Prevalence and Risk Factors of Postdialysis Fatigue in Patients Under Maintenance Hemodialysis: A Systematic Review and Meta-Analysis

You, Qi; Bai, Ding-xi; Wu, Chenxi; Chen, Huan; Hou, Chao-ming; Gao, Jing

doi:10.1016/j.anr.2022.11.002

Cited by 6 publications

(6 citation statements)

References 19 publications

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“…This divergence might be attributed to variations in study populations; our investigation focused on a hemodialysis cohort, while Wiltink et al examined the general population. Remarkably, the hemodialysis population exhibited pronounced somatic depressive symptoms, including fatigue, loss of appetite, and sleep disturbances, compared to the general population [17,19,20]. Consequently, the negative outcomes of our study might imply that the association between somatic depressive symptoms and DM could be obscured by the in uence of hemodialysis.…”

Section: Discussionmentioning

confidence: 58%

Short-Physical Performance Batter：Complete Mediator of Cognitive Depressive Symptoms and Diabetes Mellitus in Hemodialysis Patients

Zhang,

Chen,

Han

et al. 2024

Preprint

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Objective: This study aimed to examine the relationship between different dimensions of depressive symptoms and the presence of diabetes mellitus in hemodialysis patients. Additionally, the study sought to elucidate the mediating effect of physical performance on this association. Methods: This was a cross-sectional multicenter study conducted between July 2020 and March 2023, involving 1024 patients from eight hemodialysis centers in Shanghai. The study enrolled patients with physician diagnosis and blood glucose indicating diabetes mellitus. Physical performance and depressive symptoms were assessed using short-physical performance batter (SPPB) and the patient health questionnaire-9, respectively. Regression and mediation analysis were applied to statistical analysis. Results: Among the 1024 participants, 39.26% (n = 402) were found to have coexisting diabetes mellitus. Diminished SPPB scores (OR = 0.843, 95% CI = 0.792-0.897) and cognitive depressive symptoms (OR = 1.068, 95% CI = 1.011-1.129) exhibited significant associations with diabetes mellitus, while somatic depressive symptoms did not show a significant correlation. Notably, SPPB emerged as a complete mediator in the relationship between cognitive depressive symptoms and diabetes mellitus. The observed indirect effect of SPPB on this relationship was estimated at 0.038 (95% CI: 0.021-0.057). Conclusion: This investigation highlighted the pivotal role of cognitive depressive symptoms in influencing diabetes mellitus, with the SPPB acting as a complete mediator.

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Section: Discussionmentioning

confidence: 58%

Short-Physical Performance Batter：Complete Mediator of Cognitive Depressive Symptoms and Diabetes Mellitus in Hemodialysis Patients

Zhang,

Chen,

Han

et al. 2024

Preprint

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“…Following a hemodialysis treatment, many patients report feeling tired and needing rest or sleep. This condition, conventionally named post-dialysis fatigue (PDF), has been described as a feeling of being worn out, drained or exhausted [ 1 , 2 , 3 ]. PDF is one of the most debilitating symptoms of hemodialysis patients, significantly impairing their quality of life and causing frustration and depression [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

“…The causes and the pathogenesis of PDF are essentially unknown [ 1 , 2 , 3 , 4 ]. However, some mechanisms have been proposed, such as the rapid decline in osmolarity occurring during dialysis as result of the combined effect of a reduction in serum urea and sodium concentration (this leads to brain swelling and headache, restlessness, nausea, muscle cramps and fatigue [ 5 , 6 ]; the release of cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor-alpha [ 7 , 8 , 9 ]; the accumulation of metabolites and toxins in the muscle [ 10 ]).…”

Section: Introductionmentioning

confidence: 99%

Use of Proton Pump Inhibitors Is Not Associated with Post-Dialysis Fatigue and Time of Recovery after Dialysis in Patients on Maintenance Hemodialysis

