Prevalence and risk factors of RLS in an elderly population

Rothdach, Andreas; Trenkwalder, Claudia; Haberstock, J.; Keil, U; Berger, Klaus

doi:10.1212/wnl.54.5.1064

Cited by 612 publications

(445 citation statements)

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“…Regarding the male population, the prevalence of RLS was 5.76%. This rate is similar to the one shown by Rothdach 4 and Ulfberg 23 . The latter author conducted a study with an exclusively male population and the prevalence of RLS was 5.8%.…”

Section: Resultssupporting

confidence: 90%

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086 Restless Legs Syndrome – A Study of Prevalence Among Medical School Faculty Members

Haggstrãm¹,

Bigolin²,

Assoni³

et al. 2009

Sleep Medicine

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-The aim of this study was to assess the prevalence of idiopathic restless legs syndrome (RLS) and its correlations in a sample of Medical School faculty members. A transversal study was conducted at a Medical School in the south of Brazil included 78 faculty members. The subjects answered to a structured questionnaire specific to RLS diagnosis and the Epworth and the Stanford scales to measure daytime sleepiness. Severity of the disease was also evaluated. The variables were analyzed to statistical significance. RLS was diagnosed in 10.25% of the subjects evaluated and most were women (62.5%). The prevalence of daytime sleepiness was significantly greater among the subjects suffering from RLS (p=0.04). RLS subjects were significantly younger than the group without the syndrome (p=0.02). RLS had a considerable prevalence in the sample studied. Daytime sleepiness and young age showed an important correlation to this syndrome, as other potential factors were not confirmed.KEy WoRDS: restless leg syndrome, prevalence, idiopathic, daytime sleepness. síndrome das pernas inquietas: estudo de prevalência entre professores do curso de medicina Resumo -o objetivo deste estudo foi analisar a prevalência da síndrome das pernas inquietas (SPI) e suas implicações clínicas em uma amostra envolvendo docentes de um curso de Medicina. Foi realizado um estudo transversal que envolveu 78 docentes do curso de Medicina de uma Universidade do Sul do Brasil. os indivíduos avaliados responderam um questionário com perguntas epidemiológicas e de diagnóstico para SPI, assim como escalas de sonolência de Epworth e Stanford. os portadores de SPI responderam questionário de gravidade. As variáveis foram analisadas quanto à significância estatística. obtivemos uma prevalência de indivíduos portadores de SPI de 10,25%, sendo 62,5% destes do sexo feminino. A existência de sonolência diurna excessiva foi significativamente maior em pacientes portadores da síndrome (p=0,04). os pacientes portadores de SPI possuíam idade significativamente inferior ao grupo não sindrômico (p=0,02). A SPI mostrou-se bastante prevalente em nossa amostra. A prevalência de sonolência diurna e menos idade mostrou importante relação com esta síndrome, enquanto outros fatores possivelmente relacionados não foram confirmados.PALAvRAS-ChAvE: síndrome das pernas inquietas, prevalência, idiopática, sonolência diurna.

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Section: Resultssupporting

confidence: 90%

“…Fifty years after its complete description, definition and major criteria to its diagnosis was published by a group entitled International Restless Legs Syndrome Study Group (IRLSSG) 2 . Despite the fact of being long known and of high prevalence in the population, knowledge about RLS still remains very limited among health care professionals 3,4 .…”

mentioning

confidence: 99%

086 Restless Legs Syndrome – A Study of Prevalence Among Medical School Faculty Members

Haggstrãm¹,

Bigolin²,

Assoni³

et al. 2009

Sleep Medicine

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“…Previous population-based studies found an increasing prevalence of RLS with age 11 , and controversial results about gender 11,13 . Unlike primary RLS, it seems that age and gender are not important factors for the development of RLS in CRF subjects.…”

Section: Discussionmentioning

confidence: 92%

“…Data in population-based studies 11,13 about correlation between RLS and smoking was controversial. Many of our patients might have felt ashamed or frightened when asked about smoking habits, so we cannot attest the reliability of our results.…”

Section: Discussionmentioning

confidence: 99%

Restless legs syndrome in patients on chronic hemodialysis in a Brazilian city: frequency, biochemical findings and comorbidities

Filho

Gorini

Purysko

et al. 2003

Arq. Neuro-Psiquiatr.

