Prevalence of alveolar bone deffect pattern in periodontitis patients with diabetes mellitus using bitewing radiography

Nainggolan, Lidya Irani; Gunasagaran, Lavaneya

doi:10.15562/jdmfs.v3i2.739

Cited by 3 publications

(3 citation statements)

References 6 publications

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“…Periodontal bone defects are highly prevalent in Indonesia, where the incidence has increased throughout the last decade. 1 2 According to data from Riset Kesehatan Dasar, the prevalence of this disease in 2007 was 23.4%. This increased to 25.9% in 2013 and the most recent data in 2018 reports a prevalence of 57.6%.…”

Section: Introductionmentioning

confidence: 99%

Role of Hydroxyapatite and Ellagic Acid in the Osteogenesis

et al. 2020

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Objective Ellagic acid (EA), a phenolic antioxidant, has benefits in bone health and wound healing. The combination of EA and hydroxyapatite (HA) (EA-HA) is expected to increase osteogenesis. The aim of this study was to analyze osteogenesis after application of EA-HA according to the number of osteoblasts and osteoclasts in the bone and the expression of the receptor activator of nuclear factor kappa- ligand (RANKL), osteoprotegerin (OPG), and osteocalcin (OCN) protein. Materials and Methods Thirty Wistar rats were assessed with bone defects created in the left femur. The defects were filled with EA-HA and then sutured. Control groups were filled with polyethylene glycol (PEG) or HA. Each group was sacrificed either 7 or 14 days after treatment. Results The defects filled with EA-HA exhibited the highest number of osteoblasts and the greatest expression of OPG and OCN at both day 7 and day 14 (p = 0.000). Conversely, treatment with EA-HA resulted in lower numbers of osteoclasts and reduced RANKL staining at both time points (p = 0.000). Conclusions EA-HA can increase osteogenesis in bone defects by increasing the number of osteoblasts and the expression of OPG and OCN.

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Section: Introductionmentioning

confidence: 99%

Role of Hydroxyapatite and Ellagic Acid in the Osteogenesis

et al. 2020

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“…This study proves that Low Intensity Pulse Ultrasound (LIPUS) therapy with a frequency parameter of 3 MHz, intensity of 0.5 W/cm 2 , duty cycle 20%, exposed for 3 minutes every day for 7 days, can significantly reduce MMP-9 expression and increase the epithelial thickness after skin excision of Diabetes Mellitus type 2 rat models. 29…”

Section: Original Researchmentioning

confidence: 99%

Effect of low intensity pulse ultrasound on the neutrophil function and epithelial thickness after skin excision in diabetes mellitus type 2 rats’ model (an immunohistochemistry study on matrix metalloproteinase-9)

Laraswati¹,

Hasan²,

Dwirahardjo³

2021

J Dentomaxillofac Sci

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Objective: To determine the effect of Low Intensity Pulse Ultrasound (LIPUS) on the neutrophil function and epithelial thickness after skin excision in diabetes mellitus type 2 rats' model (an Immunohistochemistry Study on Matrix Metalloproteinase-9). Material and Methods: Thirty-six Sprague dawley rats were divided into six groups: DM2, DM4, DM7, DML2, DML4, and DML7, each of which consist of 6 rats. Rats that matched the inclusion criteria were made into diabetes mellitus type 2 by injecting Nicotinamide and Streptozotocin. In all rat's excision wound was made with punch biopsy in the back area. DML group received LIPUS therapy in the wound area (frequency: 3 MHz, intensity: 0.5 W/cm2, duty cycle: 20%, duration: 3 minutes every day) for two days (DML2), four days (DML4) and seven days (DML7). In the wound tissue an immunohistochemical examination was performed with Polyclonal Antibody MMP-9 to observe MMP-9 expression and and Periodic Acid-Schiff staining to observe epithelial thickness. Results: Two-Way ANOVA and Post-Hoc LSD test showed lower level of MMP-9 expressions in the DML group than in the DM group, whereas the epithelial thickness in the DML group was found higher than in the DM group. The Pearson test showed a correlation between the level of MMP-9 expressions and epithelial thickness (p=0.000; r=-0.785). Conclusion: LIPUS therapy reduced MMP-9 expression and increases epithelial thickness.

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“…La limitación en el número de radiografías periapicales jugó un papel preponderante en los datos obtenidos en el presente estudio, presentando datos discordantes en términos de severidad y patrón de pérdida ósea en relación con diversas investigaciones. Nainggolan (16) en Indonesia con radiografías periapicales de diabéticos demostró que los niveles de pérdida ósea de mayor a menor fueron 52% moderada, 33.8% severa y leve con 14.1%; en este estudio el patrón de pérdida ósea más frecuente fue el horizontal representado por el 76,3% versus el patrón vertical con el 23.7%. Asimismo difiere con los resultados de Díaz (17) en Perú, pues la pérdida ósea moderada fue más común en los pacientes diabéticos con una representación del 39.7%, seguida del nivel severo con el 30.2% y finalmente con el 28.6% la pérdida ósea leve; con respecto al patrón de pérdida, en los pacientes diabéticos no existe diferencia sustancial entre el patrón horizontal y vertical.…”

Section: Discussionunclassified

Influencia de diabetes mellitus tipo 2 en pacientes con periodontitis crónica

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Prevalence of alveolar bone deffect pattern in periodontitis patients with diabetes mellitus using bitewing radiography

Cited by 3 publications

References 6 publications

Role of Hydroxyapatite and Ellagic Acid in the Osteogenesis

Role of Hydroxyapatite and Ellagic Acid in the Osteogenesis

Effect of low intensity pulse ultrasound on the neutrophil function and epithelial thickness after skin excision in diabetes mellitus type 2 rats’ model (an immunohistochemistry study on matrix metalloproteinase-9)

Influencia de diabetes mellitus tipo 2 en pacientes con periodontitis crónica

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