Prevalence of Asthma and Asthma-Like Symptoms in Inner-City Schoolchildren

Mvula, Mosanda M.; Larzelere, Michele M.; Kraus, Marjorie; Moisiewicz, K.; Morgan, Connie; Pierce, Stephanie L.; Rm, Post; Nash, Theresa D; Moore, C.

doi:10.1081/jas-200044746

Cited by 35 publications

(29 citation statements)

References 40 publications

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“…ISAAC studies have shown that asthma prevalence is much higher in industrialized and western countries as compared to developing countries such as Asia and Africa [5]. In 2003 the ISAAC study in the urban city of Pune reported the prevalence of wheeze in the last 12 months to be 2.9% in school children aged 6-7 and 13-14 [6].…”

Section: Introductionmentioning

confidence: 99%

A Cross-Sectional Study to Find Prevalence and Risk Factors for Childhood Asthma in Pune City, India

Cheraghi

Dadgarinejad

Salvi³

2012

ISRN Public Health

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We aimed to determine current prevalence of asthma and risk factors associated with it in Pune, India. Methods. This was a crosssectional school-population-based study in which parents of school children aged 6-7 and 13-14 were administered an ISAAC questionnaire and an additional set of questions that detected the presence of potential risk factors known to be associated with asthma during 2008-2009 academic years. Results. Prevalence of current asthma was 6.7% (7% amongst 6-7-year olds and 6.3% amongst 13-14 year olds. Asthma was more common amongst boys (8.1%) than girls (4.9%) and more frequent in students studying in private schools (7.3%) than in those studying in public schools (5.8%). Risk factors such as family history of atopy, caesarian delivery, use of biomass fuel for cooking, absence of separate kitchen, absence of exclusive breastfeeding during the first 6 months of life, preterm birth, snoring, dampness at home, male sex, and parental smoking were significantly associated with asthma. Conclusion. There was a high prevalence of childhood asthma in Pune, India, which was associated with genetic and environmental risk factors.

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Section: Introductionmentioning

confidence: 99%

A Cross-Sectional Study to Find Prevalence and Risk Factors for Childhood Asthma in Pune City, India

Cheraghi

Dadgarinejad

Salvi³

2012

ISRN Public Health

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“…18 This strategy for ascertainment of a lifetime diagnosis has been used by the Centers for Disease Control and Prevention to assess prevalence of asthma and in multiple clinical research studies. [19][20][21] …”

Section: Clinical Definitions and Data Collectionmentioning

confidence: 99%

Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease

Bean

Boulet

Ellingsen

et al. 2012

Blood

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Sickle cell disease is a common hemolytic disorder with a broad range of complications, including vaso-occlusive episodes, acute chest syndrome (ACS), pain, and stroke. Heme oxygenase-1 (gene HMOX1; protein HO-1) is the inducible, rate-limiting enzyme in the catabolism of heme and might attenuate the severity of outcomes from vaso-occlusive and hemolytic crises. A (GT) n dinucleotide repeat located in the promoter region of the HMOX1 gene is highly polymorphic, with long repeat lengths linked to decreased activity and inducibility. We examined this polymorphism to test the hypothesis that short alleles are associated with a decreased risk of adverse outcomes (hospitalization for pain or ACS) among a cohort of 942 children with sickle cell disease. Allele lengths varied from 13 to 45 repeats and showed a trimodal distribution. Compared with children with longer allele lengths, children with 2 shorter alleles (4%; < 25 repeats) had lower rates of hospitalization for ACS (incidence rate ratio 0.28, 95%

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“…The semitropical climate, with high humidity and lack of winter frost, may increase the risk of multiple allergen exposure. 8,12 To fill the data gap on exposure to home dust allergens in asthmatic children living in the Gulf South, we measured level of dust mite (Der p 1, Der f 1), cockroach (Bla g 1), dog (Can f 1), and cat (Fel d 1) allergen in homes of children with asthma living in inner-city New Orleans.…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Indoor Allergen Exposures among New Orleans Children with Asthma

et al. 2007

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Studies of inner-city asthmatic children have shown significant regional variation in dust allergen exposures. The home environment of asthmatic children in the Gulf South region of the USA has not been characterized. This study describes indoor dust allergen levels in the homes of 86 asthmatic children in New Orleans and explores regional variability in dust allergen exposure. Data were used from baseline home visits of children in the New Orleans Healthy Homes Initiative. Interview, visual observation, and environmental dust sampling data of 86 children between 4 and 17 years of age were analyzed. Seventy-seven percent of households had moderate (92.0-9.9 mg/g) or high (Q10.0 mg/g) levels of either Der p 1 or Der f 1 dust mite allergen and 56.6% had moderate (92.0-8.0 U/g) or high (98.0 U/g) levels of cockroach allergen (Bla g 1). The prevalence of high (910 mg/g) levels of dog (Can f 1) allergen was 26.5%, and few households (6.0%) had high cat allergen (Fel d 1) levels (98.0 mg/g). Households with average humidity levels 950% were three times more likely to have elevated dust mite levels (odds ratio=3.2; 95% confidence interval=1.1, 9.3; p=0.03). Home ownership and education level were inversely associated with cockroach and dust mite allergen levels, respectively. Our findings reinforce the evidence of regional variability in dust allergen exposure levels. Asthmatic children living in the Gulf South are exposed to multiple indoor allergen exposures and live in a highly allergenic environment.

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Prevalence of Asthma and Asthma-Like Symptoms in Inner-City Schoolchildren

Cited by 35 publications

References 40 publications

A Cross-Sectional Study to Find Prevalence and Risk Factors for Childhood Asthma in Pune City, India

A Cross-Sectional Study to Find Prevalence and Risk Factors for Childhood Asthma in Pune City, India

Heme oxygenase-1 gene promoter polymorphism is associated with reduced incidence of acute chest syndrome among children with sickle cell disease

Prevalence of Indoor Allergen Exposures among New Orleans Children with Asthma

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