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-Objective: To evaluate the frequency of restless legs syndrome (RLS) in patients with chronic renal failure (CRF) in Petrópolis, Brazil, and investigate associations between the syndrome and: demographic characteristics, biochemical variables and comorbidities. Method: A cross-sectional study in which we interviewed 176 patients on dialytic therapy based on criteria elaborated by the International Restless Legs Syndrome Study Group, and compared data of patients with and without RLS. Results: The frequency was 14.8 %. There were no significant differences between the two groups in demographic and biochemical variables investigated (iron, creatinine, intact parathyroid hormone, hemoglobin, calcium, phosphate). We found no association between RLS and the most common comorbidities, except for chronic glomerulonephritis (CGN) (OR = 3.84, p < 0.01). Conclusion: In the studied population RLS is a common disorder, and is not associated with the investigated biochemical abnormalities. A higher frequency of RLS in subjects with CGN is a finding that needs further investigation.KEY WORDS: restless legs syndrome, chronic renal failure, chronic glomerulonephritis.Síndrome das pernas inquietas em pacientes em programa de hemodiálise em P índrome das pernas inquietas em pacientes em programa de hemodiálise em P índrome das pernas inquietas em pacientes em programa de hemodiálise em P índrome das pernas inquietas em pacientes em programa de hemodiálise em P índrome das pernas inquietas em pacientes em programa de hemodiálise em Petrópolis, RJ: frequência, etrópolis, RJ: frequência, etrópolis, RJ: frequência, etrópolis, RJ: frequência, etrópolis, RJ: frequência, aspectos laboratoriais e comorbidades. aspectos laboratoriais e comorbidades. aspectos laboratoriais e comorbidades. aspectos laboratoriais e comorbidades. aspectos laboratoriais e comorbidades. RESUMO -Objetivo: Determinar a frequência de síndrome das pernas inquietas (SPI) em pacientes com insuficiência renal crônica (IRC) em Petrópolis, Brasil, e investigar associação entre a síndrome e: dados demográficos, achados bioquímicos e comorbidades. Método: Estudo transversal no qual entrevistamos 176 pacientes em terapia dialítica a partir de critérios definidos pelo International Restless Legs Syndrome Study Group, e comparamos dados de pacientes com e sem SPI. Resultado: A frequência foi 14,8 %. Não houve diferença significativa entre os 2 grupos nas variáveis demográficas e bioquímicas (ferro, cretinina, paratormônio, hemoglobina, cálcio, fósforo) investigadas. Não houve associação entre SPI e as principais comorbidades, exceto glomerulonefrite crônica (GNC) (OR = 3,84, p < 0,01). Conclusão: SPI é condição comum na população estudada, e não é associada com as alterações bioquímicas investigadas. O achado de maior frequência de SPI em pacientes com GNC merece investigações mais detalhadas. The frequency of restless legs syndrome (RLS) is higher in patients with end-stage renal disease than in the general population, and previous studies have reported it to vary...

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“…14 Similarly, hormone replacement therapy use was found to be significantly more frequent in women with RLS in one study 15 but not in two others. 16,17 In a randomized study of hormonal therapy for postmenopausal women, RLS complaints were significantly less for those on estrogen + progesterone compared to baseline, but not different for those on estrogen or progesterone alone. 18 Perhaps there is a genetically predisposed subset of women for whom estrogen is an exacerbating factor, but this relationship may be diminished when all women are considered.…”

Section: Disclosure Statementmentioning

confidence: 99%

Restless Legs Syndrome: What Have We Learned from Prevalence Studies and How Will Incidence Studies Further Clinical Knowledge?

Picchietti

Picchietti²

2012

Journal of Clinical Sleep Medicine

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C o m m e n t a R YR estless legs syndrome (RLS), also known as Willis-Ekbom disease, is now generally appreciated in the medical literature as common and complex. Over 50 prevalence studies, most published since 2005, have been crucial in defi ning many important clinical aspects. In this issue of JCSM is one of the fi rst general population-based incidence studies of RLS. 1 How are incidence studies different, and how might they further clinical knowledge?First, let us review the "Top Five" agreed upon fi ndings from prevalence studies of RLS. 2 Number 5: Prevalence in females is about twice as high as in males, beginning in the late teens or 20s. Number 4: Association with other conditions. Individuals with RLS are at least twice as likely to have scores indicating a depressive or anxiety disorder. This has major clinical implications in that common treatments for these disorders can worsen RLS, 3 and because ongoing sleep disturbance is a known risk factor for the onset and persistence of depressive disorders, as well as for suicidality. Interestingly, emerging evidence indicates at least twice the risk of cardiovascular disease in RLS. Less agreement has been found regarding increased comorbidity with numerous other disorders, including hypertension, diabetes, and obesity. Number 3: Quality of life (QOL) impairments are signifi cant in moderate-to-severe RLS, comparable to diabetes and congestive heart failure. 4 These include lower physical and mental health scores, with disturbed sleep very common by both subjective and objective measures. Number 2: There is a wide spectrum of frequency/severity. Of those meeting the four essential IRLSSG criteria, application of frequency at least 1x/week represents 60% of the RLS population; at least 2x/week is about 50%; and daily is about 20%. Clinically signifi cant RLS-RLS associated with higher morbidity and where treatment should be considered-can be defi ned by frequency/severity measures. Occurrence at least 1-2x/week, typically with moderate to severe distress, is the most common defi nition in the epidemiologic studies that show impairment.Number 1: Consideration of differential diagnosis is very important. Exclusion of "mimics" of RLS, such as leg cramps, positional discomfort, arthritis, and leg edema, leads to specifi city of diagnosis, 5 and prevalence rates of 1.9% to 4.6% for moderate-to-severe RLS in European and North American studies. 2 Without differential diagnosis prevalence estimates are about 1.25 to 2 times higher. Importantly, the 2012 revision of the International RLS Study Group (IRLSSG) diagnostic criteria will include differential diagnosis as a 5 th essential criterion, as is also planned for the International Classifi cation of Sleep Disorders (ICSD-3) and the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) in 2013.Incidence rate is an estimate of the number of new cases in a population over a given time period, as compared to prevalence, which estimates the total number of cases in a population at a given time. Incidence pr...

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Prevalence and risk factors of RLS in an elderly population

Abstract: RLS is a frequent syndrome in the elderly with considerable impact on self-perceived mental health, affecting women about twice as often as men.

Cited by 612 publications

References 15 publications

086 Restless Legs Syndrome – A Study of Prevalence Among Medical School Faculty Members

086 Restless Legs Syndrome – A Study of Prevalence Among Medical School Faculty Members

Restless legs syndrome in patients on chronic hemodialysis in a Brazilian city: frequency, biochemical findings and comorbidities

Restless Legs Syndrome: What Have We Learned from Prevalence Studies and How Will Incidence Studies Further Clinical Knowledge?

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