Bossola,

Mariani,

Monteburini

et al. 2024

JCM

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Objectives: To define if the use of proton pump inhibitors (PPI) is associated with PDF prevalence and characteristics and with time of recovery after dialysis in patients on maintenance hemodialysis. Methods: Patients were defined as experiencing PDF if they spontaneously offered this complaint when asked the open-ended question: “Do you feel fatigued after dialysis?”. Time of recovery after dialysis (TIRD) was also assessed for each patient. Each patient was invited to rate the intensity, duration and frequency of PDF from 1 to 5. We defined if patients used PPI (no PPI use or PPI use), the type of used PPI, the dose of used PPI, and the duration of the use of PPI (<1 year or ≥1 year). Results: A total of 346 patients were studied: 259 used PPI (55 used omeprazole, 63 esomeprazole, 54 pantoprazole, 87 lansoprazole, and 7 rabeprazole) and 87 did not. Two hundred and thirty-two patients declared PDF and 114 did not. The median [min–max] TIRD was 210 min [0–1440]. The prevalence of PDF in PPI users and PPI non-users was 67% and 68%, respectively (p = 0.878). The median [min–max] TIRD did not differ significantly between PPI users and PPI non-users (180 [0–1440] and 240 [0–1440], respectively; p = 0.871). Median PDF intensity, duration, frequency, and severity did not differ significantly between PPI use and no use. The prevalence of PDF was similar among the different types of PPI use and did not differ with respect to PPI non-users. Duration of PPI exposure was <1 year in 40 patients and ≥1 year in 219 patients. The prevalence of PDF did not differ between the two exposures. The correlation matrix between PPI equivalent dose, PPI treatment duration and PDF frequency, PDF characteristics, and TIRD showed whether there was statistical significance. Conclusions: The use of PPI is not associated with PDF and time of recovery after dialysis in patients on maintenance hemodialysis.

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“…In comparison with IDF, a persistent condition, PDF as an emerging eld in recent years often be described as "feeling worn out, drained, or exhausted or tired and needing rest or sleep after the dialysis session", with the recovery time after dialysis may last from less than 2 hours to more than 12 hours [6]. According to a meta-analysis of PDF, the overall prevalence of PDF is 60.0%, ranging from 42.9-80.8% [7]. Due to the lack of a pooled incidence of IDF, the prevalence of IDF and PDF in MHD patients cannot be directly compared.…”

Section: Introductionmentioning

confidence: 99%

“…Unlike IDF, till now, the association between PDF and social-psychological factors, such as depression, anxiety, and resilience, has been reported as very limited. In addition, both types have common in uencing factors, such as age, ultra ltration volume, sleep quality ect [7], but the direct comparison of its between IDF and PDF has not been well characterized.…”

Section: Introductionmentioning

confidence: 99%

Comparison of the prevalence and associated factors of interdialytic fatigue and post-dialysis fatigue among maintenance hemodialysis patients: A cross-sectional study

Dou,

Mei,

Yang

et al. 2023

Preprint

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Objective Interdialytic Fatigue (IDF) and post-dialysis fatigue (PDF) were the most common complication among maintenance hemodialysis (MHD) patients. However, the differences between IDF and PDF in MHD patients have been reported little and their concepts were easy to be confused by some studies. The purpose of this study was to compare the prevalence of fatigue and investigate the differences in the contributing factors between IDF and PDF in patients receiving MHD therapy. Methods In this cross-sectional study, 217 MHD patients, from a comprehensive hospital in China, were recruited and collected from January 2022 to June 2022. The Function assessment of Chronic Illness Therapy-Fatigue (FACIT-F) was adopted to measure IDF and PDF. Psychosocial factors included resilience, quality of sleep, and social support which were estimated by the 10-item Connor-Davidson Resilience Scale(CD-RISC), Pittsburgh Sleep Quality Index(PSQI), and Social Support Rate Scale(SSRS), respectively. Multiple logistic regression analyses were performed to identify influencing factors of IDF and PDF in patients on MHD therapy. Results The prevalence of IDF and PDF was 29.0% and 61.8%, respectively, and With 96.8% of MHD patients with IDF suffered from PDF. Multiple logistic regression analysis revealed that the independent factors of fatigue were age(p < .001), resilience(p < .001), and sleep quality(p = .001) and age(p = .007), resilience(p < .001), and intradialytic hypotension (IDH) (p < .001) were contributing factors of PDF. Conclusion The prevalence of PDF was significantly higher than IDF among MHD patients. Age and resilience were common independent factors of fatigue and PDF.

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Prevalence and Risk Factors of Postdialysis Fatigue in Patients Under Maintenance Hemodialysis: A Systematic Review and Meta-Analysis

Cited by 6 publications

References 19 publications

Short-Physical Performance Batter：Complete Mediator of Cognitive Depressive Symptoms and Diabetes Mellitus in Hemodialysis Patients

Short-Physical Performance Batter：Complete Mediator of Cognitive Depressive Symptoms and Diabetes Mellitus in Hemodialysis Patients

Use of Proton Pump Inhibitors Is Not Associated with Post-Dialysis Fatigue and Time of Recovery after Dialysis in Patients on Maintenance Hemodialysis

Comparison of the prevalence and associated factors of interdialytic fatigue and post-dialysis fatigue among maintenance hemodialysis patients: A cross-sectional study

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