Background:Chronic kidney disease (CKD) is a major public health problem worldwide. Prevalence and associated risk factors of CKD was evaluated in the greater Mashhad, a highly populated pilgrimage city, in 2018 on 2,976 subjects.
Methods:This study was carried out in the greater Mashhad, a highly populated pilgrimage city, in 2018 on 2,976 subjects. For each participant a standard questionnaire, a physical examination and clinical history were completed. Then biochemical and hematologic tests for kidney function were performed.
Results:Obesity was observed more frequently in subjects with CKD, thus BMI was positively correlated with the prevalence of CKD (p<0.001). Moderately reduced GFR was found in 17.6% and 7.1%, and severely reduce GFR at 0.7% and 0.5%, of males and females, respectively (p<0.001).Drug abuse also showed a strong association with CKD (p=0.004), but smoking did not. Using univariate and multivariate logistic regression of decreased estimated GFR<60 showed that age (OR=1.06), gender (OR=2.14), diabetes (OR=1.07), hypertension (OR=1.39) and drug usage (OR=3.29) were risk factors for CKD; BMI was not. The same statistics showed that only age (OR=1.02), diabetes (OR=2.61) and hypertension (OR=1.16) were risk factors for albuminuria. The prevalence of hypertension (22.1%) was a risk factor for CKD, and vice versa. BMI and drug abuse were also risk factors for hypertension, but not smoking.
Conclusion:These findings demonstrated that progression of CKD and hypertension in any population should be considered in the context of changes in human behaviours, etiology, disease severity, co-occurring diseases, addiction and priority of therapy over prevention.