Prevalence of diabetes, impaired fasting glucose and insulin resistance syndrome in an urban Indian population

Gupta, Arvind; Gupta, Rajeev; Sarna, Mukesh; Rastogi, Shweta; Gupta, Vijay; Kothari, Kunal

doi:10.1016/s0168-8227(03)00085-8

Cited by 189 publications

(131 citation statements)

References 18 publications

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“…The overall prevalence of IFG was lower than that reported for the US [26] and higher than the prevalence from an Indian study [27], being in range with recent studies on the population of Iran [28].…”

Section: Discussionsupporting

confidence: 66%

Prevalence of diabetes mellitus in Croatia

Metelko

Pavlić-Renar

Poljičanin

et al. 2008

Diabetes Research and Clinical Practice

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Section: Discussionsupporting

confidence: 66%

Prevalence of diabetes mellitus in Croatia

Metelko

Pavlić-Renar

Poljičanin

et al. 2008

Diabetes Research and Clinical Practice

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“…In this study, SBP and DBP were higher in prediabetes compared with the control individual, which is an indication that they are predisposed to hypertension or prehypertension. This agrees with findings of Gupta and Gupta [26] who showed a significant difference in the same parameter in prediabetics. The possible mechanism is that the activity of angiotensin II is increased in the circulatory system of patients with hypertension.…”

Section: Discussionsupporting

confidence: 93%

“…The possible mechanism is that the activity of angiotensin II is increased in the circulatory system of patients with hypertension. Angiotensin II activates rennin-angiotensin aldosterone system (RAAS) and affects the function of the pancreatic islets, resulting in islet fibrosis and reduced synthesis of insulin and ultimately leading to insulin resistance [26]. The study conducted by Song, et al [27] also showed that increased age, obesity and high fat diet are predisposing factors for prediabetes.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Prediabetes and the Associated Risk of Kidney Disease in Apparently Healthy Subjects in Nnewi, Anambra State, Nigeria

Egbe¹,

Ozomma²,

Meludu³

et al. 2017

Journal of Diseases

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Article HistoryThis study was designed to investigate the prevalence of prediabetes and the associated risk of kidney disease in Nnewi, Nigeria. A total of 277 apparently healthy subjects (73males and 204 females) who were willing to participate were recruited. Anthropometric indices and blood pressure were measured using standard methods while the demographic data and dietary pattern of subjects were obtained using a wellstructured questionnaire. 5mls of blood was collected from eligible subjects (20 prediabetes and 20 non prediabetes ) and dispensed in fluoride oxalate and plain containers for glucose, creatinine (Cr), Urea(Ur), Na+, K+, Cl-, and HCO3-estimation respectively using standard methods. The result showed a prevalence of 7.2% prediabetes in the population. BMI was significantly higher in prediabetes than the control groups (39.4±5.8 vs 29±4.4kg/m2; P>0.05). Again, significant increases in the prediabetic values of FBG (117.54±16.84 vs 83±16.84mg/dl; P>0.05) than the control group were observed. The SBP (128± 11.26 vs 120±2.2mmHg; P>0.05) and DBP (92±4.43 vs 60±5.3mmHg; P>0.05) was also higher in prediabetic groups. Interestingly, result showed no significant difference between the renal parameters in prediabetes and non prediabetes (p>0.05). The study therefore, suggests that the major determinant for predabetes in the study population may be hypertension and obesity whereas kidney function was not impaired.

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“…Insulin resistance was defined in terms of the Homeostasis Model Assessment (HOMA) score (Matthews et al, 1985), HOMA IR ¼ [fasting insulin (mU/ml) Â fasting glucose (mmol/ l)]/22.5 as being indicated by a HOMA IR score greater than the third quartile of the HOMA IR distribution of the nondiabetic population, which was determined, using the nondiabetic patients of the present study as a sample, as 3.99 (Gupta et al, 2003). …”

Section: Methodsmentioning

confidence: 99%

Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin

et al. 2006

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Background: Patients with metabolic syndrome (MS) have above-average risk of developing atherosclerosis and cardiovascular disease. Inflammation plays a key role in the development of atherosclerosis. High levels of the acute phase reactants C-reactive protein (CRP) and ferritin have been reported to correlate with various components of MS. Patients and methods: The serum CRP, ferritin, glucose, insulin, triglycerides, HDL-cholesterol and total cholesterol concentrations of 598 obese or overweight patients were determined, together with relevant anthropometric parameters. Insulin resistance was evaluated by the HOMA method. MS was diagnosed using the ATP III criteria. Results: CRP levels were higher among patients with central obesity than in those without (5.8 vs 3.9 mg/l; P ¼ 0.003), and higher among those with fasting plasma glucose concentrations X110 mg/dl than in those with lower concentrations (7.4 vs 4.1 mg/l; P ¼ 0.01). Serum ferritin levels were higher among patients with triglyceride concentrations X150 mg/dl than in those with lower levels (76.8 vs 40.1 ng/ml; Po0.001), and higher among those with fasting plasma glucose concentrations X110 mg/dl than in those with lower concentrations (75.7 vs 41.7 ng/ml; P ¼ 0.005). The number of MS criteria that were satisfied increased with CRP and ferritin levels. Patients with insulin resistance also had higher CRP and ferritin levels than those without, 7.3 vs 4.3 mg/l for CRP (P ¼ 0.032) and 124.5 vs 80.1 ng/ml for ferritin (Po0.001). Conclusions: MS and insulin resistance are associated with elevated serum CRP and ferritin. Evaluation of subclinical chronic inflammation in patients with MS and/or insulin resistance by determination of these markers might aid in their evaluation as candidates for aggressive intervention against cardiovascular risk factors.

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Prevalence of diabetes, impaired fasting glucose and insulin resistance syndrome in an urban Indian population

Cited by 189 publications

References 18 publications

Prevalence of diabetes mellitus in Croatia

Prevalence of diabetes mellitus in Croatia

Prevalence of Prediabetes and the Associated Risk of Kidney Disease in Apparently Healthy Subjects in Nnewi, Anambra State, Nigeria

Metabolic syndrome, insulin resistance and the inflammation markers C-reactive protein and ferritin

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