Prevalence of and Risk Factors for Cognitive Impairment Among Elderly Without Cardio- and Cerebrovascular Diseases: A Population-Based Study in Rural China

Ren, Li; Bai, Lingling; Wu, Yanan; Ni, Jingxian; Shi, Min; Lu, Hongzhou; Tu, Jun; Ning, Xianjia; Lei, Ping; Wang, Jinghua

doi:10.3389/fnagi.2018.00062

Cited by 31 publications

(27 citation statements)

References 46 publications

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“…Findings of the current study are compared with these studies, and it is evident that prevalence of CI is more in patients with NCD. Existing data from other parts of the world suggest that the prevalence of dementia in patients with NCD ranges from 2.34 to 38.6% 73 74 75 76 77 78 and the current study also reported within range. Among patients with DM, the prevalence of CI in the present study was 13.63%.…”

Section: Discussionsupporting

confidence: 78%

Prevalence of Psychiatric Morbidity and Cognitive Impairment among Patients Attending the Rural Noncommunicable Disease Clinic

Mehra

Sangwan

Grover

et al. 2020

JNRP

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Objective This study aimed to assess the prevalence of cognitive impairment and psychiatric morbidity among the patients attending the rural noncommunicable disease clinic after controlling for various confounders (i.e., psychological morbidity, obesity, gender, level of education, duration of the illness and age). Methods One-hundred twenty-four patients were evaluated on the Hindi Mental State Examination for the cognitive function, Physical Health Questionnaire-9 for depression, and Generalized Anxiety Disorder-7 for anxiety disorders. Results About one-fourth (26.6%) of the participants had cognitive impairment. The prevalence of cognitive impairment was more among patients with hypertension (35.5%) as compared with the diabetes mellitus (13.6%) and those with comorbid hypertension and diabetes mellitus (26.6%). About one of the participants had depression (35.5%) and 29% of the patients had anxiety disorder. No significant difference was found in the level of cognitive deficits between those with hypertension and diabetes mellitus, when the confounding factors were not taken into account in the analysis. However, after controlling for psychiatric morbidity, obesity, gender, level of education, duration of the illness and age, those with hypertension were found to have significantly higher level of cognitive impairment compared with those with diabetes mellitus. A higher level of dysfunction was seen in the domains of orientation, registration, attention, recall, language, and visuospatial domains. Conclusion Present study suggests that patients of hypertension have higher level of cognitive impairment, when compared with those with diabetes mellitus, even after controlling for various confounders. Lack of difference between the two groups can be accounted by the confounding variables.

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Section: Discussionsupporting

confidence: 78%

Prevalence of Psychiatric Morbidity and Cognitive Impairment among Patients Attending the Rural Noncommunicable Disease Clinic

Mehra

Sangwan

Grover

et al. 2020

JNRP

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“…We used multiple linear regression and stepwise method to analyze the relationship between MMSE scores and potential factors. Based on past research [41,42], we selected the following independent variables: sex, age (years), education level, hypertension, diabetes, cardiovascular diseases, hyperlipidemia, prior stroke events, cerebral trauma, smoking, number of missing index teeth, and grouped number of missing index teeth (i.e., 0-6 and 7-10). The dependent variable was MMSE score.…”

