Prevalence and risk factors of Echinococcus granulosus infection in dogs in Moroto and Bukedea districts in Uganda

Oba, Peter; Ejobi, Francis; Omadang, Leonard; Chamai, Martin; Okwi, Andrew Livex; Othieno, Emmanuel; Inangolet, Francis Olaki; Ocaido, Michael

doi:10.1007/s11250-015-0943-z

Cited by 19 publications

(31 citation statements)

References 17 publications

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“…Dog-human-livestock interactions were intensive among these communities. Dogs were often kept for security reasons [44][45][46]. It has been consistently seen in various studies through the years and confirmed by our study that this disease in seen in young population who are in their active years.…”

Section: Discussionsupporting

confidence: 88%

Role of Serology and Histopathology in Diagnostic of Human Cystic Echinococcosis

Albadaw¹

2018

JIDTM

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Introduction: Hydatid disease is an important emerging neglected disease worldwide, with significant geographic variation in seroprevalance. The disease is commonly diagnosed on basis of clinical suspicion, imaging and serology. This study was conducted to evaluate our experience with serology in diagnosing hydatid disease in terms of identifying the numbers of patients testing positive for antibodies against Echinococcus, and to study their clinical profile. This study included all patients who tested for anti-Echinococcus IgG antibodies by ELISA in the years 2011-2013. The clinical characteristics of seropositive patients were contrasted with seronegative patients, and the test results were correlated with radiological findings and, where performed, with histopathological studies. Analysis was performed on SPSS. Out of 31 patients evaluated by serology for Echinococcosis during the study period, 7 (22.58%) were seropositive. Liver was the most frequent site involved (24 patients; 77.77%). Second organ the lung 5(16.13%) bone 1(3.23%) and the optic 1(3.22%).Of the 29 patients who also underwent biopsy, all the seven patients with positive biopsy were seropositive, suggesting 100% sensitivity. The specificity was 83.33%, but this might be a lower estimate due to potentially high rate of false-negative biopsies, as all the seropositive patients also had imaging features suggestive of disease. The positive and negative predictive values were 77.77% and 90.90%, respectively. ELISA for detection of anti Echinococcus antibodies is a simple serological test that helps in correlation with imaging finding in the diagnosis and subsequent management of hydatid disease. Albadawi AAM, et al. Role of Serology and Histopathology in Diagnostic of Human Cystic Echinococcosis. J Inf Dis Trav Med 2018, 2(3): 000116. Copyright© Albadawi AAM, et al.2Material and Methods: A cross sectional study was done on biological material (obtained from haptic and lung hydatid cysts). The viability criteria used were ovoid form invaginated scolices and intact calcareous corpuscles the presences of vibrating movements; and the absence of "vital" staining. The cysts were grouped according to diameter cysts from small cysts to very large size cysts. Descriptive statics for the collection of the prevalence of fertility; analytical statistics for comparison of groups, and multivariate analysis for examination of the association between cyst fertility and clinical variables. Is using to carry out by SPSS programme.Result: Out of 31 patients evaluated by serology and histopathology for Echinococcosis during the study period, 7(22.58%) were seropositive. Liver and lung was the most frequent site involved all the seven patients with positive biopsy were seropositive, suggesting 100% sensitivity. The specificity was 83.33%, but this might be a lower estimate due to potentially high rate of false-negative biopsies, as all the seropositive patients also had imaging features suggestive of disease. The positive and negative predictive values were 77.77% and 9...

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Section: Discussionsupporting

confidence: 88%

Role of Serology and Histopathology in Diagnostic of Human Cystic Echinococcosis

Albadaw¹

2018

JIDTM

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“…On postmortem, the prevalence of 66.3% had earlier on been reported among dogs in Karamoja [11]. E. granulosus infection risk factors for dogs in Karamoja have been reported to be as free access to slaughter places including home slaughter, high livestock populations and lack of knowledge about epidemiology of CE [20].…”

Section: Discussionmentioning

confidence: 97%

“…Dog-human-livestock interactions were intensive among these communities. Dogs were often kept for security reasons [15,19,20].…”

Section: Discussionmentioning

confidence: 99%

“…This means that dog ownership was a risk factor for CE in Karamoja which could not be elucidated by the statistical analysis performed. A recent study [20] reported a prevalence of E. granulosus of 14.4% using copro-polymerase chain reaction of among dogs in Moroto district, Karamoja region. On postmortem, the prevalence of 66.3% had earlier on been reported among dogs in Karamoja [11].…”

Section: Discussionmentioning

confidence: 99%

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Risk factors associated with cystic echinococcosis in humans in selected pastoral and agro-pastoral areas of Uganda

Othieno¹,

Okwi²,

Mupere³

et al. 2017

IJOH

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Aim: It was to determine the risk factors responsible of occurrence of cystic echinococcosis (CE) of humans in the pastoral and agro-pastoral (PAP) in Uganda. Materials and Methods:A cross-sectional study was conducted in districts: Moroto, Napak, Nakapiripirit and Amudat in Karamoja region; in agro-pastoral communities of Teso region, in the districts of Kumi and Bukedea; Nakasongola district in Central region and in Kasese district in the Western region. People were subjected to voluntary ultrasound screening for CE. Those found positive to CE on ultrasound screening were interviewed using a special designed form to find out the probable predisposing factors for acquisition of CE infection. Predisposing factors considered were location, age, sex, dog ownership, occupation, water source, and religion. Univariate and multivariate logistic regression analysis was performed to identify key risk factors. Results:In Karamoja region, being female, age beyond 40 years and open spring water sources were the risk factors. While for Nakasongola age beyond 40 years was a risk factor. In Kasese dog ownership, age >60 years and being a Muslim were risk factors. In Teso region dog ownership and age >60 years were the risk factors. Conclusion:Being a pastoralist, a female, increasing age beyond 40 years, open spring water sources, dog ownership and being a Muslim were the risk factors for CE in PAP areas in Uganda.

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“…Es necesario entonces enfocarse también en los factores de riesgo factibles de modificar, dentro de los cuales están algunas prác-ticas como alimentar a los perros con vísceras de animales 11,30,31 o la correcta disposición de las heces de los perros 11 . En lo relacionado con el conocimiento de la enfermedad, se ha visto que el hecho que la población conozca las vías de transmisión desde el perro y el modo de infección de éste, es un factor protector 31 .…”

Section: Discussionunclassified

Análisis de la hidatidosis humana en la Región de Coquimbo entre los años 2008 y 2012

et al. 2017

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Prevalence and risk factors of Echinococcus granulosus infection in dogs in Moroto and Bukedea districts in Uganda

Cited by 19 publications

References 17 publications

Role of Serology and Histopathology in Diagnostic of Human Cystic Echinococcosis

Role of Serology and Histopathology in Diagnostic of Human Cystic Echinococcosis

Risk factors associated with cystic echinococcosis in humans in selected pastoral and agro-pastoral areas of Uganda

Análisis de la hidatidosis humana en la Región de Coquimbo entre los años 2008 y 2012

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