Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy: population based study

Pierrat, Véronique; Haouari, N.; Liška, Anita; Thomas, D.; Subtil, D.; Truffert, Patrick

doi:10.1136/adc.2003.047985

Cited by 165 publications

(125 citation statements)

References 20 publications

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“…However, the incidence of fever and of chorioamnionitis in our control group falls well within the range reported in several prospective studies, 4,16 and the incidence of encephalopathy in our study population was similar to those reported in previous population-based studies. 2,4,26 Using this database, we were unable to define what differentiated a diagnosis of 'intrapartum fever' from a diagnosis of 'chorioamnionitis' as fever is a defining factor in both syndromes. Previous studies often grouped these two diagnoses together or studied only those with clinical or histological chorioamnionitis.…”

Section: Discussionmentioning

confidence: 99%

Intrapartum fever and chorioamnionitis as risks for encephalopathy in term newborns: a case–control study

Blume

Loc’h

et al. 2007

Develop Med Child Neuro

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In this study we examined the relationship between diagnoses of isolated intrapartum fever or chorioamnionitis and the risk of encephalopathy in term newborns. We conducted a populationbased, case-control study in Washington State using 1994 to 2002 linked data from the Washington State Birth Registry and the Comprehensive Hospital Abstract Reporting System (CHARS). We identified 1060 singleton, term newborns (602 males, 458 females) with International Classification of Diseases (ICD-9) diagnoses consistent with encephalopathy, and 5330 unaffected control newborns (2756 males, 2574 females). Intrapartum fever was defined by a diagnosis of intrapartum temperature of >38˚C in the birth registry or CHARS databases. Chorioamnionitis was defined using ICD-9 diagnoses recorded in CHARS. We identified 2.2 cases of encephalopathy per 1000 births. Isolated intrapartum fever was associated with a 3.1-fold (95% confidence interval [CI] 2.3-4.2) increased risk of newborn encephalopathy. Chorioamnionitis was associated with a 5.4-fold (95% CI 3.6-7.8) increased risk of encephalopathy. We found that isolated intrapartum fever and chorioamnionitis were independently associated with an increased risk of encephalopathy in term infants. Our data also indicate that there is a spectrum of risk for encephalopathy in term infants exposed to intrapartum fever. Infants born to women with signs of chorioamnionitis other than isolated intrapartum fever may be at higher risk of encephalopathy than those exposed only to isolated intrapartum fever.

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Section: Discussionmentioning

confidence: 99%

Intrapartum fever and chorioamnionitis as risks for encephalopathy in term newborns: a case–control study

Blume

Loc’h

et al. 2007

Develop Med Child Neuro

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“…The duration and severity of HIE depend of the severity of asphyxia. Neonatal asphyxial encephalopathy occurs in 1-2 per 1000 births in the high income countries (Marlow & Budge, 2005;Pierrat et al, 2005;Barkovich, 2005), in low-income countries, the incidence is much higher (Ellis et al, 2000;Black et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Sonographic Changes in Hypoxic-Ischaemic Encephalopathy

Ilves¹

2012

Miscellanea on Encephalopathies - A Second Look

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“…1,2 Randomized clinical trials have demonstrated that moderate hypothermia is associated with a reduction in death and neurologic impairment at 18 to 22 months of age. 3,4 As a result, many centers now offer therapeutic hypothermia (TH) as a neuroprotective strategy for neonatal HIE.…”

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confidence: 99%

Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia

Nash¹,

Bonifacio²,

Glass³

et al. 2011

Neurology

156

128

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Prevalence, causes, and outcome at 2 years of age of newborn encephalopathy: population based study

Cited by 165 publications

References 20 publications

Intrapartum fever and chorioamnionitis as risks for encephalopathy in term newborns: a case–control study

Intrapartum fever and chorioamnionitis as risks for encephalopathy in term newborns: a case–control study

Sonographic Changes in Hypoxic-Ischaemic Encephalopathy

Video-EEG monitoring in newborns with hypoxic-ischemic encephalopathy treated with hypothermia

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