Section: Statistical Analysesmentioning

confidence: 99%

Poor oral health conditions and cognitive decline: Studies in humans and rats

Zhang¹,

Yang²,

Wang³

et al. 2020

PLoS ONE

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Background The relationship between poor oral health conditions and cognitive decline is unclear. Objective To examine the association between oral health and cognition in humans and rats. Methods In humans: a cross-sectional study was conducted. Cognitive levels were evaluated by the Mini Mental State Examination (MMSE); oral conditions were reflected by the number of missing index teeth, bleeding on probing, and probing pocket depth (PD). In rats: a ligatureinduced (Lig) periodontitis model and Aβ 25-35-induced model of Alzheimer's disease (AD) were established; tumor necrosis factor-α (TNF-α), interleukin 1 (IL-1), interleukin 6 (IL-6), and C-reactive protein levels in the hippocampus and cerebral cortex were detected. Results MMSE scores for the number of missing index teeth � 7 group were significantly lower than those in the � 6 group. A negative relationship (correlation coefficient ρ = −0.310, P = 0.002) was observed between MMSE scores and number of missing index teeth. More missing index teeth and lower education levels were independent risk factors for cognitive decline. A negative relationship (correlation coefficient ρ = −0.214, P = 0.031) was observed between MMSE scores and average PD. TNF-α and IL-6 levels in the hippocampus of the Lig+AD group were significantly higher than those of the AD group. IL-1 and IL-6 levels in the cerebral cortex of the Lig+AD group were significantly higher than those of the AD group. Conclusion Poor oral health conditions including more missing index teeth and higher average PD may be risk factors for cognitive decline. Periodontitis may increase inflammatory cytokines in rat models of AD.

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“…In addition, a relevant variability of MCI prevalence across different immigrant groups was observed [18]. Such heterogeneity can be attributed to various determinants (e.g., vascular risk factors, educational level, lifestyles, physical activity, social interactions [19][20][21]) that have robustly been associated with the risk of cognitive disturbances and that were unavailable for the present analysis. The decision to base our analysis on the data produced by the COSMIC collaboration [14] (and not on other MCI prevalence data available in the literature) stems from the aim of providing different estimates of the phenomenon of interest according to alternative operationalizations of MCI that are widely adopted in the routine practice.…”

Section: Discussionmentioning

confidence: 92%

Mild Cognitive Impairment in the Migrant Population Living in Europe: An Epidemiological Estimation of the Phenomenon

Canevelli

Zaccaria

Lacorte

et al. 2020

JAD

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Background: The construct of mild cognitive impairment (MCI) is triggering growing clinical and research interest. The detection of MCI may be affected by diverse ethno-cultural determinants possibly influencing the personal and social perception of the individual cognitive functioning as well as the reliability of objective cognitive assessment. These challenges may acquire special relevance in subjects with a migration background and composing ethnic minority groups. Objective: The present study is aimed at providing an estimate of the number of MCI cases occurring in the migrant population living in the extended European Union (EU) in 2018. Methods: The number of MCI cases in older migrants living in Europe and in each of the 32 considered countries was estimated by multiplying the number of migrants, provided by Eurostat, with the age-specific prevalence rates, derived by the harmonized data produced by the COSMIC collaboration and based on different operational definitions of MCI. Results: Nearly 686,000 cases of MCI were estimated in the extended EU by applying age-specific prevalence rates based on the International Working Group criteria. Higher figures were obtained when the Clinical Dementia Rating-and the Mini Mental State Examination-based criteria were applied. The proportion of MCI cases in migrant subjects ranged from 1.1% (Romania) to 54.1% (Liechtenstein) (median: 8.4%; IQR: 4.7%-14.2%). Conclusions: MCI represents and will increasingly constitute a relevant issue in the migrant population living in Europe. The present data reinforce the need of developing approaches and models of care that may be diversity-sensitive and inclusive for a culturally variegated population.

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Prevalence of and Risk Factors for Cognitive Impairment Among Elderly Without Cardio- and Cerebrovascular Diseases: A Population-Based Study in Rural China

Cited by 31 publications

References 46 publications

Prevalence of Psychiatric Morbidity and Cognitive Impairment among Patients Attending the Rural Noncommunicable Disease Clinic

Prevalence of Psychiatric Morbidity and Cognitive Impairment among Patients Attending the Rural Noncommunicable Disease Clinic

Poor oral health conditions and cognitive decline: Studies in humans and rats

Mild Cognitive Impairment in the Migrant Population Living in Europe: An Epidemiological Estimation of the Phenomenon

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