Prevalence of cytomegalovirus in nonrheumatic stenotic aortic valves

Radke, Peter W.; Ortlepp, Jan R.; Merkelbach‐Bruse, Sabine; Messmer, Bruno J.; Kaiser, Axel; Kronenberger, Stephan; Handt, Stefan; Hanrath, Peter

doi:10.1016/s0002-9149(01)02277-9

Cited by 5 publications

(2 citation statements)

References 18 publications

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“…On the other hand, the association between infectious agents and calcified aortic valve stenosis (CAS) has been investigated in a limited number of studies (2)(3)(4)(5)(6)(7)(8)(9)(10)(11). For many years, degenerative aortic stenosis was thought to be caused by the passive accumulation of calcium on the surface of the aortic valve leaflet.…”

Section: Introductionmentioning

confidence: 99%

Demonstration of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, and Epstein-Barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction

Bayram¹,

Erdoğan²,

Ekşi³

et al. 2011

Anadolu Kardiyol Derg

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Objective: The aim of this study was to investigate whether bacterial and viral infectious agents can be demonstrated in atherosclerotic lesions of patients with coronary artery disease (CAD) as well as in stenotic aortic and mitral valves from patients undergoing heart valve replacement. Methods: In this cross-sectional study, the presence of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus (CMV), and Epstein-Barr virus (EBV) was investigated by polymerase chain reaction in atherosclerotic and non-atherosclerotic vascular samples taken from patients undergoing coronary artery bypass surgery due to CAD, and from patients undergoing aortic (AVR) and/or mitral valve replacement (MVR) secondary to valvular stenosis. For statistical analyses ANOVA, Chi-square test or Fisher's exact test were used. Results: The presence of C. pneumoniae, M. pneumoniae, and CMV in atherosclerotic versus non-atherosclerotic samples was as follows: 30% vs. 16.7% (p=0.222), 6.7% vs. 3.3% (p=0.554), and 10% vs. 0% (p=0.076), respectively. In valve group, same pathogens were present in AVR and MVR patients as follows: 24.2% vs. 21. 4% (p=0.773), 9.1% vs. 7.1% (p=0.758), and 21.2% vs. 11.9% (p=0.275). EBV DNA was not detected in any of vascular specimens, but in one (3%) patient with AVR (p=0.256). Conclusion: Our results suggest that C. pneumoniae, M. pneumoniae, and CMV are present with similar frequency both in atherosclerotic and non-atherosclerotic vessels. We conclude that although non-atherosclerotic, vascular samples of CAD patients are invaded by infectious agents as like as atherosclerotic vessels. We further conclude that C. pneumoniae, M. pneumoniae, and CMV are present in stenotic aortic and mitral valves and atherosclerotic tissues with similar frequency indicating that atherosclerosis and valvular stenosis might share a common etiology related to infection. (Anadolu Kardiyol Derg 2011; 11: 237-43)

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Section: Introductionmentioning

confidence: 99%

Demonstration of Chlamydophila pneumoniae, Mycoplasma pneumoniae, Cytomegalovirus, and Epstein-Barr virus in atherosclerotic coronary arteries, nonrheumatic calcific aortic and rheumatic stenotic mitral valves by polymerase chain reaction

Bayram¹,

Erdoğan²,

Ekşi³

et al. 2011

Anadolu Kardiyol Derg

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“…Based on the results obtained from the analysis of HCMV-related diseases, no disparities in HCMV seroprevalence or HCMV IgG antibody titres were found between the control and patient groups, as described previously [ 15 , 24 , 25 ]. In the SMI context, we found that male patients presented a significantly lower HCMV seroprevalence when compared to the male control group (HD-2B).…”

Section: Discussionmentioning

confidence: 99%

Spanish HCMV Seroprevalence in the 21st Century

Álvarez-Heredia,

Reina-Alfonso,

Domínguez-del-Castillo

et al. 2023

Viruses

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Human cytomegalovirus (HCMV) is linked to age-related diseases like cardiovascular disease, neurodegenerative conditions, and cancer. It can also cause congenital defects and severe illness in immunocompromised individuals. Accurate HCMV seroprevalence assessment is essential for public health planning and identifying at-risk individuals. This is the first HCMV seroprevalence study conducted in the general Spanish adult population in 30 years. We studied HCMV seroprevalence and HCMV IgG antibody titres in healthy adult donors (HDs) and HCMV-related disease patients from 2010 to 2013 and 2020 to 2023, categorized by sex and age. We compared our data with 1993 and 1999 studies in Spain. The current HCMV seroprevalence among HDs in Spain is 73.48%. In women of childbearing age, HCMV seroprevalence has increased 1.4-fold in the last decade. HCMV-seropositive individuals comprise 89.83% of CVD patients, 69% of SMI patients, and 70.37% of COVID-19 patients. No differences in HCMV seroprevalence or HCMV IgG antibody titres were observed between patients and HDs. A significant reduction in Spanish HCMV seroprevalence among HDs was observed in 1993. However, women of childbearing age have shown an upturn in the last decade that may denote a health risk in newborns and a change in HCMV seroprevalence trends.

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