Prevalence of Adherent-Invasive Escherichia coli with fimH Gene Isolated from Iranian Patients with Ulcerative Colitis

Asiabar, Akram Sarabi; Aghdaei, Hamid Asadzade; Sabokbar, A; Zali, Mohammad Reza; Feizabadi, Mohammad Mehdi

doi:10.5812/jjm.13858

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…Nevertheless, recent studies have shown that the fimH gene does not show any significant association with AIEC pathotype; this gene has been detected in both AIEC and non-AIEC strains [30]. However, a higher rate of the fimH gene has been reported in AIEC strains isolated from biopsy samples of patients with UC com-pared to control subjects [62]. The FimH gene is the only gene that has been detected in all AIEC strains, mainly in B2 phylogenetic group E. coli [29].…”

Section: The Most Common Virulence Factors In Adherent-invasive Eschementioning

confidence: 96%

The role of major virulence factors and pathogenicity of adherent-invasive Escherichia coli in patients with Crohn’s disease

Abdelhalim¹,

Uzel²,

Ünal³

2020

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Section: The Most Common Virulence Factors In Adherent-invasive Eschementioning

confidence: 96%

The role of major virulence factors and pathogenicity of adherent-invasive Escherichia coli in patients with Crohn’s disease

Abdelhalim¹,

Uzel²,

Ünal³

2020

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The role of identified and characterized bacteriophage ZCEC13 in controlling pathogenic and multidrug-resistant Escherichia coli in wastewater: in vitro study

Ragab

Gouda

Abdelmoteleb

et al. 2023

Environmental Technology

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Phylogrouping and characterization of Escherichia coli isolated from colonic biopsies and fecal samples of patients with flare of inflammatory bowel disease in Iran

Nadalian

Houri

et al. 2022

Front. Med.

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BackgroundAlthough the etiopathogenesis of inflammatory bowel disease (IBD) is still poorly understood, Escherichia coli has been described as a potential causative microorganism in IBD pathogenesis and also disease progression, offering a potential therapeutic target for disease management. Therefore, we conducted this study to investigate the pathotypes, phylogenetic groups, and antimicrobial resistance of E. coli isolates from patients with IBD in Iran.MethodsFecal and biopsy colonic samples were collected from IBD patients experiencing flare-up episodes referred to Taleghani hospital in Tehran, Iran, between August 2020 and January 2021. Identification of E. coli strains was performed based on biochemical and molecular methods. Antibiotic susceptibility testing was performed as recommended by the Clinical and Laboratory Standards Institute. Phylogrouping and pathotyping of each isolate were carried out using polymerase chain reaction (PCR) and multilocus sequence typing (MLST) assays.ResultsA total of 132 non-duplicate E. coli strains were isolated from 113 IBD patients, including 96 ulcerative colitis (UC), and 17 Crohn’s disease (CD) patients. In our study, 55% of CD-related E. coli and 70.5% of UC-related isolates were non-susceptible to at least three or more unique antimicrobial classes, and were considered as multidrug-resistant (MDR) strains. E. coli strains exhibited a high level of resistance to cefazolin, ampicillin, tetracycline, ceftazidime, ciprofloxacin, and cefotaxime. Enterotoxigenic E. coli (ETEC) and diffusely adherent E. coli (DAEC) were the most prevalent pathotypes, and groups B2 and D were the predominant phylogroups.ConclusionIn the present study, we found that E. coli strains that colonize the gut of Iranian patients with IBD most frequently belonged to phylogenetic groups B2 and D. We also conclude that E. coli isolates from IBD patients have been revealed to be resistant to commonly used antibiotics, in which most of them harbored strains that would be categorized as MDR.

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Prevalence of Adherent-Invasive Escherichia coli with fimH Gene Isolated from Iranian Patients with Ulcerative Colitis

Cited by 3 publications

References 34 publications

The role of major virulence factors and pathogenicity of adherent-invasive Escherichia coli in patients with Crohn’s disease

The role of major virulence factors and pathogenicity of adherent-invasive Escherichia coli in patients with Crohn’s disease

The role of identified and characterized bacteriophage ZCEC13 in controlling pathogenic and multidrug-resistant Escherichia coli in wastewater: in vitro study

Phylogrouping and characterization of Escherichia coli isolated from colonic biopsies and fecal samples of patients with flare of inflammatory bowel disease in Iran

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