Prevalence of chronic kidney disease and metabolic related indicators in Mianzhu, Sichuan, China

Chen, Feng; Wang, Miao; Jiang, Yan

doi:10.3389/fpubh.2023.1252110

Cited by 2 publications

(1 citation statement)

References 40 publications

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“…End-stage renal disease (ESRD) is the most severe chronic kidney disease (CKD) stage and has become a signi cant global health problem [6]. 10.8% of Chinese people have CKD, and the prevalence of ESRD is rising each year [7]. Because it increases survival and improves patient quality of life, renal transplantation is acknowledged as the most successful therapy in clinical ESRD treatment [8,9].…”

Section: Introductionmentioning

confidence: 99%

Association between End-stage renal disease and the polymorphism of HLA in Guangxi Zhuang population

Pei,

Li,

Huang

et al. 2024

Preprint

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Objective: To investigate the genetic relationship between end-stage renal disease (ESRD) and the Guangxi Zhuang population's human leukocyte antigen (HLA) allele. Methods: To perform the polymerase chain reaction reversed sequence-specific oligonucleotide (PCR-rSSO)method, genotyping for 325 patients with ESRD at the HLA-A, B, C, DRB1, and DQB1 loci was done. The direct counting method was used to determine the HLA alleles' frequencies, and Arlequin software(3.5.2.2) was used for haplotypic frequency analyses, compared with 350 healthy donors of Guangxi Zhuang nationality. Results: We found that only HLA-DRB1*14:54 showed a positive association with ESRD (P=0.005, Pc=0.035, OR=1.484, CI=1.122-1.963) after Bonferroni correction, so that it may be a protective allele for ESRD. A*11:01-B*15:02-DRB1*15:01 and A*11:01-C*08:01-B*15:02-DRB1*12:02-DQB1*03:01 were more prevalent in ESRD after Bonferroni correction. Conclusion: ESRD patients and the healthy population in Guangxi Zhuang have high HLA-A, B, C, DRB1, and DQB1 allele and haplotype frequencies. DRB1*14:54, A*11:01-B*15:02-DRB1*15:01, and A*11:01-C*08:01-B*15:02-DRB1*12:02-DQB1*03:01 were potentially valuable allele and haplotypes for evaluating the risk of ESRD in Guangxi Zhuang population.

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Section: Introductionmentioning

confidence: 99%

Association between End-stage renal disease and the polymorphism of HLA in Guangxi Zhuang population

Pei,

Li,

Huang

et al. 2024

Preprint

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Persistent albuminuria and chronic kidney disease in adults with sickle cell anaemia: Results from a multicenter natural history study

Zhou,

Derebail,

Desai

et al. 2024

Br J Haematol

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SummaryClinical and laboratory correlates of chronic kidney disease (CKD) in sickle cell anaemia remain incompletely defined. In a multicenter cohort study, we evaluated the prevalence of persistent albuminuria (PA) and characteristics associated with PA, albumin–creatinine ratio (ACR) and decreased estimated glomerular filtration rate (eGFR) using logistic, linear and multinomial regression models, respectively. Of 269 participants (median age: 30 years; 57.2% females), the prevalence of PA was 35.7%. Using baseline ACR values of <100 and ≥100 mg/g, the probabilities of PA were 30.0% and 94.6%, respectively. In multivariable logistic regression analyses, male sex (β = 0.80 [SE = 0.36], p = 0.024) and ACE inhibitors/ARBs use (β = 1.54 [SE = 0.43], p < 0.001) were associated with higher likelihoods of PA, while higher haemoglobin (β = −0.33 [SE = 0.13], p = 0.009) and HbF (β = −0.04 [SE = 0.02], p = 0.041) were associated with lower likelihoods of PA. In multivariable multinomial regression analyses, older age (β = 0.06 [SE = 0.02], p = 0.004) and higher alkaline phosphatase (β = 0.01 [SE = 0.00], p = 0.004) were associated with higher odds of having eGFR 60–90 versus eGFR>90 mL/min/1.73 m2 using the cystatin C‐based CKD‐EPI‐2012 equation. Additionally, higher systolic blood pressure (β = 0.11 [SE = 0.03], p = 0.001) and blood urea nitrogen (β = 0.45 [SE = 0.12], p < 0.001) were associated with higher odds, while higher haemoglobin (β = −1.22 [SE = 0.43], p = 0.004) was associated with lower odds of having eGFR<60 versus eGFR>90 mL/min/1.73 m2. PA and decreased eGFR are associated with measures of disease severity and comorbid conditions (Clinicaltrials.gov Identifier: NCT03277547).

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Prevalence of chronic kidney disease and metabolic related indicators in Mianzhu, Sichuan, China

Cited by 2 publications

References 40 publications

Association between End-stage renal disease and the polymorphism of HLA in Guangxi Zhuang population

Association between End-stage renal disease and the polymorphism of HLA in Guangxi Zhuang population

Persistent albuminuria and chronic kidney disease in adults with sickle cell anaemia: Results from a multicenter natural history study

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