Prévalence des anticorps anti-VHC et incidence de séroconversion dans cinq centres d’hémodialyse au Maroc

Sekkat, Souad; Kamal, Nabiha; Benali, B.; Fellah, Hajiba; Amazian, K.; Bourquia, A.; Kholti, Abdeljalil El; Benslimane, A.

doi:10.1016/j.nephro.2007.11.007

Cited by 20 publications

(14 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, higher HCV prevalence rates reaching 35.1 and 42.4% are detected among special populations such as patients undergoing haemodialysis and haemophiliacs respectively 89,90,91…”

Section: Hepatitis C Virus (Hcv) Infectionmentioning

confidence: 99%

Viral hepatitis A to E in South Mediterranean Countries

Kamal¹,

Mahmoud²,

Hafez³

et al. 2010

Medit J Hematol Infect Dis

View full text Add to dashboard Cite

Viral hepatitis represents an important health problem in the South Mediterranean countries, Egypt, Libya, Tunisia, Algeria and Morocco. Emerging natural history and epidemiological information reveal differences in the overall epidemiology, risk factors and modes of transmission of viral hepatitis A, B, C, D, E infections in the South Mediterranean region. The differences in the in incidence and prevalence of viral hepatitis across North African countries is attributed to variations in health care and sanitation standards, risk factors and immunization strategies. The active continuous population movement through travel, tourism and migration from and to the South Mediterranean countries contribute to the spread of infections due to hepatitis viruses across borders leading to outbreaks and emergence of new patterns of infection or introduction of uncommon genotypes in other countries, particularly in Europe.

show abstract

“…However, higher HCV prevalence rates reaching 35.1 and 42.4% are detected among special populations such as patients undergoing haemodialysis and haemophiliacs respectively 89,90,91…”

Section: Hepatitis C Virus (Hcv) Infectionmentioning

confidence: 99%

Viral hepatitis A to E in South Mediterranean Countries

Kamal¹,

Mahmoud²,

Hafez³

et al. 2010

Medit J Hematol Infect Dis

View full text Add to dashboard Cite

show abstract

“…While several published Moroccan studies exist in the scientific literature on hemodialysis, haemophiliacs and chronic HCV-infected patients (Sekkak et al; Benouda et al; Benani et al; Benjelloun et al) [10,24-26], the IDU group in the Maghreb region has remained a largely under-studied cohort to date. Due to the paucity of published data, this study sought to characterize this elusive and high-risk group, as well as to elucidate key difference between it and other chronically HCV-infected patients in Morocco.…”

Section: Discussionmentioning

confidence: 99%

The “hidden” epidemic: a snapshot of Moroccan intravenous drug users

Trimbitas

Serghini²,

Lazaar

et al. 2014

Virol J

View full text Add to dashboard Cite

BackgroundHepatitis C virus is a persistent epidemiological problem, with an estimated 170 million individuals infected worldwide, and the leading cause of asymptomatic chronic infection, liver cirrhosis and hepatocellular carcinoma. Injection drug users (IDUs) have the highest seroprevalence as compared to chronic hemodialysis and transfusion patients, and this cohort remains the most under-studied high-risk group in North Africa to date. This study first sought to characterize the demographic, epidemiological, and genotypic profile of a total sample size of 211 chronically-infected IDUs living in the Tangier region of Northern Morocco, and secondly to contrast this to other chronically-infected patients, in order to uncover possible discrepancies.ResultsThe general ‘profile’ of local IDUs marks a stark contrast to chronically-infected HCV Moroccan patients, other African countries, and neighboring European countries. The majority of Moroccan drug users were found to be middle-aged and celibate. A relatively high seroprevalence was found among drug users (60%), and this increased with age. The majority of drug users shared their needles and this hold implications for transmission, as seropositive status was significantly different between those users that shared vs. those that did not share their needles. In addition, IDUs exhibited genotypes 1a and 3a predominantly, as compared to the predominant 1b and 2a/2c genotypes found in chronically HCV-infected patients. The IDU genotypic profile closely matches the one in other European countries (Portugal, Spain, France, and Italy), which are invariably speculated as the potential source of currently-circulating genotypes in Moroccan IDUs.ConclusionThese findings have implications for disease prevention, transmission and treatment, as this distinct IDU subgroup cannot be collectively pooled along with other HCV-positive high-risk groups. Local government, practitioners, and health institutions should take this into account when treating, prescribing antiviral therapy, and designing preventative public health campaigns.

show abstract

“…This is predominantly because these patients are more exposed to risk factors for the acquisition of this infection and also because they are monitored monthly by laboratory examinations that permit an early diagnosis of the infection 19 . The prevalence of HCV infection in hemodialysis patients can vary from 7% up to 70% in some countries 11,16 . Among the factors associated with higher HCV infection rates in hemodialysis patients are the time of dialysis and demographic region.…”

Section: Discussionmentioning

confidence: 99%

“…However, a significant variation in the importance of each of those factors in disease transmission was observed over time in each region 1 . The transmission of HCV in hemodialysis units merits special attention since it can occur by several routes 11,16 .The prevalence of HCV infection in patients undergoing dialysis is greater than that in the general population, suggesting that patients on dialysis may be at higher risk of acquiring HCV infection. This is predominantly because these patients are more exposed to risk factors for the acquisition of this infection and also because they are monitored monthly by laboratory examinations that permit an early diagnosis of the infection 19 .…”

mentioning

confidence: 99%

See 1 more Smart Citation

Hepatitis C virus infection in hemodialysis patients in Maracaibo, Venezuela

Monsalve-Castillo

Gómez-Gamboa

Chacín-Bonilla

et al. 2012

Rev. Inst. Med. trop. S. Paulo

View full text Add to dashboard Cite

Over a two year period, the incidence of hepatitis C virus (HCV) infection was evaluated in 29 hemodialysis patients, aged between 15 and 75 years (mean ± SD: 45 ± 39.5 years), from the University Hospital Hemodyalisis Unit, Maracaibo, Zulia State, Venezuela. Anti-HCV antibodies were determined using a fourth generation ELISA (Innotest HCV Ab IV) kit and positive blood samples were tested using a recombinant assay kit (Inno-LIA HCV Ab III), both kits from Innogenetics N.V., Belgium. The findings indicate a lack of HCV seroconversion in the hemodialysis patients over the study period, confirmed by the recombinant assay. Risk factors for HCV infection were 0.3270 (95% confidence interval: 0.01323-8.080) in patients undergoing hemodialysis. The findings suggest a lack of significant sources for HCV infection due to the preventive measures to avoid its transmission in the hemodialysis unit.

show abstract

Prévalence des anticorps anti-VHC et incidence de séroconversion dans cinq centres d’hémodialyse au Maroc

Cited by 20 publications

References 28 publications

Viral hepatitis A to E in South Mediterranean Countries

Viral hepatitis A to E in South Mediterranean Countries

The “hidden” epidemic: a snapshot of Moroccan intravenous drug users

Hepatitis C virus infection in hemodialysis patients in Maracaibo, Venezuela

Contact Info

Product

Resources

About