Prevalence of a positive TORCH and parvovirus B19 screening in pregnancies complicated by polyhydramnios

Pasquini, Lucia; Seravalli, Viola; Sisti, Giovanni; Battaglini, Carolina Orsi; Nepi, F.; Pelagalli, R.; Tommaso, Mariarosaria Di

doi:10.1002/pd.4769

Cited by 20 publications

(18 citation statements)

References 34 publications

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“…Among all patients we found only two cases with infection of Toxoplasma gondii (2.1%). It is similar to the results of the larger study by Pasquini et al [7] who found only 1% of patients with congenital infections and polyhydramnios, including two with Parvovirus B19 and one with Toxoplasma gondii. In both studies congenital infections were found only in patients with mild or moderate polyhydramnios.…”

Section: Discussionsupporting

confidence: 80%

Polyhydramnios — frequency of congenital anomalies in relation to the value of the amniotic fluid index

Kornacki

Adamczyk²,

Wirstlein³

et al. 2017

Ginekol Pol

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Objectives: The aims of our study were to assess the correlation between the amniotic fluid index (AFI) value and the frequency and type of fetal anomalies. Material and methods:The material included 94 patients at the third trimester of pregnancy, 60 with mild polyhydramnios, 19 with moderate one, and 15 with severe one. Polyhydramnios was diagnosed if AFI was > 24 cm. All patients were divided into three groups based on the value of AFI: 1) mild polyhydramnios with AFI between 24.1 and 29.9 cm, 2) moderate polyhydramnios with AFI between 30-34.9 cm, and 3) severe polyhydramnios with AFI ≥ 35 cm. Results:The incidence of fetal malformations correlated significantly with the degree of polyhydramnios and was the highest in patients with severe polyhydramnios (53.3%, p = 0.002). Congenital malformations of the gastrointestinal tract were the most frequent fetal anomalies in the whole group of patients (5.3%). Trisomy 18 was the most frequent aneuploidy found in women with polyhydramnios (2.1%). Conclusions:1. The incidence of fetal congenital anomalies significantly increases with the degree of polyhydramnios, being most frequent in severe one and rather rare in a mild one. 2. Congenital malformations of the gastrointestinal tract were the most frequent anomalies in patients with polyhydramnios, especially in women with severe polyhydramnios.

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Section: Discussionsupporting

confidence: 80%

Polyhydramnios — frequency of congenital anomalies in relation to the value of the amniotic fluid index

Kornacki

Adamczyk²,

Wirstlein³

et al. 2017

Ginekol Pol

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“…Authors of many separate studies on the relationship between intrauterine infections (TORCH, including parvovirosis) and polyhydramnios agree that such correlation is strongly doubtful. Therefore, it seems that in the cases of unexplained polyhydramnios, the diagnosis for TORCH is unjustified [22].…”

Section: Discussionmentioning

confidence: 99%

Follow-up of children with antenatally diagnosed idiopathic polyhydramnios

et al. 2019

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Objectives: The aim of our work was to assess the development of children with antenatally diagnosed idiopathic polyhydramnios, over 12 months from the end of pregnancy. Material and methods: The study included 91 healthy pregnant patients with idiopathic polyhydramnios. Diagnostic tests results and perinatal medical history were obtained retrospectively. Parents of children were contacted by phone and by mail. The answers were obtained from 64 (70%) parents. For statistical analysis SigmaStat3.5 software was used. Results: Ninety six percent of parents declared that in their opinion the development of children was normal. Abnormalities were found in 44% of the children. Thirty percent of neonates demonstrated mild abnormalities which may be due to organic or functional neuromuscular disorders: abnormal muscle tone, speech apparatus and development disorders, swallowing and breathing problems (manifested as vomiting, excessive regurgitation, idiopathic apnoeas). Isolated small malformations were diagnosed in 12 (19%) children. Two children (3%) with SGA were diagnosed with genetic syndromes. More than one of the abnormalities described above were diagnosed in 14% of children. Gestational age at the time of polyhydramnios diagnosis and its severity were not prognostic factors for abnormalities. Seventy percent of newborns were male. Conclusions: Despite the subjectively positive assessment of the development of children by the majority of parents, groups of common disorders requiring long-term follow-up have been identified. Functional disorders of the gastrointestinal tract, CNS and the group of neuromuscular disorders may be responsible for idiopathic polyhydramnios. SGA with co-existing idiopathic polyhydramnios is associated with the risk of genetic diseases. The more frequent incidence of idiopathic polyhydramnios in male fetuses requires further research.

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“…It is consistent with the observation of other authors. 9,12,13 There is an association of polyhydramnios with congenital malformation. 9 Six out of 27 patients with mild polyhydramnios (22%) had congenital malformations.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Congenital Anomalies in Polyhydramnios: A hospital based study from Western Nepal

2018

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Introduction: Polyhydramnios is excessive amount of amniotic fluid in relation to gestational age. It is frequently associated with congenital anomalies of the fetus. The aim of this study was to see the prevalence of congenital anomalies in polyhydramnios.Methods: Singleton pregnant irrespective of gestational age with amniotic fluid index more than 25 were included in the study. Degree of polyhydramnios was graded as mild, moderate and severe. Detail study of fetus was done for possible congenital anomalies. Congenital anomalies were confirmed with post-natal findings.Results: There were 39 pregnant women with amniotic fluid index (AFI) > 25 cm. Prevalence of polyhydramnios was 0.3%. Congenital anomalies were present in 31.6 % of pregnant women with polyhydramnios. In pregnant women with severe polyhydramnios; 66.6 % had congenital anomalies. Central nervous system, gastrointestinal and skeletal anomalies were the frequent anomalies associated with polyhydramnios.Conclusion: Polyhydramnios is associated with increased risk of congenital anomalies hence a detail survey of fetus should be done for possible congenital anomalies.

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Prevalence of a positive TORCH and parvovirus B19 screening in pregnancies complicated by polyhydramnios

Cited by 20 publications

References 34 publications

Polyhydramnios — frequency of congenital anomalies in relation to the value of the amniotic fluid index

Polyhydramnios — frequency of congenital anomalies in relation to the value of the amniotic fluid index

Follow-up of children with antenatally diagnosed idiopathic polyhydramnios

Prevalence of Congenital Anomalies in Polyhydramnios: A hospital based study from Western Nepal

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