Prevalence of Diabetic Complications in Relation to Risk Factors

Abstract

The prevalence of diabetic complications is reported from a cross-sectional study of rural diabetic subjects in Western Australia. Logistic-regression analysis has been used to discover potential risk factors associated with each complication. A distinction has been made between time-related variables (age, age at diagnosis, duration of diabetes) and other risk variables. We have attempted to identify the major time-related risk variables for each complication and then examined the effect of other risk variables after accounting for the major time-related variables. The important time-related variables were found to be duration of diabetes for retinopathy, age for macrovascular disease, duration and age at diagnosis of diabetes for sensory neuropathy, and age for renal impairment. When matched on these important time-related variables, the overall prevalences of complications for insulin-dependent (IDDM) compared with non-insulin-dependent (NIDDM) diabetic patients were essentially the same. An exception is renal impairment, for which IDDM patients had a higher prevalence than did NIDDM patients of the same age. After allowing for time-related variables, the analysis also demonstrates positive independent associations between diabetic control (glycosylated hemoglobin) and retinopathy and between diabetic control and macrovascular disease. Plasma cholesterol (positively) and high-density lipoprotein cholesterol (negatively) were related independently to both macrovascular disease and renal impairment. Very few differences in the risk-factor profiles for complications were found for IDDM compared with NIDDM patients after allowing for time-related variables.

Haptoglobin Polymorphism and Association with Complications in Ghanaian Type 2 Diabetic Patients

“…This study was thus conducted to provide data on Hp phenotypes and DM in Ghana with a view to determining whether the various Hp phenotypes have any association with major complications in diabetes. In this study, diabetic patients recorded higher BMI which is consistent with the observation that higher BMI is a major risk factor for the development of DM [39]. A higher BMI recorded for T2DM patients in this study, is consistent with previous reports [40,41].…”

Neurophysiological Changes in Context to Duration of Exposure in Insulin Dependent and Non Insulin Dependent Diabetes Mellitus

“…Our finding is consistent with the previous findings of Vinik, Gregersen, Valensi et al [18][19][20]. Knuiman et al [21] also reported that sensory neuropathy is more common in long standing diabetic subjects especially in those who develop the disease late in life. No significant sensory nerve dysfunction was found in the diabetic group with relatively short duration of diabetes.…”

Hypogonadism and Erectile Dysfunction in Male Patients of Type 2 DM without CAD and With CAD in Indian Scenario

“…Specific indices of dyslipidemia are elevated levels of plasma triglyceride (>150 mg/dl), low levels of HDL-C (<40 mg/dl) and normal LDL-C levels but smaller and denser particles which increase their atherogenic potential 25 the present finding found that cholesterol and triglycerides were elevated in DM2 patients. Also there were a statistically significant differences in triglycerides and HDL-C among DM2 patients and controls (p<0.05).…”