Prevalence of breast cancer sub-types by immunohistochemistry in patients in the Regional General Hospital 72, Instituto Mexicano del Seguro Social

Pérez-Rodríguez, Gabriel

doi:10.1016/j.circen.2015.09.017

Cited by 8 publications

(5 citation statements)

References 18 publications

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“…The median age of the patients included in our study was 70 years (mean age 69.3±15.19 years). This result differs from other studies, in which the mean age of the patients has been reported to be 53 years, 53.3 years, 57.5 years, and 48.5 years (21)(22)(23)(24). These variations might result from the diverse age range of women examined in these studies.…”

Section: Discussioncontrasting

confidence: 94%

Clinical, Histopathological, and Immunohistochemical Characteristics of Predictive Biomarkers of Breast Cancer: A Retrospective Study

PAPALEXIS,

GEORGAKOPOULOU,

KERAMYDAS

et al. 2024

CDP

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Background/Aim: Breast cancer is a complex disease with variability in clinical manifestation, response to current therapy, and biochemical and histological features among various subgroups. Histologic grading and immuno-histochemical evaluation of estrogen receptor (ER), progesterone receptor (PR), human epidermal growth factor receptor 2 (HER-2), and Ki-67 proliferation index play a crucial role in increasing the differential diagnostic value among various types of breast carcinoma. The aim of this study was to determine the histopathological and immuno-histochemical characteristics of breast tumors from a University Laboratory of Pathology in Greece. Patients and Methods: The study included female patients over 18 years of age, whose histopathological and immunohistochemical reports were stored in the archives of the First Department of Pathology of National and Kapodistrian University of Athens. The study involved 197 female patients with a median age of 70 years and median tumor size of 2.6 cm. Results: Most tumors were located at the left breast and ductal carcinoma was the most common histologic type (35.5%). Most tumors had histologic grade 2 (106, 53.8%), and were classified as TNM stage IIA (65, 33%). Most grade 1 and 2 tumors exhibited high expression of PR, whereas most grade 3 tumors had no PR expression. Moreover, patients with triple-negative cancer presented with grades 2 and 3 at a lower percentage compared to patients without a triple-negative phenotype (p=0.001). Conclusion: The study provided valuable insights into the histopathological and immuno-histochemical characteristics involved in the development and progression of breast cancer.

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Section: Discussioncontrasting

confidence: 94%

Clinical, Histopathological, and Immunohistochemical Characteristics of Predictive Biomarkers of Breast Cancer: A Retrospective Study

PAPALEXIS,

GEORGAKOPOULOU,

KERAMYDAS

et al. 2024

CDP

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“…Most frequently, breast cancer cases with the malignant process localized in the upper outer quadrant of the mammary gland were reported by 44.6% of those who were brought to the pharmacy (C50.4 according to ICD-10). These findings are in line with findings from previous studies, including one conducted in Saudi Arabia (Pérez-Rodríguez, 2015), where breast cancer with localization in the upper outer quadrant was the most prevalent type (Alotaibi et al, 2018). The existence of the greatest quantity of glandular tissue in the upper outer quadrant of the breast is occasionally linked as a potential explanation for the frequent localization of breast cancer.…”

