Population-based assessment of vision-related quality of life in corneal disease: results from the CORE study

Vashist, Praveen; Tandon, Radhika; Gupta, Sanjeev Kumar; Dwivedi, Sadanand; Kalaivani, Mani

doi:10.1136/bjophthalmol-2015-307619

Cited by 18 publications

(13 citation statements)

References 11 publications

(8 reference statements)

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“…32,33 Each 5-letter improvement in BCVA corresponded to a 3.2-point improvement in IND-VFQ composite score, a significant change, though thresholds for clinically meaningful change have not been defined in this instrument. This association is comparable to the relationship found between NEI-VFQ scores and BCVA in the Multicenter Uveitis Steroid Treatment (MUST) trial (3.65 points for every line increase in vision, compared to the 3.2 points per line seen in this study).…”

Section: Discussionmentioning

confidence: 99%

Quality-of-Life Outcomes From a Randomized Clinical Trial Comparing Antimetabolites for Intermediate, Posterior, and Panuveitis

Niemeyer

Gonzales

Rathinam

et al. 2017

American Journal of Ophthalmology

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Purpose To evaluate the changes in quality of life in noninfectious uveitis patients treated with two of the most commonly prescribed antimetabolite treatments. Design Secondary analysis of a multicenter, block-randomized, clinical trial (ClinicalTrials.gov NCT01232920). Methods Eighty patients at Aravind Eye Hospitals in Madurai and Coimbatore, India, with noninfectious intermediate, posterior, or panuveitis were randomized to receive oral methotrexate, 25 mg weekly, or oral mycophenolate mofetil, 1 g twice daily, and were followed up monthly for 6 months. Best-corrected visual acuity, IND-VFQ, and SF-36 were obtained at enrollment and at 6 months (or prior in the event of early treatment failure). Results IND-VFQ scores, on average, increased by 9.2 points from trial enrollment to 6 months (95% CI: 4.9, 13.5, P =0.0001). While the SF-36 physical component summary score did not significantly differ over the course of the trial, the mental component summary score decreased by 2.3 points (95% CI: −4.4, −0.1, P=0.04) and the vitality subscale decreased by 3.5 points (95% CI: −5.6, −1.4, P=0.001). Quality of life scores did not differ between treatment arms. Linear regression modeling showed a 3.2 point improvement in IND-VFQ score for every 5 letter improvement in visual acuity (95% CI: 1.9, 4.3; P<0.001). Conclusions Although uveitis treatment was associated with increased vision and vision-related quality of life, patient-reported physical health did not change after 6 months of treatment, and, mental health decreased. Despite improved visual outcomes, uveitis patients receiving systemic immunosuppressive therapy may experience a deterioration in mental health-related quality of life.

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Section: Discussionmentioning

confidence: 99%

Quality-of-Life Outcomes From a Randomized Clinical Trial Comparing Antimetabolites for Intermediate, Posterior, and Panuveitis

Niemeyer

Gonzales

Rathinam

et al. 2017

American Journal of Ophthalmology

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“…14 Similarly, Vashist et al also found higher visual function scores in persons with VI than persons without VI in all three domains. 22 Chiang et al also found worse vision functioning scores among those with visual impairment in their study done with visual function index-11 questionnaire. 23 The IND-VFQ-33 scores were also compared across the sociodemographic variables.…”

Section: Discussionmentioning

confidence: 87%

Prevalence of visual impairment and associated vision related quality of life among older adults in an urbanized village in Delhi

Praveena

Kumar

Barik

et al. 2020

Int J Community Med Public Health

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Background: Vision impairment (VI) is a public health problem, of which the greatest burden is shared by older adults. This study was done to find out the prevalence of VI among older adults and its association with sociodemographic variables and vision related quality of life.Methods: This cross-sectional study was done in an urbanized village in east Delhi from May to December 2019. 224 participants were selected by house to house visit by simple random sampling. A pre-tested, semi-structured tool was used to collect information regarding socio-demography. Visual acuity was measured by Snellen’s chart. Vision-related quality of life was assessed using Indian Vision function questionnaire-33 (IND-VFQ-33) in all three domains.Results: About 20.1% of participants were found having VI. It was found more among those who were not working {age adjusted odds ratio (AOR)=22.3, 95% confidence interval (CI)=3.2-152.2}, and those who were past chewer (AOR=5.54, 95% CI=1.75-17.4). The mean total visual function score was found 108.40 (5.10) among visually impaired participants. The mean and median of these scores were found higher among participants with VI.Conclusions: One out of every 5 older adults are suffering from VI. It affects quality of life significantly. Early screening, counselling and timely referral along with accessible and affordable quality eye care service should be promoted.

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“…A population-based corneal opacity rural epidemiological[24] study was done to assess vision related quality of life (VR QoL) in rural North Indian population. VR QoL was impaired in patients with corneal disease more so in those with corneal blindness.…”

Section: Resultsmentioning

confidence: 99%

Upgradation and modernization of eye banking services: Integrating tradition with innovative policies and current best practices

Tandon

Singh

Gupta

et al. 2017

Indian J Ophthalmol

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Purpose:The purpose of this study is to review the history and evolution of the National Eye Bank (NEB) and analyze the impact over the years and report the outcome of the invested resources.Methods:Review of archival material, records, project reports, policy and procedures' manuals, and publications was done. Descriptive and analytical processing of data obtained was undertaken. Parameters evaluated included total collection, transplantation, utilization rates of donor cornea, changing trends over time in terms of numbers and duration of recipients waiting, impactful research translated into changes in standard operating protocols, new facilities, and subsequent effects on numbers or quality assurance measures and overview of major achievements. Periodic situational analysis with contextual relevance and interpretation of outcomes was done pertaining to national goals and international standards.Results:The NEB and cornea services have played a key leadership role in furthering the development of eye banking and corneal transplantation services. The contribution extends beyond routine patient care to education, training, generation of resources, advocacy, and policymaking. In quantifiable terms, the overall performance has steadily increased over the years. Major contributions include training of doctors, eye bank staff and corneal surgeons, introduction of innovative techniques for corneal transplantation, setting of national standards for eye banking and provision of preservation media, customized corneal, and ocular surface cell replacement therapy in collaboration with other departments and institutes.Conclusion:The eye banking and corneal transplantation facilities have evolved with time providing quality services, modernized as appropriate with updated knowledge and incorporating technological advances supported by the systematic evidence-based approach.

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Population-based assessment of vision-related quality of life in corneal disease: results from the CORE study

Abstract: VR-QoL is impaired in patients with corneal disease, more so in patients with corneal blindness. This is the first population-based study to document VR-QoL through IND-VFQ-33 in the Indian population with corneal disease.

Cited by 18 publications

References 11 publications

Quality-of-Life Outcomes From a Randomized Clinical Trial Comparing Antimetabolites for Intermediate, Posterior, and Panuveitis

Quality-of-Life Outcomes From a Randomized Clinical Trial Comparing Antimetabolites for Intermediate, Posterior, and Panuveitis

Prevalence of visual impairment and associated vision related quality of life among older adults in an urbanized village in Delhi

Upgradation and modernization of eye banking services: Integrating tradition with innovative policies and current best practices

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