Prevalence of COPD in Women Compared to Men Around the Time of Diagnosis of Primary Lung Cancer

Loganathan, Raghu; Stover, Diane E.; Shi, Wei; Venkatraman, Ennapadam

doi:10.1378/chest.129.5.1305

Cited by 180 publications

(173 citation statements)

References 27 publications

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“…A number of studies have reported the results of their spirometry in newly diagnosed lung cancer [3,4]. Although these studies use different spirometric criteria, they show that approximately 40-70% of lung cancer cases have coexisting COPD.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, smoking-induced airway inflammation typically persists in those smokers with COPD for many years after quitting smoking [33]. This persistent inflammation may, in part, explain why ,50% of lung cancer cases are found in ex-smokers [3,10,19]. We propose that susceptibility to lung cancer and COPD results from overlapping or shared genetic effects [7-10, 13, 14], most likely expressed through smokinginduced inflammation.…”

Section: Thoracic Oncology Rp Young Et Almentioning

confidence: 99%

“…Age, smoking history, family history and impaired lung function have been identified as key risk factors [2]. The question that then arises is: does the association between chronic obstructive pulmonary disease (COPD) and lung cancer come down to more than a shared smoking history?Cross-sectional studies show that the prevalence of COPD is 40-70% of those diagnosed with lung cancer [3,4], although prevalence is highly dependent on diagnostic criteria, age, sex and smoking exposure [5]. As none of these studies compared the prevalence of COPD in their lung cancer cohorts with a smoking cohort matched for these variables, the significance of this finding is uncertain.…”

mentioning

confidence: 99%

“…Cross-sectional studies show that the prevalence of COPD is 40-70% of those diagnosed with lung cancer [3,4], although prevalence is highly dependent on diagnostic criteria, age, sex and smoking exposure [5]. As none of these studies compared the prevalence of COPD in their lung cancer cohorts with a smoking cohort matched for these variables, the significance of this finding is uncertain.…”

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confidence: 99%

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COPD prevalence is increased in lung cancer, independent of age, sex and smoking history

Young¹,

Hopkins²,

Christmas³

et al. 2009

Eur Respir J

577

493

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Chronic obstructive pulmonary disease (COPD) is a common comorbid disease in lung cancer, estimated to affect 40-70% of lung cancer patients, depending on diagnostic criteria. As smoking exposure is found in 85-90% of those diagnosed with either COPD or lung cancer, coexisting disease could merely reflect a shared smoking exposure. Potential confounding by age, sex and pack-yr smoking history, and/or by the possible effects of lung cancer on spirometry, may result in over-diagnosis of COPD prevalence.In the present study, the prevalence of COPD (pre-bronchodilator Global Initiative for Chronic Obstructive Lung Disease 2+ criteria) in patients diagnosed with lung cancer was 50% compared with 8% in a randomly recruited community control group, matched for age, sex and pack-yr smoking exposure (n5602, odds ratio 11.6; p,0.0001).In a subgroup analysis of those with lung cancer and lung function measured prior to the diagnosis of lung cancer (n5127), we found a nonsignificant increase in COPD prevalence following diagnosis (56-61%; p50.45). After controlling for important variables, the prevalence of COPD in newly diagnosed lung cancer cases was six-fold greater than in matched smokers; this is much greater than previously reported.We conclude that COPD is both a common and important independent risk factor for lung cancer.KEYWORDS: Chronic obstructive pulmonary disease, epidemiology, lung cancer, risk, spirometry A s only 10-15% of chronic smokers get lung cancer [1], host susceptibility factors have been implicated. Age, smoking history, family history and impaired lung function have been identified as key risk factors [2]. The question that then arises is: does the association between chronic obstructive pulmonary disease (COPD) and lung cancer come down to more than a shared smoking history?Cross-sectional studies show that the prevalence of COPD is 40-70% of those diagnosed with lung cancer [3,4], although prevalence is highly dependent on diagnostic criteria, age, sex and smoking exposure [5]. As none of these studies compared the prevalence of COPD in their lung cancer cohorts with a smoking cohort matched for these variables, the significance of this finding is uncertain. Moreover, none of these studies considered that lung cancer may itself cause an obstructive effect on spirometry. It is possible that potential confounding by age, sex and packyr smoking history on COPD prevalence, and/or the possible effects of lung cancer per se on spirometry, could result in over-diagnosis of COPD and a falsely increased association between COPD and lung cancer.

