Objective: To clarify work location's association with musculoskeletal symptoms. Methods: Study 1 surveyed 246 working adults who usually felt pain, in general, and increased pain from computer work. Study 2 surveyed a nationally representative sample of 1084 working adults. Results: In study 1, 32.5% of the participants sought treatment for their increased pain from computer work. Education differed by work location. When education was considered, there were no significant work location differences in pain intensity, pain interference, or self-rated health. In study 2, COVID-19 diagnoses, education, and gender differed by work location. Age and work location explained self-rated health. Self-rated health was associated with musculoskeletal ache. Work location did not significantly predict musculoskeletal ache. Conclusion: Working at home was associated with fewer COVID-19 diagnoses and higher self-rated health than working at employers' locations.