Prévalence des souches d'Acinetobacter baumannii et de Pseudomonas aeruginosa résistantes à l'imipénème par production de métallo-β-lactamases

Kadi, Mohamed Ait El; Aghrouch, Mohamed; Seffar, Myriam; Harti, Jaouad El; Bouklouze, A.; Cherrah, Yahia; Souly, K.; Zouhdi, Mimoun

doi:10.1016/j.medmal.2006.05.003

Cited by 7 publications

(4 citation statements)

References 9 publications

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“…PCR method was initially of simple use in detecting MBL-producing isolates but became more difficult with the increased number of types of MBLs; moreover, it is expensive for daily routine application in developing countries' laboratories as it is the case in Morocco. In 2010, the aim of this study was �rst to determine the prevalence of MBL among carbapenem resistant strains of Acinetobacter baumannii in our hospital, and second to compare this rate to the one found in 2005 [5].…”

Section: Introductionmentioning

confidence: 99%

Prevalence of Metallo-β-Lactamases ProducingAcinetobacter baumanniiin a Moroccan Hospital

Kabbaj

Seffar

Belefquih

et al. 2013

ISRN Infectious Diseases

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Objective. To determine the prevalence of metallo beta-lactamases (MBL) among carbapenem resistant strains of Acinetobacter baumannii in our hospital. Methodology. During a period of 12 months (January-December 2010), 47 isolates of Acinetobacter baumannii were collected from different clinical specimens of in-patients. Antimicrobial susceptibility was determined and interpreted using the disk diffusion method according to the Antibiogram Committee of the French Society for Microbiology guidelines. Imipenem nonsusceptible isolates were further screened for production of MBL. Results. All Acinetobacter baumannii' isolates were resistant to ticarcillin, ticarcilline/clavulanate, piperacillin, piperacillin/tazobactam, gentamicin, tobramycin, and cipro�oxacin, except an isolate that was sensitive to ceazidime and cefepime. In addition to that, amikacin and trimethoprim/sulfamethoxazole were, respectively, sensitive by 59.5% and 53%. Among 57,4% (27/47) imipenem non-susceptible isolates of Acinetobacter baumannii, 74% (20/27) were found to be MBL producers. Conclusion. Although the rate of imipenem nonsusceptible isolates of Acinetobacter baumanni seems to remain stable in 2005 (57%) and 2010 (57,5%), the prevalence of MBL producer strain is increasing (38% in 2005 versus 75% in 2010). e �ndings strongly suggest that there is a need to track the detection of MBL producers; moreover, a judicious use of carbapenems is necessary to prevent further spread of these organisms.

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Section: Introductionmentioning

confidence: 99%

Prevalence of Metallo-β-Lactamases ProducingAcinetobacter baumanniiin a Moroccan Hospital

Kabbaj

Seffar

Belefquih

et al. 2013

ISRN Infectious Diseases

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“…As is the case of a lot of countries, this bacterium is frequently isolated in Moroccan hospitals [11]. This study is the first of its kind to highlight the intestinal MDR A .…”

Section: Introductionmentioning

confidence: 81%

Intestinal carriage of antibiotic resistant Acinetobacter baumannii among newborns hospitalized in Moroccan neonatal intensive care unit

et al. 2019

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This study was conducted in order to assess the acquisition rate of Acinetobacter baumannii by newborn screening, on admission and during the discharge process of neonatal intensive care unit. (NICU). Furthermore, we investigated risk factors for potential colonization and molecular epidemiology of isolated resistant bacteria. This prospective study was conducted in the neonatal unit of Hassan II University Hospital of Fez from February 2013 to July 2015. During this period, all consecutive admitted neonates were screened for A. baumannii intestinal carriage, on admission and during the discharge process. Bacteriological and molecular tests were evaluated according to the international standards. This study examines the screening on admission of 455 newborns, 59% of whom were male. The average gestational age and birth weight were 35.2 weeks and 2612.1 g respectively. In total, 277 patients were included in the acquisition study on admission. The prevalence of multi-drug resistant (MDR) A. baumannii strain carriage was 6.5%, while the acquisition rate during the hospital recovery was 13.7%. In this study, 68 MDR A. baumannii isolates were collected. The resistance rates to different antibiotic classes including, Ceftazidime, Gentamycin and Ciprofloxacin varied between 92 and 100%. Moreover, 13% of MDR A. baumannii isolates were carbapenemase producers and 88% harbored blaOXA-23 gene. On admission, three risk factors were significantly associated with A. baumannii colonization: age (OR, 2.803; IC95%, 1.191–6.596; P = 0.01), gender (OR, 0.382; IC95%, 0.158–0.921; P = 0.03) and the delivery birth at the Maternity of University Hospital (MUH), (OR, 0.196; IC95%, 0.071–0.540; P = 0.002). However during hospitalization, the only risk factor associated with acquisition of A. baumannii was the respiratory distress (OR, 2.270; IC95%, 1.055–4.881; P = 0.03). A high intestinal carriage rate of A. baumannii and multiple antibiotic resistance were found in our NICU. Thus, the spread of MDR A. baumannii should be monitored by an active surveillance strategy.

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“…This phenomenon invariably affect everybody where the need of the proper use of antibiotics. In addition, the emergence of a resistant strain to imipenem which is supposed to represent a real alternative in the treatment of multi-resistant bacteria to beta lactam [8] is worrisome. So there is a real danger because it is clear that today, no antibiotic can escape the phenomenon of bacterial resistance, even in community-acquired infections.…”

Section: Discussionmentioning

confidence: 99%

Resistance to Beta Lactam Antibiotics of <i>Pseudomonas aeruginosa</i> Isolated in Community Infections within HIV Infected Persons in Lomé-Togo

Wateba¹,

Ekoue-Kouvahey²,

Balaka³

et al. 2014

WJA

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Prévalence des souches d'Acinetobacter baumannii et de Pseudomonas aeruginosa résistantes à l'imipénème par production de métallo-β-lactamases

Cited by 7 publications

References 9 publications

Prevalence of Metallo-β-Lactamases ProducingAcinetobacter baumanniiin a Moroccan Hospital

Prevalence of Metallo-β-Lactamases ProducingAcinetobacter baumanniiin a Moroccan Hospital

Intestinal carriage of antibiotic resistant Acinetobacter baumannii among newborns hospitalized in Moroccan neonatal intensive care unit

Resistance to Beta Lactam Antibiotics of <i>Pseudomonas aeruginosa</i> Isolated in Community Infections within HIV Infected Persons in Lomé-Togo

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Prévalence des souches d'Acinetobacter baumannii et de Pseudomonas aeruginosa résistantes à l'imipénème par production de métallo-β-lactamases

Cited by 7 publications

References 9 publications

Prevalence of Metallo-β-Lactamases ProducingAcinetobacter baumanniiin a Moroccan Hospital

Prevalence of Metallo-β-Lactamases ProducingAcinetobacter baumanniiin a Moroccan Hospital

Intestinal carriage of antibiotic resistant Acinetobacter baumannii among newborns hospitalized in Moroccan neonatal intensive care unit

Resistance to Beta Lactam Antibiotics of &lt;i&gt;Pseudomonas aeruginosa&lt;/i&gt; Isolated in Community Infections within HIV Infected Persons in Lom&#233;-Togo

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Resistance to Beta Lactam Antibiotics of <i>Pseudomonas aeruginosa</i> Isolated in Community Infections within HIV Infected Persons in Lomé-Togo