Prevalence and significance of thyroid autoantibodies in patients with chronic hepatitis C virus infection: a prospective controlled study

Huang, Miau‐Ju; Tsai, Shau‐Wei; Huang, Bie‐Yu; Sheen, I‐Shyan; Yeh, Chi-Ju; Liaw, Yun–Fan

doi:10.1046/j.1365-2265.1999.00686.x

Cited by 96 publications

(59 citation statements)

References 38 publications

(71 reference statements)

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“…However, some studies suggested that the prevalence of thyroid disease was also increased in CHC patients after exclusion of J Gastrointestin Liver Dis, June 2016 Vol. 25 No 2: 227-234 those being treated with IFN-α compared with normal subjects [6,7]. Besides, anti-thyroid antibodies had been found in sera of HCV infected subjects before IFN-α therapy [8,9].…”

Section: Introductionmentioning

confidence: 95%

“…In 6 studies [16,17,[20][21][22][23], the mean OR for TPOAb was 1.96 (95%CI 1.19-3.23), suggesting that the HCV group had a two-fold higher prevalence of TPOAb. ATMA was tested in only 5 studies [6,7,19,22,25]. The positive rate of ATMA in the HCV group was higher than that in the control group, with the pooled OR of 1.86 (95%CI 1.17-2.96) (Fig.1).…”

Section: Association Of Hcv Infection With the Prevalence Of Anti-thymentioning

confidence: 99%

“…Study characteristics are shown in Table I. The design of these studies was cross-sectional [17,22], case-control [7,16,[19][20][21]23] or cohort (prospective control) [6,18,24,25]. A total of 1,735 HCV-infected and 1,868 non-HCV infected subjects were involved.…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…TGAb was covered in 8 studies [7,15,17,18,[20][21][22][23], TPOAb in 6 studies [16,17,[20][21][22][23] and ATMA in 5 studies [6,7,15,19,22].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Shen

Wang

Xie

et al. 2016

JGLD

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Background & Aims: The involvement of thyroid autoimmunity and dysfunction in patients with chronichepatitis C virus (HCV) infection before interferon-α (IFN-α) therapy remains controversial. We performedthis meta-analysis to evaluate the association of HCV infection with the presence of anti-thyroid antibodiesand dysthyroidism. Methods: A literature search was carried out to collect articles dated up to August 2015 to identify observationalstudies which compared the prevalence of anti-thyroid antibodies and thyroid dysfunction in IFN-α naïvechronic HCV-infected subjects with non-HCV infected controls. Random-effect or fixed-effect meta-analyseswere applied and results reported as odds ratios (ORs) with 95% confidence intervals (CIs). Results: Twelve studies were included, involving 1,735 HCV-infected and 1,868 non-HCV infected subjects.Pooled anti-thyroid antibody prevalence tended to be higher in HCV-infected subjects. The prevalence ofanti-thyroglobulin antibody (TGAb), anti-thyroid peroxidase antibody (TPOAb), anti-thyroid microsomalantibody (ATMA) were 2.40-fold, 1.96-fold and 1.86-fold higher in HCV-infected subjects than in controls,respectively. The prevalence of hypothyroidism also differed by HCV infection status, with a pooled risk of3.10 (95%CI: 2.19-4.40) in HCV-infected subjects. However, the results did not show a significant differencein the prevalence of hyperthyroidism between the two groups.Conclusion: Chronic HCV infection may be an independent risk factor for thyroid disturbance. It is advisablefor the clinicians to monitor both thyroid antibodies and function in the course of chronic HCV infection,independent of IFN-α treatment. Abbreviations: AITD: autoimmune thyroid disease; ATMA: anti-thyroid microsomal antibody; CHC:chronic hepatitis; GD: Graves’ disease; HCV: hepatitis C virus; HT: Hashimoto’s thyroiditis; IFN-α: interferonalpha;NOS: Newcastle-Ottawa quality assessment scale; T3: triiodothyronine; T4: thyroxine; TGAb: antithyroglobulinantibody; TPOAb: anti-thyroid peroxidase antibody.

