Prevalence of corneal diseases in the rural Indian population: the Corneal Opacity Rural Epidemiological (CORE) study

Gupta, Nidhi; Tandon, Radhika; Gupta, Sanjeev Kumar; Dwivedi, Sadanand; Kalaivani, Mani

doi:10.1136/bjophthalmol-2014-305945

Cited by 56 publications

(46 citation statements)

References 13 publications

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“…29,30 Although the aHR in the posterior uveitis subgroup did not show a significant difference, the aHR reached 1.541, which still elevates the risk of developing keratopathies to some degree. On the other hand, there were 406 episodes of keratopathy from 4773 patients in the study group, which has a much higher occurrence rate than the gross Taiwanese population and another Asian population, 4,31 indicating that a majority of the uveitic patients are at risk of developing keratopathy.…”

Section: Discussionmentioning

confidence: 84%

Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study

Nien

Lee

Chao

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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The purpose of this study was to evaluate the effect of uveitis on the development of various keratopathies via the use of the National Health Insurance Research Database (NHIRD) in Taiwan. METHODS. Approximately 1 million patients were randomly sampled from the registry of the NHIRD. Patients diagnosed with uveitis by ophthalmologists were enrolled in the study group after exclusion. Each individual in the study group was age and sex matched to four nonuveitis individuals who serve as the control group. In addition to keratopathy, other possible risk factors and medications were included in the multivariate model, and the effects of different subtypes of uveitis for developing keratopathies were also analyzed. RESULTS. A total of 4773 uveitis patients (2662 male and 2111 female) and 19,092 non-uveitis patients (10,648 male and 8444 female) were enrolled. There were 406 events of keratopathy in the study group, and another 764 events occurred in the control group. A higher incidence rate was found in the study group after adjustment (adjusted hazard ratio [aHR]: 1.772), with a greater cumulative probability (P < 0.0001). For the subgroup analysis, anterior uveitis (aHR ¼ 1.765) and panuveitis (aHR ¼ 3.386) increased the risk of developing keratopathies. Moreover, male sex was associated with a higher aHR than female sex for developing keratopathies in the study group. CONCLUSIONS. The presence of uveitis significantly elevates the risk for developing keratopathy.

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Section: Discussionmentioning

confidence: 84%

Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study

Nien

Lee

Chao

et al. 2018

Invest. Ophthalmol. Vis. Sci.

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“…The CORE study was a cross-sectional, population-based study conducted during July 2011 to January 2013 to determine the prevalence and determinants of corneal diseases in 12 899 participants of all ages, the methodology of which has described previously 5. All adults (≥18 years) detected to have corneal opacity were recruited for determining VR-QoL.…”

Section: Methodsmentioning

confidence: 99%

“…An equal number of healthy controls with no ocular pathology and a visual acuity of 6/6 in both eyes were randomly selected from the study clusters. VI and blindness in the CORE study was defined as per WHO criteria 5 6. As per these criteria, VI was defined as presenting visual acuity <6/18 in the better eye.…”

Section: Methodsmentioning

confidence: 99%

Population-based assessment of vision-related quality of life in corneal disease: results from the CORE study

et al. 2016

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“…1 Corneal transplant is the only effective mode of therapy for visual rehabilitation of people who become blind because of corneal diseases. Success depends on the availability of high-quality donor eyes for corneal transplant.…”

Section: Introductionmentioning

confidence: 99%

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2018

Exp Clin Transplant

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Objectives: Our objective was to assess the awareness of eye donation in an urban slum population and willingness to donate eyes after death. Materials and Methods: A cross-sectional, populationbased study was undertaken in 20 urban slum clusters of the Indian capital, New Delhi. A total of 2004 individuals aged 18 years and older were recruited. After written, informed consent was obtained, knowledge regarding eye donation was assessed through a predesigned close-ended questionnaire. The questionnaire was framed so as to understand the sociodemographic factors influencing the willingness to donate and the awareness of eye donation in this distinct population. Results: The mean age of the recruited individuals was 36.53 ± 13.68 years. Age did not have any significant effect on awareness regarding eye donation. We observed that 34.3% of the study population had no knowledge of eye donation and that 7.78% of the study population had excellent knowledge. Education seemed to be an important determining factor regarding knowledge of eye donation. Multivariable logistic regression demonstrated better awareness among the Hindu population (81.1%) and those belonging to a higher caste (P < .05). The younger age group (those 18-30 years old) showed significant willingness to donate their eyes versus older age groups (P < .001). In our study population, male participants (P = .006), those classified as literate (P < .001), and those classified as Hindu (P < .001) were more willing to pledge their eyes for donation. Conclusions:Although there is substantial awareness about eye donation, willingness to pledge eyes was very low in the urban slum population. Additional efforts are needed to translate this awareness into actual eye donation in the urban poor population. Key words: Corneal transplantation, Cross-sectional study, Questionnaire, Urban poor, Willingness IntroductionCorneal diseases are a major cause of visual impairment and blindness in the developing world. 1 Corneal transplant is the only effective mode of therapy for visual rehabilitation of people who become blind because of corneal diseases. Success depends on the availability of high-quality donor eyes for corneal transplant. Currently, there is a gap between demand and supply of donor corneal tissues in the developing world, where the need is highest due to greater prevalence of corneal diseases in these regions. 2 The lack of a donor cornea pool in developing countries has been directly related to the lack of awareness and willingness to donate among the general population. 3 Various studies have evaluated the awareness among different groups of populations, including medical students, nursing staff, rural populations, and others. [3][4][5][6] Although these studies have suggested many opinions and factors that tend to influence decision-making regarding the subject of "eye donation," no studies have been conducted in populations residing in urban slums, an important segment of the underserved population in India."Urban slums" are unique in their co...

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Prevalence of corneal diseases in the rural Indian population: the Corneal Opacity Rural Epidemiological (CORE) study

Cited by 56 publications

References 13 publications

Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study

Effect of Uveitis on the Development of Keratopathy: A Population-Based Cohort Study

Population-based assessment of vision-related quality of life in corneal disease: results from the CORE study

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