Prevalence of Bordetella hinzii in mice in experimental facilities in Japan

Hayashimoto, Nobuhito; Morita, Hanako; Yasuda, Masahiko; Ishida, Tomoko; Kameda, Shuko; Takakura, Akira; Itoh, Toshio

doi:10.1016/j.rvsc.2011.11.001

Cited by 16 publications

(22 citation statements)

References 5 publications

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“…Our study is the first to report a natural infection of Bordetella pseudohinzii in captive mouse colonies in China. The infection rate (41/3094) was 1.32%, which is consistent with another study reported in Japan . Furthermore, the bacteria could be detected in almost all the mice species studied, including C57BL/6 mice, BALB/c mice, ICR sentinel mice, immunodeficient mice, and transgenic mice.…”

Section: Resultssupporting

confidence: 90%

Isolation and characterization of Bordetella pseudohinzii in mice in China

Huang

Luo

et al. 2019

Anim Models and Exp Med

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We report on the first detection and isolation of B. pseudohinzii (Bordetella pseudohinzii) in laboratory mice in China. Forty‐one B. pseudohinzii strains were isolated from 3094 mice in 33 different laboratory animal facilities in southern China. The isolates were identified through culture and genome sequenceing. Phylogenetic analysis based on the sequences of 16S rRNA and OmpA genes demonstrated that these strains were on the same clade as other B. pseudohinzii strains isolated from mice. Experimental infected mice presented an asymptomatic infection. B. pseudohinzii replicated in both the respiratory tract and the digestive tract. Most importantly B. pseudohinzii shed via feces and infected a group of sentinel mice in a separate cage via cage padding contaminated with B. pseudohinzii‐positive feces, indicating that B. pseudohinzii could transmit efficiently among mice and contaminate environmental facilities. Our study highlights the importance of routine monitoring of the pathogen in laboratory mice and provides vital insights into the transmission of Brodetellae in rodents and human.

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Section: Resultssupporting

confidence: 90%

Isolation and characterization of Bordetella pseudohinzii in mice in China

Huang

Luo

et al. 2019

Anim Models and Exp Med

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“…hinzii (Garhart, 2002). Isolation of an organism identified as B. hinzii from a laboratory mouse with bronchopneumonia in Japan (Hayashimoto et al , 2008) led to an assessment of this organism’s prevalence in multiple Japanese animal facilities that identified 195 isolates from 44 different facilities (Hayashimoto et al , 2012). Further studies reported isolation of B.…”

mentioning

confidence: 99%

“…AB444711) indicate that Japanese isolate 3224 (Hayashimoto et al , 2008) and 195 additional ‘ B. hinzii ’ that were cultured from tracheal swabs from mice in experimental facilities in Japan (Hayashimoto et al , 2012) may similarly prove to be B. pseudohinzii .…”

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confidence: 99%

Identification and taxonomic characterization of Bordetella pseudohinzii sp. nov. isolated from laboratory-raised mice

Ivanov

Linz

et al. 2016

International Journal of Systematic and Evolutionary Microbiology

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Bordetella hinzii is known to cause respiratory disease in poultry and has been associated with a variety of infections in immunocompromised humans. In addition, there are several reports of B. hinzii infections in laboratory-raised mice. Here we sequenced and analysed the complete genome sequences of multiple B. hinzii-like isolates, obtained from vendor-supplied C57BL/6 mice in animal research facilities on different continents, and we determined their taxonomic relationship to other Bordetella species. The whole-genome based and 16S rRNA gene based phylogenies each identified two separate clades in B. hinzii, one was composed of strains isolated from poultry, humans and a rabbit whereas the other clade was restricted to isolates from mice. Distinctly different estimated DNA–DNA hybridization values, average nucleotide identity scores, gene content, metabolic profiles and host specificity all provide compelling evidence for delineation of the two species, B. hinzii – from poultry, humans and rabbit – and Bordetella pseudohinzii sp. nov. type strain 8-296-03T (=NRRL B-59942T=NCTC 13808T) that infect mice.

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“…However, B. hinzii can also opportunistically infect immunocompromised humans, leading to conditions such as respiratory disease, septicemia, and cholangitis ( 2 – 5 ). Rodents have been proposed to serve as reservoirs for B. hinzii ( 6 , 7 ), suggesting that this species may be an emerging zoonotic pathogen. Therefore, comparative genomics of B. hinzii isolated from different sources is needed to elucidate any virulence mechanisms defining the host range in this species.…”

Section: Genome Announcementmentioning

confidence: 99%