Prevalence and associations of epiretinal membrane in an elderly urban Chinese population in China: the Jiangning Eye Study

Ye, Hehua; Zhang, Qi; Liu, Xiaohong; Cai, Xiushan; Yu, Wenjing; Yu, Siyi; Wang, Tianyu; Lu, Wuyi; Li, Xiang; Hu, Yue; Yang, Bo; Zhao, Peiquan

doi:10.1136/bjophthalmol-2015-307050

Cited by 47 publications

(45 citation statements)

References 22 publications

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“…This intraethnic variation was not fully explained by age or other potential confounders. In keeping with our finding, the Multi-Ethnic Study of Atherosclerosis also demonstrated that ERM prevalence was highest among Chinesecompared with other non-Asian populations 4 16. However, other studies in Chinese have reported lower prevalence rates than that of our study,17 although differences in participant characteristics and methodology in ERM assessment preclude direct comparison with our results.…”

Section: Discussionsupporting

confidence: 82%

Prevalence and risk factors for epiretinal membrane: the Singapore Epidemiology of Eye Disease study

et al. 2016

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Section: Discussionsupporting

confidence: 82%

Prevalence and risk factors for epiretinal membrane: the Singapore Epidemiology of Eye Disease study

et al. 2016

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“…In further evaluation of the remaining 18 articles, 10 were excluded for the following reasons: 6131435363738 did not report the risk factor of smoking; 351139 could not provide essential data after contacting the corresponding authors and 115 did not meet the definition of smoking. In the end, two cohort studies1018 and six cross-sectional studies91216174041 met our criteria (Fig. 1).…”

Section: Resultsmentioning

confidence: 99%

The Association between Smoking and Epiretinal Membrane

Wang

Tong

Wang

et al. 2016

Sci Rep

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We conducted a meta-analysis of analytic and observational studies to evaluate the association between smoking and epiretinal membrane (ERM). The pertinent studies were identified via a literature search using three databases (MEDLINE, Cochrane Library, Embase) and the reference lists of retrieved studies. Cohort, case-control and cross-sectional studies meeting the predefined criteria were included. We extracted the odds ratios (OR) and 95% confidence intervals (CI) from each study. Overall risk estimates were pooled using random-effects models. Subgroup analyses based on several stratified factors were also performed. Two cohort studies and six cross-sectional studies involving 46,837 subjects were included. The pooled effect of all eight studies showed an unexpected significant decreased association between smoking and the occurrence of ERM (OR, 0.72; 95% CI 0.61–0.84; p = 0.29, I2 = 17.9%). Subgroup analyses supported this finding, except for the age-unadjusted group (OR, 0.87; 95% CI 0.63–1.22), the ERM classification group (cellophane macular reflex (CMR) OR, 0.93; 95% CI 0.68–1.28; preretinal macular fibrosis (PMF) OR, 0.74; 95% CI 0.41–1.32), the Asian group (OR, 0.75; 95% CI 0.52–1.09) and the past smoker group (OR, 1.02; 95% CI 0.85–1.22). The pooled effects from the current literature suggested a declining association between smoking and ERM, which requires further studies to confirm.

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“…The prevalence rate of iERM in those aged 50 or older was recently estimated to be 7.7%, which is higher than that of early age-related macular degeneration (6.8%)23. The development of iERM basically requires the remnant of posterior vitreous cortex on the surface of the posterior retina as well as the migration and proliferation of Müller glial cells, both of which are triggered by posterior vitreous detachment4567.…”

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Pathologic Roles of Receptor-Associated Prorenin System in Idiopathic Epiretinal Membrane

Dong

Kanda

Noda

et al. 2017

Sci Rep

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Receptor-associated prorenin system (RAPS) refers to the pathogenic mechanism whereby prorenin binding to (pro)renin receptor [(P)RR] dually activates tissue renin-angiotensin system (RAS) and RAS-independent signaling via (P)RR. The aim of this study is to determine the association of RAPS with idiopathic epiretinal membrane (iERM). Reverse transcription-PCR indicated the expression of RAPS components, including (P)RR and Ang II type 1 receptor (AT1R), in iERM tissues and human Müller glial cell line. Double-labeling analyses demonstrated that (P)RR and AT1R were detected in cells positive for glial fibrillary acidic protein, a marker for glial cells, and co-localized with prorenin and angiotensinogen, respectively. Administration of prorenin to Müller glial cells enhanced mRNA expression of fibroblast growth factor 2, while Ang II application stimulated the expression of glial cell line-derived neurotrophic factor, nerve growth factor, and transforming growth factor-β1. These expression levels induced by prorenin or Ang II were reversed by (P)RR or AT1R blockade, respectively. Immunofluorescence revealed tissue co-localization of (P)RR and AT1R with the products of the upregulated genes in vitro. The present findings suggest the involvement of RAPS in the pathogenesis of iERM.

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Prevalence and associations of epiretinal membrane in an elderly urban Chinese population in China: the Jiangning Eye Study

Abstract: The prevalence of ERM in elderly urban Chinese was similar to that in Caucasians. Risk factors for idiopathic ERM were older age, female gender, myopia and hyperlipaemia.

Cited by 47 publications

References 22 publications

Prevalence and risk factors for epiretinal membrane: the Singapore Epidemiology of Eye Disease study

Prevalence and risk factors for epiretinal membrane: the Singapore Epidemiology of Eye Disease study

The Association between Smoking and Epiretinal Membrane

Pathologic Roles of Receptor-Associated Prorenin System in Idiopathic Epiretinal Membrane

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