Prevalence of Age-related Macular Degeneration in Elderly Caucasians: The Tromsø Eye Study

Erke, Maja Gran; Bertelsen, Geir; Pető, Tünde; Sjølie, Anne Katrin; Lindekleiv, Haakon; Njølstad, Inger

doi:10.1016/j.ophtha.2012.03.016

Cited by 49 publications

(53 citation statements)

References 28 publications

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“…Regarding NV-AMD, our total prevalence (0.44%) was lower than that reported in other countries, such as the 0.9% rate described in the Beaver Dam Eye Study [11], the 0.7% in the Rotterdam Study [18], the 1.2% in the Blue Mountains Eye Study [16], the 1.5% in the Alienor Study [23], the 1.4% in the Thessaloniki Eye Study [20], and also the 2.5% in the Tromso Eye Study [27]. Despite this, our rate is close to that reported by the Visual Impairment Project, i.e.…”

Section: Discussionmentioning

confidence: 93%

“…This software incorporates the International Classification Grading System, thus allowing a comparison with other major AMD European studies, such as the Rotterdam Study [18], the EUREYE Study [19], the Reykjavik Eye Study [21], and the Tromso Eye Study [27]. Studies like the Beaver Dam Eye Study [11] and the Blue Mountains Eye Study [16] used the Wisconsin Age-Related Maculopathy Grading System, which makes data comparisons with them more challenging.…”

Section: Discussionmentioning

confidence: 99%

“…Despite all these data, in Europe all reports refer almost exclusively to the northern countries (e.g. the Rotterdam Study [18], the EUREYE Study [19], the Reykjavik Eye Study [21] and the Tromso Eye Study [27]). …”

Section: Introductionmentioning

confidence: 99%

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Prevalence of Age-Related Macular Degeneration in Portugal: The Coimbra Eye Study - Report 1

Cachulo

Lobo²,

Figueira

et al. 2015

Ophthalmologica

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Purpose: To evaluate the age- and gender-specific prevalence of early and late age-related macular degeneration (AMD) in a Portuguese population-based sample. Methods: All patients aged ≥55 years of a Portuguese primary health-care unit were recruited for a cross-sectional population-based study. Responders underwent complete ophthalmological examination and digital fundus imaging. Early and late AMD was defined according to the International Age-Related Macular Epidemiological Study Group Classification, and the adopted staging for AMD was the same as that used in the Rotterdam study. The age- and gender-adjusted prevalence of early and late forms of AMD was calculated. Results: Of the 4,370 eligible subjects, 3,000 underwent study procedures (68.6% response rate) and 2,975 were included in the analysis; they had a mean age of 68.9 ± 8.6 years. The overall prevalence of early and late AMD was 15.53% (95% CI 14.25-16.88) and 0.67% (95% CI 0.41-1.04), respectively. Neovascular AMD (NV-AMD) and geographic atrophy (GA) accounted for 0.44% (95% CI 0.23-0.75) and 0.27% (95% CI 0.12-0.53) of individuals, respectively. The highest prevalence of advanced AMD was among those aged ≥75 years (1.13% for NV-AMD; 0.63% for GA). Conclusions: To our knowledge, this is the first AMD epidemiological study in a Portuguese population. The early forms of the disease had a similar prevalence to that of other large-scale population-based cohorts, but late AMD was less frequent than previously reported.

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Section: Discussionmentioning

confidence: 93%

Section: Discussionmentioning

confidence: 99%

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Prevalence of Age-Related Macular Degeneration in Portugal: The Coimbra Eye Study - Report 1

Cachulo

Lobo²,

Figueira

et al. 2015

Ophthalmologica

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“…While signs of AMD are rare in individuals younger than 50 years of age, several studies have indicated that up to one third of the population over the age of 75 show clinical hallmarks of various stages of the disease. Late stage AMD with severely affected visual acuity is present in up to 10% of subjects over 80 years [2,3,6,7]. Apart from ageing, several other risk factors such as smoking, a positive family history of AMD, hypertension, obesity, previous cataract surgery and hyperopia have also been consistently identified [8][9][10].…”

Section: Age-related Macular Degenerationmentioning

confidence: 99%

Oxidative stress-related damage of retinal pigment epithelial cells : possible protective properties of autophagocytosed iron-binding proteins

Karlsson¹

2015

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“…15 Details on the grading procedure and quality control have been described previously. 16,17 Photographs were graded for predominant phenotype determined by the most severe lesion present within the macula. Categories were late AMD (choroidal neovascularization or geographic atrophy), large drusen (4125 mm), intermediate drusen (63-125 mm), and normal phenotype (no drusen or drusen o63 mm).…”

Section: Data Collectionmentioning

confidence: 99%

Cognitive function, drusen, and age-related macular degeneration: a cross-sectional study

Lindekleiv

Erke

Bertelsen

et al. 2013

Eye

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Purpose To examine the cross-sectional relationship between drusen, late age-related macular degeneration (AMD), and cognitive function. Methods We included 2149 stroke-free participants from the population-based Tromsø Study in Norway. Retinal photographs were graded for presence of drusen and AMD. Cognitive function was assessed using the verbal memory test (short verbal memory), digit-symbol coding test (processing speed), and the tapping test (psychomotor tempo). We assessed the relationship between drusen, late AMD, and cognitive test scores, adjusted for potential confounders. Results Late AMD was associated with decreased performance in the verbal memory test (standardized b ¼ À 0.23, 95% confidence interval (CI): À 0.51 to À 0.01). Intermediate and large drusen were associated with decreased performance in the digit-symbol coding test (standardized b ¼ À 0.14 and -0.19, 95% CIs: À 0.23 to À 0.05 and À 0.29 to À 0.09, respectively). Participants with large drusen were more likely to have test scores in the lowest quartile of the digit-symbol coding test (odds ratio (OR) ¼ 1.9, 95% CI: 1.1-3.5) and the tapping test (OR ¼ 1.6, 95% CI: 1.0-2.6), but not in the verbal memory test (OR ¼ 1.0, 95% CI: 0.6-1.6). Conclusions The findings suggest a relationship between drusen deposition and reduced cognitive function. Although the relationships between drusen, late AMD, and the cognitive test results varied in strength and significance across the types of cognitive test, and may partly have been caused by residual confounding, it is not unlikely that a genuine but weaker relationship exists between drusen deposition and cognitive decline.

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Prevalence of Age-related Macular Degeneration in Elderly Caucasians: The Tromsø Eye Study

Cited by 49 publications

References 28 publications

Prevalence of Age-Related Macular Degeneration in Portugal: The Coimbra Eye Study - Report 1

Prevalence of Age-Related Macular Degeneration in Portugal: The Coimbra Eye Study - Report 1

Oxidative stress-related damage of retinal pigment epithelial cells : possible protective properties of autophagocytosed iron-binding proteins

Cognitive function, drusen, and age-related macular degeneration: a cross-sectional study

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