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Section: Introductionmentioning

confidence: 95%

Section: Association Of Hcv Infection With the Prevalence Of Anti-thymentioning

confidence: 99%

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

“…TGAb was covered in 8 studies [7,15,17,18,[20][21][22][23], TPOAb in 6 studies [16,17,[20][21][22][23] and ATMA in 5 studies [6,7,15,19,22].…”

Section: Characteristics Of the Included Studiesmentioning

confidence: 99%

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Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Shen

Wang

Xie

et al. 2016

JGLD

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“…75 Several studies have looked into associations between the development of autoimmune manifestations and HCV genotypes. 18,[76][77][78] Most studies did not find a significant correlation between the HCV genotype and the development of thyroid autoantibodies 18,76 or other autoantibodies. 76 One study from Taiwan showed an association between mixed infection with genotypes 1bϩ2b and the development of microsomoal (i.e., TPO) antibodies, 78 again suggesting viral genotype does not influence the predisposition to thyroid autoimmunity in patients infected with HCV.…”

Section: Non-genetic Factorsmentioning

confidence: 99%

The clinical and physiological spectrum of interferon-alpha induced thyroiditis: Toward a new classification

et al. 2006

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Interferon-alpha (IFN␣) is a major treatment modality for several malignant and nonmalignant diseases, especially hepatitis C. Prospective studies have shown that up to 15% of patients with hepatitis C receiving IFN␣ develop clinical thyroid disease, and up to 40% were reported to develop thyroid antibodies. Some of these complications may result in discontinuation of interferon therapy. Thus, interferon induced thyroiditis (IIT) is a major clinical problem for patients receiving interferon therapy. IIT can be classified as autoimmune type and non-autoimmune type. I nterferons were discovered in the 1950Јs and were immediately recognized for their ability to render cells resistant to virus infection. 1 Interferons have been classified into two major groups, type I interferons and type II interferons, based on their capacity to bind to common receptor types. Type I interferons bind to a type I interferon receptor and include interferon-␣, interferon-␤, interferon-, and interferon-. 2 Type II interferons bind to a distinct type II receptor and include interferon-␥. 2 In addition to their antiviral properties, interferons have immunomodulatory, antiangiogenic, antiproliferative and antitumor activity, and act as important regulators of growth and differentiation. 3 Interferons work by directly binding to either type I or type II receptors. The cytoplasmic domains of the transmembrane glycoproteins are associated with members of the JAK family of kinases. They activate various signaling pathways, including the JAK-STAT pathway, the Crk-pathway, the IRS signaling pathway, and the MAP kinase pathway, which leads to signal transduction and subsequent activation or repression of specific genes. 3,4 More than twenty interferon-induced proteins have been identified. 5 Interferon-alpha (IFN␣) was the first cytokine to be reproduced by recombinant DNA technology and has emerged as a major therapeutic modality for several malignant and nonmalignant diseases. Among the diseases treated by IFN␣ are melanoma, renal cell carcinoma, hairy cell leukemia, Kaposi's sarcoma, and hepatitis B and C. 5 However, the most common prescription for IFN␣

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Risk of Non-Hodgkin Lymphoma and Lymphoproliferative Precursor Diseases in US Veterans With Hepatitis C Virus

Giordano

Henderson

Landgren

et al. 2007

JAMA

304

221

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Prevalence and significance of thyroid autoantibodies in patients with chronic hepatitis C virus infection: a prospective controlled study

Cited by 96 publications

References 38 publications

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

Thyroid Disturbance in Patients with Chronic Hepatitis C Infection: A Systematic Review and Meta-analysis

The clinical and physiological spectrum of interferon-alpha induced thyroiditis: Toward a new classification

Risk of Non-Hodgkin Lymphoma and Lymphoproliferative Precursor Diseases in US Veterans With Hepatitis C Virus

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