Prevalence of cerebrovascular lesions in patients with Lewy body dementia: A neuropathological study

Reuck, Jacques De; Deramecourt, Vincent; Cordonnier, Charlotte; Leys, Didier; Pasquier, Florence; Maurage, Claude‐Alain

doi:10.1016/j.clineuro.2012.11.005

Cited by 31 publications

(30 citation statements)

References 21 publications

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“…These findings are in contrast to the high incidence of small bleeds observed in brains of patients with Alzheimer dementia (AD) and Lewy body dementia (LBD) [4,5,9].…”

Section: Introductioncontrasting

confidence: 52%

“…This is similar to what happens in frontotemporal lobar degeneration, which in most cases also belongs to the family of tauopathies [7] and is in contrast to the overall prevalence of small bleeds in AD and in the cerebral cortex of LBD [4,5,9]. However, compared to age-matched controls, an increased number of mini-bleeds is observed around the dentate nucleus of the cerebellum and in the tegmentum pontis of PSP brains.…”

Section: Discussionmentioning

confidence: 51%

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Original article Prevalence of small cerebral bleeds in patients with progressive supranuclear palsy: a neuropathological study with 7.0-Tesla magnetic resonance imaging correlates

Reuck¹,

Caparros-Lefebvre²,

Deramecourt³

et al. 2014

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“…These findings are in contrast to the high incidence of small bleeds observed in brains of patients with Alzheimer dementia (AD) and Lewy body dementia (LBD) [4,5,9].…”

Section: Introductioncontrasting

confidence: 52%

Section: Discussionmentioning

confidence: 51%

Original article Prevalence of small cerebral bleeds in patients with progressive supranuclear palsy: a neuropathological study with 7.0-Tesla magnetic resonance imaging correlates

Reuck¹,

Caparros-Lefebvre²,

Deramecourt³

et al. 2014

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“…27 In the present MRI study, no significant WMCs are observed in LBD although previously shown to be moderately present on neuropathologic examination. 28 LBD pathology is considered inversely correlated to the severity of atherosclerosis, infarcts and small-vessel disease. 29 Although severe WMCs are described on neuropathologic examination 30 and on MRI 31,32 in PSP brains, we are not able to demonstrate a statistical difference compared to controls.…”

Section: Discussionmentioning

confidence: 99%

Topographic distribution of white matter changes and lacunar infarcts in neurodegenerative and vascular dementia syndromes: A post-mortem 7.0-tesla magnetic resonance imaging study

Reuck

Auger

Durieux

et al. 2016

European Stroke Journal

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Background: White matter changes and lacunar infarcts are regarded as linked to the same underlying small-vessel pathology. On magnetic resonance imaging, white matter changes are frequently observed, while the number of lacunar infarcts is probably underestimated. The present study post-mortem 7.0-tesla magnetic resonance imaging study compares the severity and the distribution of white matter changes and lacunar infarcts in different neurodegenerative and vascular dementia syndromes in order to determine their impact on the disease evolution. Patients and methods: Eighty-four post-mortem brains consisting of 15 patients with pure Alzheimer's disease and 12 with associated cerebral amyloid angiopathy, 14 patients with frontotemporal lobar degeneration, 7 with Lewy body dementia, 10 with progressive supranuclear palsy, 14 with vascular dementia and 12 control brains were examined. Six hemispheric coronal sections of each brain underwent 7.0-tesla magnetic resonance imaging. Location and severity of white matter changes and lacunar infarcts were evaluated semi-quantitatively in each section separately. Results: White matter changes predominated in the prefrontal and frontal sections of frontotemporal lobar degeneration and in the post-central section of associated cerebral amyloid angiopathy brains, while overall increased in vascular dementia cases. Lacunar infarcts were more frequent in the vascular dementia brains and mainly increased in the centrum semiovale. Conclusions: White matter changes have a different topographic distribution in neurodegenerative diseases and are most severe and extended in vascular dementia. Lacunar infarcts predominate in the deep white matter of vascular dementia compared to the neurodegenerative diseases. Vascular cognitive impairment is mainly linked to white matter changes due to chronic ischaemia as well as to lacunar infarcts due to small-vessel occlusion.

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“…142 Additional analyses by the same group revealed the prevalence and severity of cerebrovascular lesions in post-mortem brains of patients with DLB as compared with age-matched controls. 14 The authors concluded that these histopathologic changes reflect the neurodegenerative process, which is associated with BBB injury. 14 Increased BBB permeability reported in VaD patients corresponds to a higher mean albumin ratio (CSF/serum) as compared with healthy controls.…”

Section: Blood-brain Barrier Dysfunctionmentioning

confidence: 99%

The neuropathology and cerebrovascular mechanisms of dementia

Raz

Knoefel

Bhaskar

2015

J Cereb Blood Flow Metab

350

284

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The prevalence of dementia is increasing in our aging population at an alarming rate. Because of the heterogeneity of clinical presentation and complexity of disease neuropathology, dementia classifications remain controversial. Recently, the National Plan to address Alzheimer's Disease prioritized Alzheimer's disease-related dementias to include: Alzheimer's disease, dementia with Lewy bodies, frontotemporal dementia, vascular dementia, and mixed dementias. While each of these dementing conditions has their unique pathologic signature, one common etiology shared among all these conditions is cerebrovascular dysfunction at some point during the disease process. The goal of this comprehensive review is to summarize the current findings in the field and address the important contributions of cerebrovascular, physiologic, and cellular alterations to cognitive impairment in these human dementias. Specifically, evidence will be presented in support of small-vessel disease as an underlying neuropathologic hallmark of various dementias, while controversial findings will also be highlighted. Finally, the molecular mechanisms shared among all dementia types including hypoxia, oxidative stress, mitochondrial bioenergetics, neuroinflammation, neurodegeneration, and bloodbrain barrier permeability responsible for disease etiology and progression will be discussed.

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Prevalence of cerebrovascular lesions in patients with Lewy body dementia: A neuropathological study

Cited by 31 publications

References 21 publications

Original article Prevalence of small cerebral bleeds in patients with progressive supranuclear palsy: a neuropathological study with 7.0-Tesla magnetic resonance imaging correlates

Original article Prevalence of small cerebral bleeds in patients with progressive supranuclear palsy: a neuropathological study with 7.0-Tesla magnetic resonance imaging correlates

Topographic distribution of white matter changes and lacunar infarcts in neurodegenerative and vascular dementia syndromes: A post-mortem 7.0-tesla magnetic resonance imaging study

The neuropathology and cerebrovascular mechanisms of dementia

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