Prevalence and Risk Factors for HIV Infection Among Heterosexual Men Recruited from Socializing Venues in Rural KwaZulu-Natal, South Africa

Ntombela, Nonzwakazi P; Kharsany, Ayesha B. M.; Soogun, Adenike O.; Yende‐Zuma, Nonhlanhla; Kohler, Hans‐Peter; McKinnon, Lyle R.

doi:10.1007/s10461-021-03182-3

Cited by 7 publications

(5 citation statements)

References 30 publications

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“…Men in our study mentioned taverns, shebeens, and places where men play games as safe spaces in which to engage about health issues, offer screening or testing services, and provide treatment support. While these and sporting events have been previously suggested and used to engage men, ( Grammatico et al, 2021 ; Ntombela et al., 2021 ) other gender and culturally sensitive spaces should also be considered. In Xhosa culture, kraals may be particular amenable to engaging in sensitive health conversations; a kraal is a masculine space where adult Xhosa men meet and discuss matters of importance to the community, provide advice to younger men and perform traditional ceremonies ( Bank, 2015 ; Right to Care, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Qualitative Identification of Intervention Preferences to Support Men’s Engagement and Retention in TB Care in South Africa

et al. 2022

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Globally and in South African specifically, men account for 56% and 62% of all tuberculosis (TB) cases, respectively. Men are at increased risk of not accessing TB testing or treatment, and having poor treatment outcomes. Unfortunately, no interventions exist to address these issues. Toward the development of targeted, patient-centered TB care and support interventions, we used semistructured interviews to explored men’s social network composition, TB testing behaviors, disclosure and treatment support, clinical experiences, and TB’s influence on daily living. Data were analyzed using a thematic approach guided by the Network Individual Resource Model to identify mental and tangible resources influential and preferred during engagement in TB treatment. Men emphasized the desire for peer-to-peer support to navigate TB-related stigma and unhealthy masculinity norms. Men advocated for awareness events to educate communities about their challenges with TB. Men strongly suggested that interventions be delivered in familiar locations where men congregate. Since 2022, no TB treatment support interventions have included the preferred components or delivery modes described by men in our study. To improve men’s TB-related health outcomes, the global TB community must identify and address men’s unique challenges when designing interventions.

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Section: Discussionmentioning

confidence: 99%

Qualitative Identification of Intervention Preferences to Support Men’s Engagement and Retention in TB Care in South Africa

et al. 2022

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“…These results affirm several studies that have found a positive correlation between school attendance and increased educational attainment and lower HIV incidence in South Africa. [8][9][10][11][12][13]17,20 Identifying the precise causal effect remains challenging, 14 with some studies suggesting that adolescent acquire sexual health guidance, regardless of dedicated curricula covering the subject, 16,21 with attending school also potentially disrupting sexual networks. 22 All analysis was weighted.…”

Section: Discussionmentioning

confidence: 99%

Role of Schooling and Comprehensive Sexuality Education in Reducing HIV and Pregnancy Among Adolescents in South Africa

George

Beckett

Reddy

et al. 2022

JAIDS Journal of Acquired Immune Deficiency Syndromes

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“…To estimate the episodes of ACLF, acute kidney injury (AKI), HE, and infection, a generalized estimating equation (GEE) with logistic regression for the dichotomous outcome variables was built, accounting for the within-subject correlation across the 6-month period, by means of exchangeable correlation structure, as previously mentioned. 27,28 The GEE was performed to assess the association of serum levels of calcitriol, CD206, Mincle, and other immune markers with the episodes after adjustment for covariates, such as age, sex, Child-Pugh score (being separated into class A and B+C dichotomously according to the nearly equivalent numbers of participants), ALBI grade (separated into grade 1 and 2 + 3 dichotomously according to the nearly equivalent numbers of participants), and MELD score. The cutoff values of calcitriol, CD206, and Mincle were derived from the individual tertiles or quartiles of the study participants, regardless of whether they developed ACLF in the 6-month follow-up through the GEE analysis.…”

Section: Methodsmentioning

confidence: 99%

Low lymphocyte-to-monocyte ratio, calcitriol level, and CD206 level predict the development of acute-on-chronic liver failure in patients cirrhosis with acute decompensation

Kuo

Hou

Chu

et al. 2023

Journal of the Chinese Medical Association

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Background: Cirrhosis-related acute-on-chronic liver failure (ACLF) is associated with high morbidity and mortality rates. Prognostic models of ACLF have been developed; however, few studies have focused on the occurrence of ACLF. This study aimed to identify the factors that predict the development of ACLF, hepatic encephalopathy (HE), and infection in patients with cirrhosis. Methods: Patients with cirrhosis were enrolled, and the serum levels of calcitriol, Cluster of Differentiation 26 (CD206), and macrophage-inducible lectin receptor (Mincle) were measured, and lymphocyte-to-monocyte ratio (LMR) and neutrophil-to-lymphocyte ratio were calculated; all the patients were tracked for 6 months. A generalized estimating equation (GEE) was used to assess the factors associated with ACLF development, HE, and infection. The aforementioned model was derived based on immunological markers, and receiver operating characteristic analysis with area under the curve (AUC) was adopted to evaluate accuracy. Results: After screening 325 patients with cirrhosis, 65 patients were eligible. In the GEE model, low levels of calcitriol (odds ratio [OR] = 3.259; 95% confidence interval [CI] = 1.118-8.929) and CD206 (OR = 2.666; 95% CI = 1.082-6.567) were associated with the development of ACLF, and the LMR was a protective factor (OR = 0.356; 95% CI = 0.147-0.861). Low calcitriol levels were a risk factor for HE (OR = 3.827) and infection (OR = 2.489). LMR was found to be a protective factor against HE (OR = 0.388). An immunological model for the discrimination of ACLF development within 6 months was proposed, with an AUC of 0.734 (95% CI = 0.598-0.869). Conclusion: Single and combined immunological markers, including low LMR and low levels of calcitriol and CD206, were promising for early prediction of the development of ACLF, HE, and infection in patients with cirrhosis.

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Prevalence and Risk Factors for HIV Infection Among Heterosexual Men Recruited from Socializing Venues in Rural KwaZulu-Natal, South Africa

Cited by 7 publications

References 30 publications

Qualitative Identification of Intervention Preferences to Support Men’s Engagement and Retention in TB Care in South Africa

Qualitative Identification of Intervention Preferences to Support Men’s Engagement and Retention in TB Care in South Africa

Role of Schooling and Comprehensive Sexuality Education in Reducing HIV and Pregnancy Among Adolescents in South Africa

Low lymphocyte-to-monocyte ratio, calcitriol level, and CD206 level predict the development of acute-on-chronic liver failure in patients cirrhosis with acute decompensation

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