Prevalence of antiphospholipid antibodies in deep vein thrombosis and their relationship to blood coagulation and fibrinolysis

Stegnar, Mojca; Božič, Borut; Peternel, Polona; Kveder, T; Vene, Nina; Rozman, B

doi:10.1016/0049-3848(91)90230-t

Cited by 27 publications

(17 citation statements)

References 18 publications

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“…Antiphospholipid antibodies seem to act against phospholipids on platelet and vascular endothelium membranes interfering with coagulation and fibrinolysis, thereby producing prothrombotic alterations [6]. These antibodies were found in patients with and without connective tissue disorders.…”

Section: Discussionmentioning

confidence: 98%

“…Antiphospholipid antibodies (aPL) comprise many antibody subgroups that show different characteristics of binding to phospholipids [ 1-31. aPL, namely anticardiolipin antibodies (aCL), act against phospholipid-P,-glycoprotein complex on platelet and vascular endothelium membranes [4,5] interfering with coagulation and fibrinolysis [6]. They have been detected in patients with systemic lupus erythematosus (SLE), other autoimmune disorders and, also in healthy population, with or without thrombosis .…”

Section: Introductionmentioning

confidence: 99%

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Fibrinolytic pattern in recurrent spontaneous abortions: No relationship between hypofibrinolysis and anti‐phospholipid antibodies

Gm¹,

Sartori²,

Ruffatti³

et al. 1994

American J Hematol

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Patients with antiphospholipid antibodies may suffer from thrombotic events and recurrent spontaneous abortions. A defective fibrinolytic potential has been described in women with recurrent fetal losses. We investigated the prevalence of anticardiolipin antibodies and of various fibrinolytic abnormalities in 64 females with a history of at least two abortions of unknown origin. Anticardiolipin antibodies were present in the serum of 31 patients (48.4%). The overall prevalence of fibrinolytic disorders was 67.2% (43 cases) and resulted significantly higher than that of aCL positivity (P = 0.03). In most of cases the impaired fibrinolytic potential after venous occlusion test was due to increased PAI-1 levels; only in a few instances a defective fibrinolytic response was due to reduced t-PA release, a combined defect or an intrinsic fibrinolytic deficiency. After division of patients in two groups on the basis of the aCL presence, the distribution of different fibrinolytic defects was similar in aCL positive and negative women, suggesting the lack of correlation between hypofibrinolysis and aCL antibodies. Plasminogen abnormalities resulted compatible with congenital hypoplasminogenemia in two aCL negative women, whereas in four aCL positive patients they were suggestive for acquired dysplasminogenemia. Our results indicate that patients with recurrent spontaneous abortions may present fibrinolytic disorders, which occur independently and more often than aCL positivity. An accurate investigation of the fibrinolytic potential, and, namely, of PAI-1 levels, should be included in the study of females suffering from repeated fetal losses.

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Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

Fibrinolytic pattern in recurrent spontaneous abortions: No relationship between hypofibrinolysis and anti‐phospholipid antibodies

Gm¹,

Sartori²,

Ruffatti³

et al. 1994

American J Hematol

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show abstract

“…Furthermore, in vitro data indicate that aPL alter the normal function of endothelial cells by impairing fibrinolysis [14], inducing tissue factor expression [15], inhibiting the release of prostacyclin [16], and by inducing their activation [17][18][19]. As endothelial cells are activated towards an apoptotic phenotype they become pro-adhesive and procoagulant through the expression of PS at the cell surface [20][21][22].…”

Section: Introductionmentioning

confidence: 99%

Phosphatidylserine Expression on Cell Surfaces Promotes Antibody-dependent Aggregation and Thrombosis in β2-glycoprotein I-immune Mice

Dombroski

Balasubramanian

Schroit

2000

Journal of Autoimmunity

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“…Anticardiolipin (aCL) and antiphosphatidylserine (aPS) antibodies of IgG and IgM isotypes were measured by enzyme-linked immunosorbent assay as described previously (Stegnar et al, 1991). Briefly, polystyrene plates (Linbro, Flow laboratories, McLean, VA, USA) were coated with 40 ml/well of either cardiolipin or phosphatidylserine in ethanol (Sigma Chemical Company, St. Louis, MO, USA) at a concentration of 40 mg/ml for both phospholipids and left open at 4 1C until evaporation.…”

Section: Laboratory Methodsmentioning

confidence: 99%

Anti-β2-glycoprotein I antibodies of IgM class are linked to thrombotic disorders in young women without autoimmune disease

et al. 2007

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Prevalence of antiphospholipid antibodies in deep vein thrombosis and their relationship to blood coagulation and fibrinolysis

Cited by 27 publications

References 18 publications

Fibrinolytic pattern in recurrent spontaneous abortions: No relationship between hypofibrinolysis and anti‐phospholipid antibodies

Fibrinolytic pattern in recurrent spontaneous abortions: No relationship between hypofibrinolysis and anti‐phospholipid antibodies

Phosphatidylserine Expression on Cell Surfaces Promotes Antibody-dependent Aggregation and Thrombosis in β2-glycoprotein I-immune Mice

Anti-β2-glycoprotein I antibodies of IgM class are linked to thrombotic disorders in young women without autoimmune disease

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