Prevalence and risk factors of aortic stenosis and aortic sclerosis: a 21-year follow-up of middle-aged men

Kontogeorgos, Silvana; Thunström, Erik; Basic, Carmen; Hansson, Per‐Olof; Zhang, You; Ergatoudes, Constantinos; Morales, David; Mandalenakis, Zacharias; Rosengren, Annika; Caidahl, Kenneth; Fu, Michael

doi:10.1080/14017431.2019.1685126

Cited by 14 publications

(19 citation statements)

References 47 publications

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“…Changes in HRV indices have been identified in several other conditions such as diabetes, hypertension, dyslipidemia or obesity [ 7 , 46 , 47 ]. Given that these conditions are recognized as some of the concomitant risk factors for the manifestation and progression of valvular calcification [ 46 , 48 , 49 ], further research enrolling a larger number of cases is required to elucidate how such factors could be involved in the differences and attenuated response to active standing reported here.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Autonomic Response to Active Standing in Calcific Aortic Valve Stenosis

Torres-Arellano

Ávila-Vanzzini

Springall

et al. 2021

JCM

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Aortic stenosis is a progressive heart valve disorder characterized by calcification of the leaflets. Heart rate variability (HRV) analysis has been proposed for assessing the heart response to autonomic activity, which is documented to be altered in different cardiac diseases. The objective of the study was to evaluate changes of HRV in patients with aortic stenosis by an active standing challenge. Twenty-two volunteers without alterations in the aortic valve (NAV) and twenty-five patients diagnosed with moderate and severe calcific aortic valve stenosis (AVS) participated in this cross-sectional study. Ten minute electrocardiograms were performed in a supine position and in active standing positions afterwards, to obtain temporal, spectral, and scaling HRV indices: mean value of all NN intervals (meanNN), low-frequency (LF) and high-frequency (HF) bands spectral power, and the short-term scaling indices (α1 and αsign1). The AVS group showed higher values of LF, LF/HF and αsign1 compared with the NAV group at supine position. These patients also expressed smaller changes in meanNN, LF, HF, LF/HF, α1, and αsign1 between positions. In conclusion, we confirmed from short-term recordings that patients with moderate and severe calcific AVS have a decreased cardiac parasympathetic supine response and that the dynamic of heart rate fluctuations is modified compared to NAV subjects, but we also evidenced that they manifest reduced autonomic adjustments caused by the active standing challenge.

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Section: Discussionmentioning

confidence: 99%

Cardiac Autonomic Response to Active Standing in Calcific Aortic Valve Stenosis

Torres-Arellano

Ávila-Vanzzini

Springall

et al. 2021

JCM

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“…All 798 men who were examined in 1993 were invited to a re-examination in 2003 all at age 60 years, where 655 out of 773 who were still alive (84.7%) were re-examined, and in 2014, at the age of 71 years 536 out of 688 men still alive (77.9%) were re-examined. The follow-up procedure is previously described in detail 12 – 14 .…”

Section: Methodsmentioning

confidence: 99%

Incremental changes in QRS duration as predictor for cardiovascular disease: a 21-year follow-up of a randomly selected general population

Chen

Hansson

Thunström

et al. 2021

Sci Rep

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The QRS complex has been shown to be a prognostic marker in coronary artery disease. However, the changes in QRS duration over time, and its predictive value for cardiovascular disease in the general population is poorly studied. So we aimed to explore if increased QRS duration from the age of 50–60 is associated with increased risk of major cardiovascular events during a further follow-up to age 71. A random population sample of 798 men born in 1943 were examined in 1993 at 50 years of age, and re-examined in 2003 at age 60 and 2014 at age 71. Participants who developed cardiovascular disease before the re-examination in 2003 (n = 86) or missing value of QRS duration in 2003 (n = 127) were excluded. ΔQRS was defined as increase in QRS duration from age 50 to 60. Participants were divided into three groups: group 1: ΔQRS < 4 ms, group 2: 4 ms ≤ ΔQRS < 8 ms, group 3: ΔQRS ≥ 8 ms. Endpoints were major cardiovascular events. And we found compared with men in group 1 (ΔQRS < 4 ms), men with ΔQRS ≥ 8 ms had a 56% increased risk of MACE during follow-up to 71 years of age after adjusted for BMI, systolic blood pressure, smoking, hyperlipidemia, diabetes and heart rate in a multivariable Cox regression analysis (HR 1.56, 95% CI:1.07–2.27, P = 0.022). In conclusion, in this longitudinal follow-up over a decade QRS duration increased in almost two out of three men between age 50 and 60 and the increased QRS duration in middle age is an independent predictor of major cardiovascular events.

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“…Sci. Lett., 2021, 8(3): 60-66 million people are predicted to decease annually because of cardiovascular disease [5], and the prevalence of HF to rise by 25% [6]. HF is often referred to as Congestive Heart Failure (CHF), i.e.…”

Section: Cardiovascularmentioning

confidence: 99%