Prevalence and severity of nonalcoholic fatty liver disease by transient elastography: Genetic and metabolic risk factors in a general population

Petta, Salvatore; Marco, V. Di; Pipitone, Rosaria Maria; Grimaudo, Stefania; Buscemi, Carola; Craxı̀, Antonio; Buscemi, Silvio

doi:10.1111/liv.13743

Cited by 76 publications

(68 citation statements)

References 40 publications

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“…The current study is similar to previously published population‐based studies using radiological methods as a first step to identify NAFLD patients with either significant or advanced fibrosis . Caballeria et al reported that 5.8% of the general Barcelona population had LSM by TE >8.0 kPa, with the majority of patients having NAFLD.…”

supporting

confidence: 89%

Editorial: choosing an appropriate risk stratification tool for nonalcoholic fatty liver disease—one size does not fit all

Shaheen

Swain

2020

Aliment Pharmacol Ther

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supporting

confidence: 89%

Editorial: choosing an appropriate risk stratification tool for nonalcoholic fatty liver disease—one size does not fit all

Shaheen

Swain

2020

Aliment Pharmacol Ther

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“…Additionally, previous studies have demonstrated that higher liver fibrosis scores (intermediate and high fibrosis score) are associated with increased liver disease‐related mortality in adults both in the United States and Korea . Transient elastography is considered to be a non‐invasive and reliable method for the assessment of liver fibrosis and can be reasonably used to quantify liver fibrosis in epidemiological research settings . Unfortunately, in our study, data on transient elastography or liver biopsy were not available because our study was based on de‐identified, retrospective cohort data from individuals who underwent a routine health check‐up programme in which transient elastography was not included.…”

Section: Discussionmentioning

confidence: 99%

Metabolically healthy versus unhealthy obesity and risk of fibrosis progression in non‐alcoholic fatty liver disease

Kim

Chang

Cho

et al. 2019

Liver International

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Background & Aims Little is known about the impact of metabolically healthy obesity on fibrosis progression in non‐alcoholic fatty liver disease (NAFLD). We investigated the association of body mass index (BMI) category, body fat percentage and waist circumference with worsening of noninvasive fibrosis markers in metabolically healthy and unhealthy individuals with NAFLD. Methods A cohort study was performed on 59 957 Korean adults with NAFLD (13 285 metabolically healthy and 46 672 metabolically unhealthy individuals) who were followed for a median of 7.7 years. Being metabolically healthy was defined as not having any metabolic syndrome component and having a homoeostasis model assessment of insulin resistance <2.5. Progression from low to intermediate or high probability of advanced fibrosis was assessed using the NAFLD fibrosis score (NFS). Results During 339 253.1 person‐years of follow‐up, 9857 subjects with low NFS at baseline progressed to intermediate or high NFS. Among metabolically healthy individuals, the multivariable‐adjusted HRs (95% CI) for NFS worsening comparing BMIs 23‐24.9, 25‐29.9 and ≥30 with a BMI of 18.5‐22.9 kg/m2 were 1.19 (1.00‐1.42), 1.79 (1.52‐2.10) and 3.52 (2.64‐4.69), respectively, whereas the corresponding HRs (95% CI) in metabolically unhealthy individuals were 1.37 (1.24‐1.52), 2.18 (1.99‐2.39) and 4.26 (3.83‐4.75). A similar trend was observed in the analyses using body fat and waist circumference. Conclusion In the large‐scale cohort of young and middle‐aged individuals with NAFLD, BMI was positively associated with worsening of noninvasive fibrosis marker regardless of metabolic health status. Excess adiposity per se, even without accompanying metabolic health status, may contribute to fibrosis progression in NAFLD.

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“…Few studies have reported on the prevalence of NAFLDrelated elevated liver stiffness in the general population. [24][25][26][27] Caballería and colleagues 26 found that 5.8% of a Spanish population had liver stiffness, as determined by a transient elastography result greater than 8.0 kPa; the majority of patients had NAFLD. In contrast, Koehler and colleagues 24 reported a prevalence of liver stiffness of 8.4% with the same cut-off value in a Dutch population.…”

Section: Discussionmentioning

confidence: 99%

Risk stratification of patients with nonalcoholic fatty liver disease using a case identification pathway in primary care: a cross-sectional study

Shaheen¹,

Riazi²,

Medellin³

et al. 2020

cmajo

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onalcoholic fatty liver disease (NAFLD) is common in patients with diabetes, obesity, dyslipidemia and metabolic syndrome, and has become the leading cause of liver disease in North America. 1,2 Patients with NAFLD at risk for advanced fibrosis require specialist care for urgent assessment and management of liver cirrhosis complications. 3,4 Intense lifestyle modification and treatment of underlying risk factors are the main approach for treating patients with NAFLD with advanced fibrosis. 3,5 Early clinical intervention and patient education lead to better outcomes, including possible reversal of histopathologic liver changes, especially in patients who achieve a 7%-10% weight loss. 6,7 Therefore, recent guidelines have emphasized the high yield of targeting patients with NAFLD who have advanced fibrosis for intense lifestyle modification. 3,5 Although awareness of NAFLD among primary care physicians is increasing, identifying patients with NAFLD

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Prevalence and severity of nonalcoholic fatty liver disease by transient elastography: Genetic and metabolic risk factors in a general population

Abstract: In a cohort of a general population, the prevalence of NAFLD was very high, and among NAFLD patients a significant proportion had advanced fibrosis (high LSM values). Apart from traditional risk factors, genetic factors may have a significant role that needs to be further investigated.

Cited by 76 publications

References 40 publications

Editorial: choosing an appropriate risk stratification tool for nonalcoholic fatty liver disease—one size does not fit all

Editorial: choosing an appropriate risk stratification tool for nonalcoholic fatty liver disease—one size does not fit all

Metabolically healthy versus unhealthy obesity and risk of fibrosis progression in non‐alcoholic fatty liver disease

Risk stratification of patients with nonalcoholic fatty liver disease using a case identification pathway in primary care: a cross-sectional study

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