Prevalence of Blindness and Outcomes of Cataract Surgery in Hainan Province in South China

Li, Emmy Y.; Liu, Yingpeng; Zhan, Xingkai; Liang, Yuan Bo; Zhang, Xiu Juan; Zheng, Chongren; Jhanji, Vishal; Xu, Ping; Chang, David F.; Lam, Dennis S.C.

doi:10.1016/j.ophtha.2013.04.003

Cited by 40 publications

(24 citation statements)

References 30 publications

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“…At present, most of the previous cataract-related epidemiological studies in Mainland China focused on the prevalence of cataract. [7][8][9][10][11][12] Only the Beijing Eye Study (conducted in 2001) studied the disease history factors and demonstrated that age was the most important risk factor; furthermore, myopic refractive error and self-reported diabetes were also risk factors for nuclear and cortical cataract, respectively. 9 However, their study was generally based on disease review questionnaires instead of detailed physical examinations or serum biological analyses.…”

Section: Introductionmentioning

confidence: 99%

Risk factors of age‐related cataract in a Chinese adult population: the Taizhou Eye Study

Tang

Wang

et al. 2017

Clinical Exper Ophthalmology

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Section: Introductionmentioning

confidence: 99%

Risk factors of age‐related cataract in a Chinese adult population: the Taizhou Eye Study

Tang

Wang

et al. 2017

Clinical Exper Ophthalmology

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“…It is associated with several complications like hyperlipidemia, retinopathy and cardiovascular diseases which are major causes of morbidity and death [1]–[3]. WHO has projected that by 2030 diabetes would become 7 th leading cause of death globally [4].…”

Section: Introductionmentioning

confidence: 99%

Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase

et al. 2014

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Diabetes mellitus is a multifactorial metabolic disease characterized by post-prandial hyperglycemia (PPHG). α-amylase and α-glucosidase inhibitors aim to explore novel therapeutic agents. Herein we report the promises of Dioscorea bulbifera and its bioactive principle, diosgenin as novel α-amylase and α-glucosidase inhibitor. Among petroleum ether, ethyl acetate, methanol and 70% ethanol (v/v) extracts of bulbs of D. bulbifera, ethyl acetate extract showed highest inhibition upto 72.06 ± 0.51% and 82.64 ± 2.32% against α-amylase and α-glucosidase respectively. GC-TOF-MS analysis of ethyl acetate extract indicated presence of high diosgenin content. Diosgenin was isolated and identified by FTIR, 1H NMR and 13C NMR and confirmed by HPLC which showed an α-amylase and α-glucosidase inhibition upto 70.94 ± 1.24% and 81.71 ± 3.39%, respectively. Kinetic studies confirmed the uncompetitive mode of binding of diosgenin to α-amylase indicated by lowering of both Km and Vm. Interaction studies revealed the quenching of intrinsic fluorescence of α-amylase in presence of diosgenin. Similarly, circular dichroism spectrometry showed diminished negative humped peaks at 208 nm and 222 nm. Molecular docking indicated hydrogen bonding between carboxyl group of Asp300, while hydrophobic interactions between Tyr62, Trp58, Trp59, Val163, His305 and Gln63 residues of α-amylase. Diosgenin interacted with two catalytic residues (Asp352 and Glu411) from α-glucosidase. This is the first report of its kind that provides an intense scientific rationale for use of diosgenin as novel drug candidate for type II diabetes mellitus.

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“…Subsequent to the 2006 Nine-Province Survey, additional local surveys were carried out in the provinces of Guangdong, 9,10 Heilongjiang, 11,12 Sichuan, 13 Jiangxi, 14 Yunnan, 15 Hainan, 16 and Jiangsu. 17,18 Although these more recent studies provided useful information on the magnitude and burden of vision impairment and blindness in localized areas, they did not offer an adequate basis for representative estimates regarding the prevalence of vision impairment and blindness among adult populations across rural China.…”

mentioning

confidence: 99%

Prevalence of Vision Impairment in Older Adults in Rural China in 2014 and Comparisons With the 2006 China Nine-Province Survey

Zhao

Ellwein

et al. 2018

American Journal of Ophthalmology

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PURPOSE: To estimate the prevalence of vision impairment and blindness in 2014 among older adults in rural China with comparisons with the 2006 Nine-Province Survey. DESIGN: Population-based, cross-sectional study. METHODS: Geographical cluster sampling was used in randomly selecting residents from a rural county or semi-rural district within 9 provinces: Beijing, Jiangsu, Guangdong, Heilongjiang, Jiangxi, Hebei, Ningxia, Chongqing, and Yunnan. Persons 50 years of age or older were enumerated through household visits and invited to examination sites for visual acuity testing and examination. Vision impairment and blindness in 2014 was compared with data from the 2006 survey. RESULTS: Among 51 310 examined persons, the prevalence of presenting vision impairment (<20/63 to ≥20/400) in the better-seeing eye ranged from 6.05% to 15.3% across the 9 study sites, with presenting blindness (<20/400) ranging from 0.66% to 5.35%. With best-corrected visual acuity, the prevalence of vision impairment ranged from 1.96% to 8.74%, and blindness from 0.47% to 5.01%. Vision impairment was associated with older age, female sex, and little or no education. The overall prevalence of presenting vision impairment and blindness decreased during the 2006–2014 interval by 6.31% and 29.0%, respectively; and by 16.1% and 38.0%, respectively, after standardization of 2006 prevalence rates to the 2014 population. CONCLUSIONS: Substantial progress has been made in the reduction of vision impairment in rural China. Nevertheless, vision impairment remains an important public health problem with substantial geographic disparities and with older age, female sex, and illiteracy as risk factors.

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Prevalence of Blindness and Outcomes of Cataract Surgery in Hainan Province in South China

Cited by 40 publications

References 30 publications

Risk factors of age‐related cataract in a Chinese adult population: the Taizhou Eye Study

Risk factors of age‐related cataract in a Chinese adult population: the Taizhou Eye Study

Diosgenin from Dioscorea bulbifera: Novel Hit for Treatment of Type II Diabetes Mellitus with Inhibitory Activity against α-Amylase and α-Glucosidase

Prevalence of Vision Impairment in Older Adults in Rural China in 2014 and Comparisons With the 2006 China Nine-Province Survey

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