, medium and high-risk groups. Our results here show activation of inflammatory pathway in DPN patients, and could be a potential clinical tool to identify T1D patients for therapeutic intervention of anti-inflammatory therapies.

show abstract

The Epidemiology of Diabetic Neuropathy

Hansen

Määttä

Andersen

et al. 2023

Contemporary Diabetes

View full text Add to dashboard Cite

Prevalence of Diabetic Neuropathy in Young Adults with Type 1 Diabetes and the Association with Insulin Pump Therapy

Cited by 16 publications

References 45 publications

Glycemic Variability and Diabetic Neuropathy in Young Adults With Type 1 Diabetes

Glycemic Variability and Diabetic Neuropathy in Young Adults With Type 1 Diabetes

Serum Levels of Inflammatory Proteins Are Associated With Peripheral Neuropathy in a Cross-Sectional Type-1 Diabetes Cohort

The Epidemiology of Diabetic Neuropathy

Contact Info

Product

Resources

About