Section: Discussionsupporting

confidence: 91%

Study on Breast Cancer in Kazakhstan Using the Functional Time Series

Shertaeva

Ospanova

Grjibovsky

et al. 2023

Asian Pac J Cancer Prev

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Aim:In Kazakhstan and Central Asia, breast cancer (BC) is the most common malignancy among women. However, no large-scale study on breast cancer using the functional time series approach has been carried out in Kazakhstan. Methods: A functional assessment of the age-period-cohort model (APC) and the survival rate (period 2017-2021) was used in the retrospective study. Clinical and demographic information on patients was analysed, including age, gender, region of residence, kind and stage of tumour, occupation, socioeconomic standing, nationality, and specifics of treatment and its outcomes. Additionally, the relationship between nationality, stage, and residency region and the survival rate of breast cancer patients was investigated too. Results: The data of n=22,736 breast cancer patients were analysed. The highest number of breast cancer cases reported was 4,945 (21.7%), in 2019. In 2021, n =4,939 (21.7%) cases were detected, while in 2020, n=4,222 (18.6%) cases were observed. The patients with breast cancer in stages I and Ia were recognized in 6,585 (29% of cases), while those in stages Ib and Ic were confirmed in 8687 (38.2% of cases). In n=10,147 (44.6%) cases, a malignant tumour of the upper outer quadrant of the breast (C50.4) was predominant. Kazakhs made up the majority (n=10,939, 48.1%) of patients with a primary validated diagnosis of breast cancer, followed by Russians (n=7527, 33.1%). Germans had the lowest survival rate overall (11.4 ± 1.7 months) (p ≤ 0.05) (95% CI: 8.0-14.7 months). Uzbeks showed relatively high survival rates of 18.3 ± 1.6 months (95% CI: 15.1-21.5 months) (p ≤ 0.05). The Aktobe region had the lowest breast cancer survival rates, measuring 12.1±0.9 months (95% CI: 10.3-13.9 months) (p ≤ 0.05). The highest survival rates, 18.0±1.3 months (95% CI: 15.5-20.5 months) and 17.9±1.4 months (95% CI: 15.3-20.7 months), were seen in Shymkent and Zhambyl regions (p ≤ 0.05), respectively. The prevalence of breast cancer increases after 37.5 years, according to the results of the APC analysis, with an indicator of 0.572 (95% CI: -0.41 -1.56), maintaining a steady upward trend in the age range from 42.5 years to 62.5 years. Conclusions: Despite a slight drop in the disease's frequency, the incidence of breast cancer in women 37.5 years and older has been stable over the past five years. Additionally, it was shown that the country's northern regions had a higher incidence of breast cancer cases than the southern and western regions. Our results show the significance of demographic characteristics such as age and location for the development of preventive measures and effective treatment.

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“…Analisando o perfil imuno-histoquímico dos casos apresentados, o mais prevalente foi o Luminal A conforme dados encontrados na literatura (22,30,33) . Porém o triplo negativo se apresentou mais prevalente do que o Luminal B (30,33) , divergindo do nosso estudo onde o Luminal B aparece mais prevalente que o triplo negativo corroborando com o trabalho de Yábar et al (2017) (34) .…”

Section: Discussionunclassified

Perfil histológico e imuno-histoquímico das pacientes com câncer de mama operadas no Hospital Santa Casa de Curitiba no período de 2014 e 2015

Raffo

Hubie

Zanini

et al. 2018

Arq Med Hosp Fac Cienc Med Santa Casa São Paulo

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Objetivos: Identificar tipo histológico e perfil imuno-histoquímico das pacientes operadas por câncer de mama no Hospital Santa Casa de Curitiba. Correlacionar se os tipos histológicos mais agressivos são também de pior prognóstico imuno-histoquímico. Métodos: Estudo retrospectivo, observacional e analítico com 26 pacientes, no qual foram avaliadas as variáveis: sexo, idade, histologia, painel imuno-histoquímico (luminal A, luminal B, HER2 positivo e triplo negativo). Resultados: O sexo mais prevalente foi o feminino (96,2%), a média de idade foi 58 anos, o tipo histológico mais encontrado foi carcinoma ductal invasor (57,7%). No painel imuno-histoquímico a prevalência foi do subtipo luminal A (53,8%) seguidos pelos luminal B (30,8%), HER2 positivo (7,7%) e triplo negativo (7,7%). Na análise da relação histológica e imuno-histoquímica 57,1% dos carcinomas ductais invasores são luminais A e o carcinoma pouco diferenciado é triplo negativo. Os mistos foram distribuídos em luminal A (66,7%) e luminal B (33,3%). Os mucinosos dividiram-se igualmente em luminal A, luminal B e triplo negativo. O lobular invasor teve distribuição igual entre luminal A e B. Conclusões: O sexo feminino foi o mais prevalente, a média de idade apresentou um platô acima do encontrado na literatura, o tipo histológico mais incidente nas pacientes acompanhadas foi o carcinoma ductal invasor. No painel imuno-histoquímico a prevalência foi do subtipo luminal A, seguidos pelos luminal B, HER2 positivo e triplo negativo. Os tipos histológicos menos agressivos são mais comuns e também apresentam perfil imuno-histoquímico de melhor prognóstico e os mais agressivos são de pior prognóstico e menos responsivos aos tratamentos.

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Prevalence of breast cancer sub-types by immunohistochemistry in patients in the Regional General Hospital 72, Instituto Mexicano del Seguro Social

Cited by 8 publications

References 18 publications

Clinical, Histopathological, and Immunohistochemical Characteristics of Predictive Biomarkers of Breast Cancer: A Retrospective Study

Clinical, Histopathological, and Immunohistochemical Characteristics of Predictive Biomarkers of Breast Cancer: A Retrospective Study

Study on Breast Cancer in Kazakhstan Using the Functional Time Series

Perfil histológico e imuno-histoquímico das pacientes com câncer de mama operadas no Hospital Santa Casa de Curitiba no período de 2014 e 2015

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