Effect of aortic valve replacement on c-reactive protein in nonrheumatic aortic stenosis

High levels of high sensitivity C-reactive protein predict the progression of chronic rheumatic mitral stenosis

“…However, several studies [12][13][14]25] have also demonstrated that CRP levels are increased in patients with rheumatic heart diseases and decreased after valve replacement. These data suggest that elevated hs-CRP levels may denote the persistence of inflammation in patients with chronic rheumatic valve diseases in the chronic phase.…”

Degeneration of native and tissue prosthetic valve in aortic position: Do statins play an effective role in prevention?

“…Other factors that may be associated with aortic valve disease include: age [3,4,12,13], male sex [4,11], obesity [12], uremia [26], elevated calcium [27], elevated parathyroid hormone [3,28], osteoporosis [3,4], Paget disease [29], significant renal failure [26,30], elevated homocysteine [31], presence of apolipoprotein E4 allele [32], increase in C reactive protein concentrations [33], presence of matrix metalloproteinases [34][35][36] and presence of cytokine transforming growth factor beta 1 [37].…”

Spectrum of Calcific Aortic Valve Disease

“…[45][46][47][48][49] One study suggested this association was reversible, with a decrease in serum C-reactive protein levels in aortic stenosis patients after valve replacement. 50 However, more recent data are conflicting on the apparent association of inflammatory markers with calcific aortic valve disease. In a recent prospective clinical cohort study of 381 patients, several markers of inflammation, including blood counts, fibrinogen, and Chlamydia pneumoniae seropositivity, were not associated with aortic sclerosis after adjustment for age, gender, and smoking status.…”