Prevalence of asthma

Anderson, Hugh

doi:10.1136/bmj.330.7499.1037

Cited by 53 publications

(19 citation statements)

References 8 publications

(9 reference statements)

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“…Asthma prevalence appears to have fallen in the UK over the last 10 years 1. New cases,2 asthma hospitalisations3 and acute asthma exacerbations in the community4 5 are all reported to be down.…”

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confidence: 99%

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Fewer colds, less asthma? A hypothesis to explain the fall in childhood asthma in the UK

2008

Journal of Epidemiology & Community Health

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UK asthma prevalence fell significantly between 1993 and 2000. In children aged <5 years hospital admissions for asthma fell by 52% and primary care presentations in children under 14 years by over 40%. From 1994 to 2000, primary care consultations for acute respiratory infections in all age groups fell by 36%, and for the common cold by 46%. Isolates for respiratory syncytial virus notified to the Health Protection Agency voluntary reporting scheme fell by 56% between 1993 and 2003. Falls in UK birth rate and improvements in living conditions were reported by the Office of National Statistics over this time. The authors hypothesise that the fall in asthma reflects a fall in respiratory infections, the most important proximal trigger for asthma exacerbations, and that this in turn may be related to a fall in household members to a number too low for effective virus transmission. Future research into the prevalence of asthma must consider the effect of changing respiratory virus burden on populations.

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confidence: 99%

“…The decline in new cases is most notable in preschool children, down by two thirds 6. Explanations considered elsewhere1 4 5 7 include changes in population atopic status, changes in aeroallergen exposure, atmospheric pollution, diet, increased inhaled corticosteroid (ICS) prescribing and diagnostic transfer.…”

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confidence: 99%

Fewer colds, less asthma? A hypothesis to explain the fall in childhood asthma in the UK

2008

Journal of Epidemiology & Community Health

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“…Representing a common pathogenic consequence of these complex antigenic challenges, allergic airway diseases have been hypothesized to develop during instances when the immune system of the lung fails to correctly discriminate between innocuous and harmful Ags. Over the last four decades of the twentieth century, the prevalence of allergic asthma increased substantially in industrialized countries (1), making a more detailed understanding of the pathogenic mechanisms of this allergic disease highly desirable.…”

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confidence: 99%

T Cell–Dendritic Cell Interaction Dynamics during the Induction of Respiratory Tolerance and Immunity

Bakočević

Worbs

Davalos-Misslitz

et al. 2009

The Journal of Immunology

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Dendritic cells (DCs) residing in the lung are known to acquire inhaled Ag and, after migration to the draining bronchial lymph node (brLN), to present it to naive T cells in an either tolerogenic or immunogenic context. To visualize endogenous lung-derived DCs, we applied fluorescent latex beads (LXs) intratracheally, thereby in vivo labeling the majority of phagocytic cells within the lung. Of note, LX-bearing cells subsequently arriving in the draining brLN were found to represent lung-derived migratory DCs. Imaging explanted brLN by two-photon laser-scanning microscopy, we quantitatively analyzed the migration and interaction behavior of naive CD4+ T cells and endogenous, lung-derived DC presenting airway-delivered Ag under inflammatory or noninflammatory conditions. Ag-specific naive CD4+ T cells engaged in stable as well as transient contacts with LX-bearing DCs in both situations and displayed similar overall motility kinetics, including a pronounced decrease in motility at 16–20 h after antigenic challenge. In contrast, the comparative analysis of T cell–DC cluster sizes as well as contact durations strongly suggests that lung-derived migratory DCs and naive CD4+ T cells form more stable, long-lasting contacts under inflammatory conditions favoring the induction of respiratory immunity.

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“…The prevalence of pediatric asthma increased steadily during the last part of the twentieth century among high income countries particularly the United States, Canada, New Zealand, Australia, and the United Kingdom (2)(3)(4)(5). Asthma is a major contributor to the burdenofillnessinchildren(6);itwasestimatedthatonaverage children miss around 13 million school days each year due to asthma (7).…”

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confidence: 99%

Medication Use in Australian Children with Asthma: User’s Perspective

Grover¹,

Armour²,

Asperen³

et al. 2013

Journal of Asthma

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This is one of the few research studies exploring the viewpoint of children with asthma about their medications in Australia. Despite investment in dissemination of professional, targeted evidence-based asthma management strategies in healthcare, there seems to be a lack of depth in terms of what parents understand about their child's asthma. Effective communication about medication usage, especially the inclusion of the child in the consultation to empower them to be involved in their own asthma care, may be the answer.

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Prevalence of asthma

Cited by 53 publications

References 8 publications

Fewer colds, less asthma? A hypothesis to explain the fall in childhood asthma in the UK

Fewer colds, less asthma? A hypothesis to explain the fall in childhood asthma in the UK

T Cell–Dendritic Cell Interaction Dynamics during the Induction of Respiratory Tolerance and Immunity

Medication Use in Australian Children with Asthma: User’s Perspective

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