Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study

Heeringa, Jan; Kuip, Deirdre A. M. van der; Hofman, Albert; Kors, Jan A.; Herpen, Gerard van; Stricker, Bruno H.; Stijnen, Theo; Lip, Gregory Y. H.; Witteman, Jacqueline C. M.

doi:10.1093/eurheartj/ehi825

Cited by 1,664 publications

(1,181 citation statements)

References 36 publications

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“…The prevalence of AF estimated in our study is somewhat higher than the estimates derived from the considerably older, population-based Rotterdam Study which was conducted between 1990 and 1999 (19). In this study, the prevalence of AF was 4.0% in the age-group 65-69 years (5.1% in our study) and similarly showed a marked increase with age.…”

Section: Discussioncontrasting

confidence: 72%

Incidence, prevalence and 1-year all-cause mortality of heart failure in Germany: a study based on electronic healthcare data of more than six million persons

et al. 2015

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CitationIncidence, prevalence and 1-year all-cause mortality of heart failure in Germany: a study based on electronic healthcare data of more than six million persons. Abstract AimsData on the epidemiology of atrial fibrillation (AF) and its antithrombotic management in elderly populations are scarce. The aims of this study were to estimate the incidence and prevalence of AF in the elderly in Germany and to describe antithrombotic management of AF cases. MethodsEstimation of prevalence and incidence was based on data of three German statutory health insurances, which insured more than 800,000 people aged 65 years and older in the study Treatment was less common among women and older people. ConclusionIncidence and prevalence of AF are relatively high in the elderly in Germany. A considerable fraction of new AF cases did not receive antithrombotic drugs in routine care.

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Section: Discussioncontrasting

confidence: 72%

Incidence, prevalence and 1-year all-cause mortality of heart failure in Germany: a study based on electronic healthcare data of more than six million persons

et al. 2015

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“…The lifetime risk is 1 in 4 according to previous studies,2, 3 and more than 1 in 3 based on recent data 4. Several risk factors have been identified, many of which are also risk factors for several types of cancer, such as age, smoking, alcohol consumption, and obesity 5, 6.…”

Section: Introductionmentioning

confidence: 96%

Atrial Fibrillation and Risk of Cancer: A Danish Population‐Based Cohort Study

Vinter

Christesen

Fenger‐Grøn

et al. 2018

JAHA

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BackgroundAtrial fibrillation (AF) and cancer are frequent diseases worldwide. The timewise association between the diagnosis of AF and a subsequent diagnosis of cancer may clarify whether a mutual cause exists, and may also guide clinicians about time windows of high risk of cancer occurrence.Methods and ResultsWe conducted a population‐based cohort study among 26 222 men and 28 879 women free of AF and cancer at baseline based on the Danish Diet, Cancer and Health study. The participants were followed for the development of AF (the Danish National Patient Registry) and subsequent cancer (the Danish Cancer Registry) until 2013. We used Cox proportional hazard models with new‐onset AF as time‐dependent exposure. The men (median age 56 years) and women (median age 56 years) were followed for medians of 16.7 and 19.6 years, respectively. AF was associated with higher risks of any type of cancer (men: hazard ratio [HR] 1.41, 95% confidence interval [CI], 1.26–1.58; women: HR 1.15, 95% CI, 1.02–1.32), and for men only, lung (HR 1.66, 95% CI, 1.19–2.30), and colorectal cancer (HR 1.37, 95% CI, 1.02–1.85). Within the initial 90 days following the diagnosis of AF, the risks of any type of cancer (men: HR 2.89, 95% CI, 2.10–3.98; women: HR 3.72, 95% CI, 2.49–5.56), lung (men: HR 7.70, 95% CI, 4.34–13.68; women: HR 7.98, 95% CI, 3.96–16.09), and colorectal cancer (men: HR 3.35, 95% CI, 1.03–10.90; women: HR 5.91, 95% CI, 2.44–14.29) were higher for men and women.ConclusionsA diagnosis of AF is associated with a higher incidence rate of cancer among men and women. The cancer incidence rate is particularly elevated within 90 days after the diagnosis of AF.

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“…Prevalence of AF sharply increases with age, and with our rapidly aging population, prevalence of AF is expected to double by 2060 2, 3. Cardioembolic stroke is one of the most common complications of AF, and at least 1 in 3 strokes is directly attributable to AF 4, 5.…”

Section: Introductionmentioning

confidence: 99%

Contact‐Free Screening of Atrial Fibrillation by a Smartphone Using Facial Pulsatile Photoplethysmographic Signals

Yan

Lai

Chan

et al. 2018

JAHA

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BackgroundWe aimed to evaluate a novel method of atrial fibrillation (AF) screening using an iPhone camera to detect and analyze photoplethysmographic signals from the face without physical contact by extracting subtle beat‐to‐beat variations of skin color that reflect the cardiac pulsatile signal.Methods and ResultsPatients admitted to the cardiology ward of the hospital for clinical reasons were recruited. Simultaneous facial and fingertip photoplethysmographic measurements were obtained from 217 hospital inpatients (mean age, 70.3±13.9 years; 71.4% men) facing the front camera and with an index finger covering the back camera of 2 independent iPhones before a 12‐lead ECG was recorded. Backdrop and background light intensity was monitored during signal acquisition. Three successive 20‐second (total, 60 seconds) recordings were acquired per patient and analyzed for heart rate regularity by Cardiio Rhythm (Cardiio Inc, Cambridge, MA) smartphone application. Pulse irregularity in ≥1 photoplethysmographic readings or 3 uninterpretable photoplethysmographic readings were considered a positive AF screening result. AF was present on 12‐lead ECG in 34.6% (n=75/217) patients. The Cardiio Rhythm facial photoplethysmographic application demonstrated high sensitivity (95%; 95% confidence interval, 87%–98%) and specificity (96%; 95% confidence interval, 91%–98%) in discriminating AF from sinus rhythm compared with 12‐lead ECG. The positive and negative predictive values were 92% (95% confidence interval, 84%–96%) and 97% (95% confidence interval, 93%–99%), respectively.ConclusionsDetection of a facial photoplethysmographic signal to determine pulse irregularity attributable to AF is feasible. The Cardiio Rhythm smartphone application showed high sensitivity and specificity, with low negative likelihood ratio for AF from facial photoplethysmographic signals. The convenience of a contact‐free approach is attractive for community screening and has the potential to be useful for distant AF screening.

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Prevalence, incidence and lifetime risk of atrial fibrillation: the Rotterdam study

Abstract: In this prospective study in a European population, the prevalence and incidence of AF increased with age and were higher in men than in women. The high lifetime risk to develop AF was similar to North American epidemiological data.

Cited by 1,664 publications

References 36 publications

Incidence, prevalence and 1-year all-cause mortality of heart failure in Germany: a study based on electronic healthcare data of more than six million persons

Incidence, prevalence and 1-year all-cause mortality of heart failure in Germany: a study based on electronic healthcare data of more than six million persons

Atrial Fibrillation and Risk of Cancer: A Danish Population‐Based Cohort Study

Contact‐Free Screening of Atrial Fibrillation by a Smartphone Using Facial Pulsatile Photoplethysmographic Signals

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