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Section: Discussionmentioning

confidence: 99%

Section: Thoracic Oncology Rp Young Et Almentioning

confidence: 99%

mentioning

confidence: 99%

mentioning

confidence: 99%

See 2 more Smart Citations

COPD prevalence is increased in lung cancer, independent of age, sex and smoking history

Young¹,

Hopkins²,

Christmas³

et al. 2009

Eur Respir J

577

493

View full text Add to dashboard Cite

show abstract

“…Another crucial aspect is the frequent relationship between NSCLC and COPD: in an epidemiological study [20], COPD occurs in 73% of men and 53% of women with NSCLC. Recent studies also show that physical performance is an independent predictor of survival in NSCLC patients [21][22][23], currently the same goes for depression and anxiety which usually accompanies the disease [24].…”

Section: Introductionmentioning

confidence: 99%

Pulmonary Rehabilitation in lung cancer

Pasqua

Geraneo

Nardi

et al. 2015

Monaldi Arch Chest Dis

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Non-small-cell lung cancer (NSCLC) represents a very severe disease, being its incidence increasingly reported and, nowadays, successfully treatable only when surgery is deemed to be feasible. Furthermore, the disease and the clinical effects related to the complementary therapies (radio and/or chemotherapy) may strongly affect, frequently with dramatic clinical side effects, the patient’s ability to endure physical exercise. In such context, the PR(PR), which has already been proved to be useful and effective in other diseases such as COPD, could play a pivotal role. The aim of this review article is, therefore, to analyze the pertinent data recently reported in English literature in order to highlight the role of rehabilitation as complementary therapy in the management of patients with NSCLC. The evidence currently available suggests that, when surgery is indicated, PR is a safe and feasible option, both during pre-operative and post-operative timing.The safety and feasibility of rehabilitation are proven even in inoperable patients, although to date, little evidence has been reported on its role in the overall management of such complex diseases.

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High expression of SPP1 in patients with chronic obstructive pulmonary disease (COPD) is correlated with increased risk of lung cancer

Miao

Xiao

et al. 2021

FEBS Open Bio

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Chronic obstructive pulmonary disease (COPD) is characterized by persistent airway inflammation and fixed airflow obstruction. Patients with COPD have increased risk of lung cancer (LC), and the coexistence of both diseases is associated with poorer survival. However, the mechanisms predisposing patients with COPD to LC development and poor prognosis remain unclear. Gene expression profiles were downloaded from the Gene Expression Omnibus. Twenty-two data sets were included (n = 876). We identified 133 DEGs and 145 DEGs in patients with COPD and LC compared with healthy controls, respectively. There were 1544 DEGs in patients with LC and coexisting COPD compared with COPD, and these DEGs are mainly involved in the cell cycle, DNA replication, p53 signalling and insulin signalling. The biological processes primarily associated with these DEGs are oxidation reduction and apoptosis. SPP1 was the only overlapping DEG that was up-regulated in patients with COPD and/or LC, and this was validated by qPCR in an independent cohort. The area under the curve value for SPP1 was 0.893 (0.822-0.963) for the prediction of LC in patients with COPD. High expression of SPP1 in patients with LC was associated with shorter survival time. Up-regulation of SPP1 may be associated with increased risk of LC in patients with COPD and therefore may have potential as a therapeutic target for LC in patients with COPD.Chronic obstructive pulmonary disease (COPD) and lung cancer (LC) are leading cause of morbidity and mortality worldwide. COPD is characterized by persistent airway inflammation and fixed airflow obstruction [1]. The overall prevalence of spirometry-defined COPD is 8.6% among the general population aged 20 years or older, accounting for 99.9 million people with COPD in China [2]. It is currently the third leading cause of death worldwide and imposes huge economic burden on patients [3]. LC is the number one cause of cancer deaths worldwide with a low 5-year overall survival rate [4,5]. A previous study has

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Prevalence of COPD in Women Compared to Men Around the Time of Diagnosis of Primary Lung Cancer

Cited by 180 publications

References 27 publications

COPD prevalence is increased in lung cancer, independent of age, sex and smoking history

COPD prevalence is increased in lung cancer, independent of age, sex and smoking history

Pulmonary Rehabilitation in lung cancer

High expression of SPP1 in patients with chronic obstructive pulmonary disease (COPD) is correlated with increased risk of lung cancer

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