Prevalence of Antimicrobial Resistance in Respiratory Tract Isolates of Streptococcus pneumoniae : Results of a Canadian National Surveillance Study

Abstract

180 respiratory tract isolates of Streptococcus pneumoniae were collected from 18 medical centers in 9 of the 10 Canadian provinces. Penicillin-intermediate and -resistant isolates occurred at rates of 14.8 and 6.4%, respectively, and these rates varied considerably by geographic region. Trimethoprim-sulfamethoxazole, tetracycline, and macrolide rates of nonsusceptibility were 12.2, 10.6, and 8.0 to 9.3%, respectively. The most potent agents studied were newer fluoroquinolones.

Macrolide and Fluoroquinolone (Levofloxacin) Resistances among Streptococcus pneumoniae Strains: Significant Trends from the SENTRY Antimicrobial Surveillance Program (North America, 1997–1999)

“…1999). The baseline rate for the SENTRY Program (1997-1998) documenting a lower levofloxacin resistance rate (0.2 to 0.3%) was also observed by others (6,7).…”

Streptococcus pneumoniae: Does Antimicrobial Resistance Matter?

“…4,74,91,109 Pneumococci with amoxicillin 87,[164][165][166][167] TRUST 2004-2006, 93 and Doern et al 3,7 Figure 2 Penicillin-resistant Streptococcus pneumoniae (Canada, 1998 to 2006). Adapted from Wierzbowski et al 359 and Zhanel et al 91,272,334 MICs 4 mg/mL were noted in Spain and France, 139,143 but remain rare. These isolates are derived from four well-known Spanish MDR clones (Spain 23F -1, Spain 6V -2, Spain 9V -3, and Spain 14 -5).…”

“…Treatment failures due to PNSP (including Pc-I strains) have been documented for pneumococcal meningitis, 180-184 pneumonias, 48,49,67 Figure 3 Percent distribution of Streptococcus pneumoniae penicillin minimum inhibitory concentrations (Canada 1998 to 2006). Adapted from Zhanel et al 91,272,334 and Wierzbowski et al 359 and otitis media. [185][186][187] However, the impact of resistance on clinical outcomes has not been elucidated.…”

“…9,270 In Canada, rates of macrolide resistance from 1993 to 1998 ranged from 2.5 to 9.3%. 96,[271][272][273][274] Surveys in 2002 cited macrolide resistance rates of 13.9% 137 and 11.1%. 91 Recent Canadian data document macrolide resistance rates 19% (Fig.…”

“…Macrolide-resistant Streptococcus pneumoniae (CROSS-Canada 1993 to 2006). Adapted from Zhanel et al91,272,334 and Wierzbowski et al,229,359 from the Canadian Respiratory Organism Susceptibility Study (CROSS)(1993)(1994)(1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006).…”