Prevalence of Cognitive Impairment without Dementia in the United States

Plassman, Brenda L.; Langa, Kenneth M.; Fisher, Gwenith G.; Heeringa, Steven G.; Weir, David R.; Ofstedal, Mary Beth; Burke, James R.; Hurd, Michael D.; Potter, Guy G.; Rodgers, Willard L.; Steffens, David C.; McArdle, John J.; Willis, Robert J.; Wallace, Robert B.

doi:10.7326/0003-4819-148-6-200803180-00005

Cited by 794 publications

(651 citation statements)

References 45 publications

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“…Over 13% of adults over 71 y old have some quantifiable dementia (14), and 22.2% suffer from serious cognitive decline (15). Of course, aging takes various forms, and many older adults have motor or sensory changes but are not necessarily cognitively impaired, whereas others experience healthy aging.…”

mentioning

confidence: 99%

Like cognitive function, decision making across the life span shows profound age-related changes

Tymula

Belmaker²,

Ruderman³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

242

269

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Significance Although largely unstudied, behavioral changes in decision making across the life span have implications for problems associated with poor decision making at different life stages, such as careless driving in adolescents and disadvantageous medical or financial decision making in older adults. We examine age-based differences in individual decision-making characteristics—choice consistency, rationality, and preferences for known and unknown risks—in 12- to 90-y-olds. We found that even the healthiest of elders show profoundly compromised decision making, and that risk attitudes show systematic changes across the life span that have important policy implications.

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mentioning

confidence: 99%

Like cognitive function, decision making across the life span shows profound age-related changes

Tymula

Belmaker²,

Ruderman³

et al. 2013

Proc. Natl. Acad. Sci. U.S.A.

242

269

View full text Add to dashboard Cite

show abstract

“…The high prevalence of cognitive impairment with advancing age (Plassman et al, 2008), together with rapid demographic ageing, underlines the importance of developing interventions to improve or maintain cognitive function in later life.…”

Section: Introductionmentioning

confidence: 99%

The impact of cognitive training and mental stimulation on cognitive and everyday functioning of healthy older adults: A systematic review and meta-analysis

Kelly

Loughrey

Lawlor

et al. 2014

Ageing Research Reviews

383

285

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“…[1,2] Critical to translating new therapies into improved patient care is the development of costeffective panels of biomeasures that complement cognitive testing, clinical examination, and neuroimaging. Serum albumin is of interest as it is the most abundant protein in human plasma, a marker of liver function, a negative acute-phase marker, and a key antioxidant [3][4][5] Findings from highly selected clinical samples suggest serum albumin concentration may be associated with cognitive impairment and dementia.…”

Section: Introductionmentioning

confidence: 99%

Serum Albumin Concentration and Cognitive Impairment

Llewellyn¹

2009

CAR

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Results from clinical samples suggest low serum albumin may be associated with cognitive impairment, though evidence from population-based studies is inconclusive. Participants were 1,752 adults (699 men and 1,053 women) aged 65 years and over from the Health Survey for England 2000, a nationally representative population-based study. Cognitive impairment was assessed using the Abbreviated Mental Test Score. The cross-sectional relation of serum albumin quartiles to cognitive impairment was modelled using logistic regression. Two hundred and twelve participants were cognitively impaired (68 men and 144 women). Odds ratios (95% confidence intervals) for cognitive impairment in the first (2.2-3.8 g/dl), second (3.9-4.0 g/dl), and third (4.1-4.3 g/dl) quartiles of serum albumin compared with the fourth (4.4-5.3 g/dl) were 2.5 (1.3-5.1), 1.7 (0.9-3.5), and 1.5 (0.7-2.9), after adjustment for age, sex, education and additional risk factors for cognitive impairment (p for linear trend = 0.002). A highly similar pattern of associations was observed for men and women. Our data provide new evidence to suggest that low serum albumin is independently associated with increased odds of cognitive impairment in the elderly population.

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Prevalence of Cognitive Impairment without Dementia in the United States

Abstract: Cognitive impairment without dementia is more prevalent in the United States than dementia, and its subtypes vary in prevalence and outcomes.

Cited by 794 publications

References 45 publications

Like cognitive function, decision making across the life span shows profound age-related changes

Like cognitive function, decision making across the life span shows profound age-related changes

The impact of cognitive training and mental stimulation on cognitive and everyday functioning of healthy older adults: A systematic review and meta-analysis

Serum Albumin Concentration and Cognitive Impairment

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