Prevalence of Age-Related Macular Degeneration in an Elderly Urban Chinese Population in China: The Jiangning Eye Study

Ye, Hehua; Zhang, Qi; Liu, Xiaohong; Cai, Xiushan; Yu, Wenjing; Yu, Siyi; Wang, Tianyu; Lu, Wuyi; Li, Xiang; Jin, Haiying; Hu, Yue; Kang, Xiaoli; Zhao, Peiquan

doi:10.1167/iovs.14-14899

Cited by 45 publications

(33 citation statements)

References 35 publications

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“…This suggests there are racial differences that are significant for explaining the AMD epidemiological pattern. The present study also finds there is a lower rural prevalence for late AMD in comparison to that in the urban areas of China,5 Taiwan13 18 and Singapore,3 which suggests that regional development may account for different AMD characteristics in the Chinese population. This finding is in keeping with the results of the HDES conducted in northern rural China 8…”

Section: Discussionsupporting

confidence: 61%

Prevalence of age-related macular degeneration in rural southern China: the Yangxi Eye Study

et al. 2017

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Section: Discussionsupporting

confidence: 61%

Prevalence of age-related macular degeneration in rural southern China: the Yangxi Eye Study

et al. 2017

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“…The study design and the details of the population sampling for the Jiangning Eye Study have been described elsewhere 19. Informed written consent was obtained from all participants before enrolment.…”

Section: Methodsmentioning

confidence: 99%

Prevalence and associations of epiretinal membrane in an elderly urban Chinese population in China: the Jiangning Eye Study

Zhang

Liu

et al. 2015

Br J Ophthalmol

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“…Several population-based studies on the prevalence of AMD have been performed in Asia. Prevalence estimates for early AMD and late AMD range from 2.5%–13.8% to 0.2%–7.0%, respectively, with higher prevalence in older study populations [3,11,12,13,14,15,16,17,18,19,20,21,22,23]. …”

Section: Epidemiologymentioning

confidence: 99%

Polypoidal Choroidal Vasculopathy in Asians

Wong

Cheung

2015

JCM

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Age related macular degeneration (AMD) in Asians has been suggested to differ from their Western counterparts in terms of epidemiology, pathogenesis, clinical presentation and treatment. In particular, polypoidal choroidal vasculopathy (PCV) appears to be the predominant subtype of exudative AMD in Asian populations, in contrast to choroidal neovascularization secondary to AMD (CNV-AMD) in Western populations. Epidemiological data on PCV has been largely limited to hospital-based studies and there are currently no data on the incidence of PCV. Similarities and differences in risk factor profile between PCV and CNV-AMD point to some shared pathogenic mechanisms but also differential underlying mechanisms leading to the development of each phenotype. Serum biomarkers such as CRP, homocysteine and matrix metalloproteinases suggest underlying inflammation, atherosclerosis and deranged extracellular matrix metabolism as possible pathogenic mechanisms. In addition, recent advances in genome sequencing have revealed differences in genetic determinants of each subtype. While the standard of care for CNV-AMD is anti-vascular endothelial growth factor (VEGF) therapy, photodynamic therapy (PDT) has been the mainstay of treatment for PCV, although long-term visual prognosis remains unsatisfactory. The optimal treatment for PCV requires further clarification, particularly with different types of anti-VEGF agents and possible benefits of reduced fluence PDT.

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Prevalence of Age-Related Macular Degeneration in an Elderly Urban Chinese Population in China: The Jiangning Eye Study

Abstract: The prevalence of early and late AMD in this urban Chinese sample was higher than that reported in the Beijing and Handan studies. Age-related macular degeneration is highly prevalent among the elderly urban Chinese population in mainland China. : Chinese Abstract.

Cited by 45 publications

References 35 publications

Prevalence of age-related macular degeneration in rural southern China: the Yangxi Eye Study

Prevalence of age-related macular degeneration in rural southern China: the Yangxi Eye Study

Prevalence and associations of epiretinal membrane in an elderly urban Chinese population in China: the Jiangning Eye Study

Polypoidal Choroidal Vasculopathy in Asians

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